2022
DOI: 10.1016/j.ebiom.2022.103992
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Inflammation and resolution signaling in cardiac repair and heart failure

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Cited by 127 publications
(69 citation statements)
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“…Overwhelming infiltration of innate immune cells has been shown to promote adverse remodeling and cardiac rupture 64 . The successful resolution of inflammation appears as a critical event in the repair of tissue damage, but little is known about the primary mediators of resolution in the infarcted cardiac tissue [65][66][67] . Neutrophils massively infiltrate the heart soon after MI, where they can promote both tissue repair and damage 14,49 .…”
Section: Discussionmentioning
confidence: 99%
“…Overwhelming infiltration of innate immune cells has been shown to promote adverse remodeling and cardiac rupture 64 . The successful resolution of inflammation appears as a critical event in the repair of tissue damage, but little is known about the primary mediators of resolution in the infarcted cardiac tissue [65][66][67] . Neutrophils massively infiltrate the heart soon after MI, where they can promote both tissue repair and damage 14,49 .…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, studies have found that immune in ammatory response can promote ventricular remodeling and play a key role in the development of CHF 18 . The causal relationship between in ammation and HF risk is still being explored, but it is clear that elevated in ammatory markers are closely associated with poor prognosis in CHF [19][20] . As innate immune cells neutrophils plays a key role in the in ammatory response, when it is not subject to adjustment promote tissue damage and the loss of balance in the body, accelerate the organ dysfunction, lymphocytes to the environmental conditions and organs of steady state is unusually rapid response, the interaction between the network cross is a key determinant of immune response 21 .…”
Section: Discussionmentioning
confidence: 99%
“…HF can occur as a result of valvular heart disease, hypertension, ischemic heart disease, and myocardial infarction (MI) ( 101 ). A great deal of evidence suggests that the onset and progression of HF is intimately associated with inflammation, no matter the underlying etiology ( 102 , 103 ). The induction and activation of chemokines is one of the features of the inflammatory response in the failing heart ( 104 ).…”
Section: Ccl2-ccr2 Axis and Cardiovascular Diseasementioning
confidence: 99%