Inflammation and retinal degenerative diseases

Singh, NikhleshK; Kaur, Geetika

doi:10.4103/1673-5374.350192

Cited by 30 publications

(4 citation statements)

References 78 publications

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“…Retinal inflammatory response is implicated in the pathogenesis of glaucoma and in glaucomatous conditions, and Müller cells undergo reactivation (gliosis). , Under pathological conditions, activated retinal glial cells fail to play their neuroprotective roles and promote widespread inflammatory factors, including tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) and interleukins . TNF-α is a major inflammatory factor and release from activated Müller cells and microglia glia.…”

Section: Manageable Diseases Through Eyesmentioning

confidence: 99%

“…126 Multiple changes occur in Muller cells under pathological conditions, such as the release of various stress signals, disruption of the retinal architecture, changes in the excitatory synaptic transmission, and changes in the synthesis and release of both neuroprotective and detrimental factors. 127,128 Risk factors of RGC damage include glutamate excitotoxicity, 129 oxidative stress, neuroinflammation, altered mitochondrial dynamics, and other mechanisms that can lead to changes in retinal homeostasis in the microenvironment.…”

Section: Glaucomamentioning

confidence: 99%

“…118,150 their neuroprotective roles and promote widespread inflammatory factors, including tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) and interleukins. 127 TNF-α is a major inflammatory factor and release from activated Muller cells and microglia glia. These factors aggravate cytotoxic reaction and RGC degeneration.…”

Section: Inflammatory Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Seo,

Chung,

Kwon

et al. 2023

Chem. Rev.

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The eye contains a complex network of physiological information and biomarkers for monitoring disease and managing health, and ocular devices can be used to effectively perform point-of-care diagnosis and disease management. This comprehensive review describes the target biomarkers and various diseases, including ophthalmic diseases, metabolic diseases, and neurological diseases, based on the physiological and anatomical background of the eye. This review also includes the recent technologies utilized in eyewearable medical devices and the latest trends in wearable ophthalmic devices, specifically smart contact lenses for the purpose of disease management. After introducing other ocular devices such as the retinal prosthesis, we further discuss the current challenges and potential possibilities of smart contact lenses.

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Section: Manageable Diseases Through Eyesmentioning

confidence: 99%

Section: Glaucomamentioning

confidence: 99%

Section: Inflammatory Factorsmentioning

confidence: 99%

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Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Seo,

Chung,

Kwon

et al. 2023

Chem. Rev.

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“…Generally, IEDs are classified based on both the mechanism of injury and the affected location. Based on injury mechanism, IEDs are categorized as: (a) inflammation-related diseases, (b) degenerative conditions with remarkable inflammatory components, (c) neuropathy, and (d) tumors ( 12 , 13 ). Typical examples of ocular degenerations are Dry Eye Syndrome (DES), glaucoma, Diabetic Retinopathy (DR), and Age-related Macular Degeneration (AMD).…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Habibi

Zarei-Behjani²,

Falamarzi³

et al. 2023

Front. Immunol.

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Extracellular vesicles include exosomes, microvesicles, and apoptotic bodies. Their cargos contain a diverse variety of lipids, proteins, and nucleic acids that are involved in both normal physiology and pathology of the ocular system. Thus, studying extracellular vesicles may lead to a more comprehensive understanding of the pathogenesis, diagnosis, and even potential treatments for various diseases. The roles of extracellular vesicles in inflammatory eye disorders have been widely investigated in recent years. The term “inflammatory eye diseases” refers to a variety of eye conditions such as inflammation-related diseases, degenerative conditions with remarkable inflammatory components, neuropathy, and tumors. This study presents an overview of extracellular vesicles’ and exosomes’ pathogenic, diagnostic, and therapeutic values in inflammatory eye diseases, as well as existing and potential challenges.

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Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light‐Induced Phototoxicity

Kwon,

Munsoor,

Kaufmann

et al. 2024

Advanced Science

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Exposure of the eyes to blue light can induce the overproduction of reactive oxygen species (ROS) in the retina and retinal pigment epithelium (RPE) cells, potentially leading to pathological damage of age‐related macular degeneration (AMD). While the melanin in RPE cells absorbs blue light and prevents ROS accumulation, the loss and dysfunction of RPE melanin due to age‐related changes may contribute to photooxidation toxicity. Herein, a novel approach utilizing a polydopamine‐replenishing strategy via a single‐dose intravitreal (IVT) injection is presented to protect retinal cells against blue light‐induced phototoxicity. To investigate the effects of overexposure to blue light on retinal cells, a blue light exposure Nrf2‐deficient mouse model is created, which is susceptible to light‐induced retinal lesions. After blue light irradiation, retina degeneration and an overproduction of ROS are observed. The polydopamine‐replenishing strategy demonstrated effectiveness in maintaining retinal structural integrity and preventing retina degeneration by reducing ROS production in retinal cells and limiting the phototoxicity of blue light exposure. These findings highlight the potential of polydopamine as a simple and effective replenishment for providing photoprotection against high‐energy blue light exposure.

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Inflammation and retinal degenerative diseases

Cited by 30 publications

References 78 publications

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: A narrative review of the literature

Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light‐Induced Phototoxicity

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