Inflammation and the chemical carcinogen benzo[a]pyrene: Partners in crime

Shi, Quan; Godschalk, Roger; Schooten, Frederik J. van

doi:10.1016/j.mrrev.2017.08.003

Cited by 60 publications

(34 citation statements)

References 176 publications

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“…Recently, Shi et al [75] postulated that lung inflammation and B(a)P are partners in lung tumorigenesis. Cancer-related inflammation facilitates resistance to cell growth inhibition, escape from apoptosis, enhanced angiogenesis, tumor extravasation and finally metastasis [76].…”

Section: Discussionmentioning

confidence: 99%

Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis

et al. 2019

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One of the major etiological factors that account for lung cancer is tobacco use. Benzo(a)pyrene [B(a)P], one of the main constituents of tobacco smoke, has a key role in lung carcinogenesis. The present study was conducted to investigate the cytotoxicity of an aqueous ethanolic extract of Lagerstroemia speciosa (L.) Pers leaves (LLE) on human lung adenocarcinoma cells (A549), as well as its in vivo antitumor effect on a lung tumorigenesis mice model. Our results revealed that LLE possesses cytotoxic activity against the A549 cell line. Mice orally administered B(a)P (50 mg/kg body weight) showed an increase in relative lung weight with subsequent decrease in final body weight. Serum levels of tumor marker enzymes AHH, ADA and LDH and the inflammatory mediator NF-κB increased, while total antioxidant capacity (TAC) decreased. In addition, we observed the increased activity of metalloproteinases (MMP-2 and MMP-12) and levels of the tumor angiogenesis marker VEFG and the lipid peroxidation marker MDA, as well as decreased levels of the non-enzymatic antioxidant GSH and enzymatic antioxidants CAT and GSH-Px in lung tissues. Moreover, B(a)P administration up-regulated the expression of the COX-2 gene, pro-inflammatory cytokines TNF-α and IL-6, and an anti-apoptotic gene Bcl-2, and at the same time down-regulated expression of pro-apoptotic genes BAX and caspase-3 and the p53 gene. Pre- and post-treatment with LLE (250 mg/kg body weight) attenuated all these abnormalities. Histopathological observations verified the protective effect of LLE. Overall, the present data positively confirm the potent antitumor effect of L. speciosa leaves against lung tumorigenesis.

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Section: Discussionmentioning

confidence: 99%

Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis

et al. 2019

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“…isoforms (including CYP1A1). These latter are involved in the metabolic activation of B[a]P in genotoxic metabolites forming DNA adducts relevant for carcinogenesis [for review, (21,22)]. A growing body of evidence is accumulating implicating the B[a]P/AhR/CYP1A1 pathway in carcinogenesis (23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

et al. 2020

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“…Other polycyclic aromatic hydrocarbons than benzo(a)pyrene, such as 3-methylcholanthrene and dioxins, activate the aryl hydrocarbon receptor (ahr) which aggravates ra in smoking patients by differentiating and activating T helper 17 cells. a high ahr expression in the synovial membrane is correlated to smoking habits (20).…”

Section: Benzo(a)pyrenementioning

confidence: 99%

Etiopathogenic mechanisms of tobacco constituents in rheumatoid arthritis

Macovei¹,

Cardoneanu²,

Burlui³

et al. 2019

Ro J Rheumatol.

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Active smoking is considered a risk factor for rheumatoid arthritis. Smokers show respiratory extra-articular manifestations and complications, such as interstitial lung disease and chronic obstructive pulmonary disease. Smokers may receive a more intensive drug therapy than non-smokers, but they have a poor prognosis. Smoker's resistance to therapy may be caused by the pharmacokinetic interactions between drugs and tobacco constituents. The present account of some of those thousands of components of the gas and tar phase of cigarette smoke (polynuclear aromatic hydrocarbons, quinones, cyanide, heavy metals, bacterial endotoxins, nicotine and carbon monoxide) may help explain the inconclusive incrimination of tobacco use in the development of rheumatoid arthritis and convince more clinicians to recommend smoking cessation.

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Inflammation and the chemical carcinogen benzo[a]pyrene: Partners in crime

Cited by 60 publications

References 176 publications

Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis

Lagerstroemia Speciosa (L.) Pers Leaf Extract Attenuates Lung Tumorigenesis via Alleviating Oxidative Stress, Inflammation and Apoptosis

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

Etiopathogenic mechanisms of tobacco constituents in rheumatoid arthritis

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