Inflammation and the Silent Sequelae of Stroke

Becker, Kyra J.

doi:10.1007/s13311-016-0451-5

Cited by 40 publications

(28 citation statements)

References 135 publications

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“…[103][104][105] These studies are quite small, however, and larger studies controlling for baseline comorbidities and stroke characteristics are needed to adequately address the relationship between C-reactive protein and PSF.…”

Section: Inflammation Immune Response and Genesmentioning

confidence: 99%

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Hinkle¹,

Becker²,

Kim³

et al. 2017

Stroke

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142

129

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At least half of all stroke survivors experience fatigue; thus, it is a common cause of concern for patients, caregivers, and clinicians after stroke. This scientific statement provides an international perspective on the emerging evidence surrounding the incidence, prevalence, quality of life, and complex pathogenesis of poststroke fatigue. Evidence for pharmacological and nonpharmacological interventions for management are reviewed, as well as the effects of poststroke fatigue on both stroke survivors and caregivers.

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Section: Inflammation Immune Response and Genesmentioning

confidence: 99%

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Hinkle¹,

Becker²,

Kim³

et al. 2017

Stroke

Self Cite

142

129

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“…[21][22][23] Therefore, immune system-mediated inflammation is critically involved in determining the fate of the brain following ischemic stroke. [24][25][26] Understanding the mechanisms underlying role of neuroinflammation in ischemic stroke would provide important targets for the development of therapy in ischemic stroke.…”

Section: Introductionmentioning

confidence: 99%

Role of neuroinflammation in ischemic stroke

Li¹,

Pan²,

Tang³

et al. 2017

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Ischemic stroke causes the depletion of energy and induce excitotoxicity and neuroinflammation in the brain that results from thrombotic blockage. Neuroinflammation occurs initially depending on activated resident microglia that has the same function as the macrophage. Activated microglia participates in the neuroinflammatory process by phagocytosing the injured brain cells and producing the pro-and anti-inflammatory mediators. In this review, the authors present an overview of the role of microglia in mediating neuroinflammation in ischemic stroke. Key words:Microglia, ischemic stroke, neuroinflammation ABSTRACT Topic: StrokeThis is an open access article distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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“…In general, elevations in circulating pro-inflammatory cytokines such as IL-1β, TNF-α, and IL-6 have been linked to larger infarct size and worse prognosis, while the opposite is true for circulating levels of anti-inflammatory cytokines like IL-10 and IL-1RA [69,84]. Becker [27] indicated that overall systemic milieu after stroke, rather than a single cytokine or other biological substrate that cause either PSD or PSF. Despite evidence that stroke induces systemic inflammation and sickness behavior-like symptoms, few studies have examined the association between stroke-induced inflammation and PSF or PSD.…”

Section: Post-stroke Fatigue and Depressionmentioning

confidence: 99%

Inflammatory Signaling in Post-Stroke Fatigue and Depression

et al. 2018

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Background: In the United States, stroke continues to be the cause for long-term disability. Of the patients with a first stroke, up to 75% will experience post-stroke fatigue (PSF) in the first year following stroke. PSF is one of the most disabling symptoms in stroke survivors; it decreases quality of life, increases mortality, and is a barrier to stroke rehabilitation. Given the incidence of stroke and the prevalence and detrimental impact of PSF on quality of life, independent living, and overall survival, efficient management of PSF must be a priority in stroke rehabilitation. The cause of PSF remains unknown. The burden of fatigue in stroke survivors is influenced by other stroke-related symptoms, most notably post-stroke depression (PSD). It is well known that stroke induces a systemic inflammatory response that is the trigger for sickness behavior, of which fatigue and depression are predominant symptoms. Summary: To date, only a handful of studies have sought to explore the relationship between stroke-induced inflammation and PSF and PSD. In this review, we describe this evidence, highlight the strengths and weaknesses of these existing studies, and suggest further experiments that may further support the association between stroke-related inflammatory processes and stroke-related symptoms. Key Messages: The current concept and further research are important for a more specific therapeutic intervention for PSF and PSD.

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Inflammation and the Silent Sequelae of Stroke

Cited by 40 publications

References 135 publications

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Poststroke Fatigue: Emerging Evidence and Approaches to Management: A Scientific Statement for Healthcare Professionals From the American Heart Association

Role of neuroinflammation in ischemic stroke

Inflammatory Signaling in Post-Stroke Fatigue and Depression

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