Inflammation as a potential risk factor for spinal deformities in farmed Atlantic salmon (<i>Salmo salar</i>L.)

Gil-Martens, L.

doi:10.1111/j.1439-0426.2010.01433.x

Cited by 28 publications

(35 citation statements)

References 59 publications

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“…Several genes involved in the immune response were significantly downregulated in molariform LPJs, as shown by our functional annotation analyses, which indicated the overrepresentation of terms such as immune response (7 of 27 genes), response to wounding (5 of 27) and inflammation (4 of 27). This observation is consistent with the proposal that the inflammatory response influences teleost skeletal deformities (Gil‐Martens, ) and with Vieira et al. (), who detected the expression of various immune‐related genes in the bones of gilthead sea bream in response to starvation stress.…”

Section: Transcription During Remodeling Of Teleost Acellular Bonessupporting

confidence: 92%

Molecular investigation of mechanical strain-induced phenotypic plasticity in the ecologically important pharyngeal jaws of cichlid fish

Gunter

Meyer

2014

J. Appl. Ichthyol.

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SummaryPhenotypic plasticity in the form of alterations to teleost skeletons can result from a range of environmental factors, such as the hardness of the prey, particularly when exposure occurs early during development. Determining the molecular underpinnings of teleost skeletal plasticity is hampered by a limited understanding of the molecular basis of bone remod eling in derived teleost fish, whose bones are acellular, lack ing the cell type known to orchestrate bone remodeling in mammals. We are using a fitting molecular model for phenotypic plasticity research: the East African cichlid Astatoreochromis alluaudi, with the aim to shed light on the molecular basis of phenotypic plasticity and on the remodel ing of acellular bones. For this fish, sustained ingestion of a hard diet induces a 'molariform' lower pharyngeal jaw (LPJ), with molar like teeth set in an enlarged, relatively dense jaw, while a softer diet results in a smaller, finer 'papilliform' LPJ morphology, representing the 'ground state' for this species. Through comparing genome wide transcription in molari form and papilliform LPJs, our previous research has shed light on the molecular basis of phenotypic plasticity in the teleost skeleton and by extension, on acellular bone remodel ing. In this manuscript we construct a model for the molecu lar basis of mechanically induced skeletal plasticity in teleosts, which involves iterative cycles of strain and compen satory cellular proliferation. Furthermore, we propose a framework for testing the potential influence of phenotypic plasticity and genetic assimilation on adaptive radiations.

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Section: Transcription During Remodeling Of Teleost Acellular Bonessupporting

confidence: 92%

Molecular investigation of mechanical strain-induced phenotypic plasticity in the ecologically important pharyngeal jaws of cichlid fish

Gunter

Meyer

2014

J. Appl. Ichthyol.

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“…In addition, multiple stressful handling procedures, usually occurring in intensive farming conditions of salmon aquaculture, can cause extreme mechanical loading to the spine, which may potentially induce local inflammation leading to changes in the normal pattern of growth and remodelling of the spine, that end in a spinal deformity [38][39][40] .…”

Section: Discussionmentioning

confidence: 99%

Spinal deformities in a wild line of Poecilia wingei bred in captivity: report of cases and review of the literature

Arbuatti¹,

Salda

Romanucci

2013

Asian Pacific Journal of Tropical Biomedicine

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“…Kvellestad et al. (2000) and Gil‐Martens (2010) suggested the involvement of inflammatory processes. Although, Fjelldal et al.…”

Section: Causes and Pathogenesis Of Vertebral Deformitiesmentioning

confidence: 99%

Vertebral deformities in farmed Atlantic salmon (Salmo salar L.) - etiology and pathology

Fjelldal

Hansen

Breck³

et al. 2012

Journal of Applied Ichthyology

106

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Summary The present review sums up and discusses the current literature on occurrence, causation and pathology of vertebral deformities in farmed Atlantic salmon, and also gives a brief introduction into the normal ontogeny and anatomy of the vertebral column of Atlantic salmon. Skeletal development and growth are sensitive processes that can be affected by many factors. Many of these factors can be manipulated under farming conditions, and are thus regarded as risk factors. Several risk factors that relate to environmental conditions and to feed composition have been identified. Elevated temperatures and photoperiod manipulation to speed up growth are likely the most important environmental factors that cause skeletal deformities. Among the nutritional factors, optimal phosphorus nutrition during specific periods, for example after transfer to sea water, appears to be critical for development of deformity at later stages. More research is needed to understand the interdependency of genetics, development, aging, phosphorus nutrition, temperature and photoperiod, in order to establish the best practice procedures for salmon farming that improve fish welfare.

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Inflammation as a potential risk factor for spinal deformities in farmed Atlantic salmon (Salmo salarL.)

Cited by 28 publications

References 59 publications

Molecular investigation of mechanical strain-induced phenotypic plasticity in the ecologically important pharyngeal jaws of cichlid fish

Molecular investigation of mechanical strain-induced phenotypic plasticity in the ecologically important pharyngeal jaws of cichlid fish

Spinal deformities in a wild line of Poecilia wingei bred in captivity: report of cases and review of the literature

Vertebral deformities in farmed Atlantic salmon (Salmo salar L.) - etiology and pathology

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