2015
DOI: 10.1038/mp.2015.22
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Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

Abstract: This study explores whether inflammatory biomarkers act as moderators of clinical response to omega-3 (n-3) fatty acids in subjects with Major Depressive Disorder (MDD). 155 subjects with DSM-IV MDD, a baseline 17-item Hamilton Depression Rating Scale (HAM-D-17) score ≥ 15 and baseline biomarker data (IL-1ra, IL-6, hs-CRP, leptin, adiponectin), were randomized between 05/18/06 and 06/30/11, to 8 weeks of double-blind treatment with eicosapentaenoic acid (EPA)-enriched n-3 1060 mg/day, docosahexaenoic acid (DHA… Show more

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Cited by 239 publications
(197 citation statements)
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“…Moreover, Rapaport et al had reported that 'high' inflammation group, including higher levels of CRP, of patients with MDD responded better to EPA treatment when compared to the 'low' inflammation group in MDD [43]. Hence, BanI GG genotype with an elevated CRP level in MDD may be an indicator for better response to EPA treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, Rapaport et al had reported that 'high' inflammation group, including higher levels of CRP, of patients with MDD responded better to EPA treatment when compared to the 'low' inflammation group in MDD [43]. Hence, BanI GG genotype with an elevated CRP level in MDD may be an indicator for better response to EPA treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Of the two studies that have considered baseline inflammation status, both studies used baseline inflammation as a predictor of response in patients with major depressive disorder in post hoc analysis (Raison et al, 2013b;Rapaport et al, 2015). In each case, increased peripheral blood inflammatory markers including CRP at baseline were predictors of response.…”
Section: Enrich For Patients Based On Peripheral Immune Markersmentioning
confidence: 99%
“…Omega-3 fatty acids have been extensively studied as antidepressants, with meta-analyses demonstrating significant antidepressant efficacy especially for eicosapentaenoic acid (EPA) (Mocking et al, 2016). Relevant to the immune system, in a recent study it was demonstrated that patients with a compilation of inflammatory markers including increased CRP and IL-1ra had a greater antidepressant response to EPA, whereas individuals with increased CRP and IL-6 were less responsive to placebo (Rapaport et al, 2015). These data extend the current literature on the antidepressant effects of omega-3 fatty acids to potentially include an anti-inflammatory component that is currently under investigation (see NCT02553915).…”
Section: Reviewmentioning
confidence: 99%
“…In mood disorders, several studies have suggested that the chronic mild inflammation indicated by elevated C-reactive protein (Courtet et al, 2015;Rapaport et al, 2015;Uher et al, 2014) as well as the quantification of the levels of inflammatory cytokines such as IL-6, IL-10 and TNF (de Witte et al, 2014;Ducasse et al, 2015b;Haapakoski et al, 2015;Halaris et al, 2015;Rethorst et al, 2013) could prove to be useful biomarkers for improved diagnosis and the detection of treatment refractoriness (Strawbridge et al, 2015), as well as indicators of the risk of suicide. As an increasing number of inflammatory factors are tested, an emerging picture supports the idea that a complex network of cytokines is involved in the pathophysiology of disease such as major depression (Dahl et al, 2014).…”
Section: Introductionmentioning
confidence: 99%