Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

Rooyen, Yolandi van; Schutte, Aletta E.; Huisman, Hugo W.; Eloff, Fritz C.; Plessis, Johan du; Kruger, Annamarie; Rooyen, Johannes M. Van

doi:10.1007/s00408-015-9804-9

Cited by 14 publications

(13 citation statements)

References 63 publications

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“…We suggest that a reduction in either FEV 1 or FVC and an increase in IL-6 is so closely correlated that the inclusion of IL-6 into our multivariate Cox regression model eliminated the association between FVC and CV risk. We have previously shown a highly significant inverse association between IL-6 and both FEV 1 and FVC (both P < 0Á001) in this population [34]. This finding supports previous studies that showed a stronger relationship between IL-6 and lung function, when compared to other inflammation markers such as CRP and TNF-ɑ [35].…”

Section: Discussionsupporting

confidence: 89%

Lung function, inflammation and cardiovascular mortality in Africans

Breet

Schutte

Huisman

et al. 2016

Eur J Clin Investigation

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Section: Discussionsupporting

confidence: 89%

Lung function, inflammation and cardiovascular mortality in Africans

Breet

Schutte

Huisman

et al. 2016

Eur J Clin Investigation

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“…Inflammatory mediators and cytokines produced by tumors or a host's innate response can exert immunomodulatory effects through apoptosis inhibition, DNA damage, and angiogenesis promotion [15]. Moreover, recent data showed that elevated SIR may contribute to impaired pulmonary function not only in patients with pulmonary disease and smokers but also in healthy individuals and non-smokers [11, 12, 16, 17]. The systemic effects of cancer-related inflammation can be quantified using routinely available serum SIR biomarkers, such as NLR, PLR, and LMR.…”

Section: Discussionmentioning

confidence: 99%

Preoperative pulmonary function correlates with systemic inflammatory response and prognosis in patients with non-small cell lung cancer: results of a single-institution retrospective study

Gao

Zhang

et al. 2016

Oncotarget

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This study aimed at analyzing the relationship between preoperative pulmonary function and systemic inflammatory response (SIR) biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer (NSCLC). Furthermore, the prognostic significance of these markers was also examined. The medical records of 358 NSCLC patients, who underwent curative lung resection, were retrospectively analyzed. Pulmonary function test values <80% of the predicted values were used to indicate impairment. A receiver operating characteristic curve was used to determine the thresholds of the SIR biomarkers. Univariate and multivariate survival analyses were then performed to identify the factors associated with the overall survival (OS). Furthermore, one prognostic model based on independent prognostic factors was established to classify the patients into low-, intermediate-, and high-risk groups. Results demonstrated that, preoperative forced vital capacity (FVC) was simultaneously associated with NLR, PLR, and LMR (P < 0.05). Multivariate analysis identified age, lymph node status, FVC, and NLR as independent prognostic factors for OS. A subgroup analysis showed that the prognostic value of FVC was independent of age, lymph node status, and NLR. The five-year OS rates for low-, intermediate-, and high-risk groups of prognostic model were 60.9%, 35.9%, and 15.3%, respectively (P < 0.05). Overall, preoperative FVC was an independent prognostic predictor of NSCLC. Significant correlations were observed among preoperative pulmonary function, SIR, and prognosis. Thus, the prognostic model may help us identify risk populations with NSCLC.

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“…Possible mechanisms include inflammation, as arterial stiffness is markedly increased in patients with chronic obstructive pulmonary disease (COPD), a condition characterized by airflow obstruction and inflammation [15–17]. While systemic inflammation, weight, smoking history, hypercholesterolemia, hypertension and diabetes have all been implicated, they do not fully account for the relationship between pulmonary function and arterial stiffness, suggesting that other factors could be involved [9, 13, 18].…”

Section: Introductionmentioning

confidence: 99%

Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner

et al. 2019

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ObjectiveTo investigate age-associated changes in airway microbiome composition and their relationships with lung function and arterial stiffness among genetically matched young and elderly pairs.MethodsTwenty-four genetically linked family pairs comprised of younger (≤40 years) and older (≥60 years) healthy participants were recruited (Total n = 48). Lung function and arterial stiffness (carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx)) were assessed. Sputum samples were collected for targeted 16S rRNA gene amplicon sequencing and correlations between microbiome composition, lung function and arterial stiffness were investigated.ResultsElderly participants exhibited reductions in lung function (FEV1 (p<0.001), FVC (p<0.001) and percentage FEV1/FVC (p = 0.003)) and a 1.3–3.9-fold increase in arterial stiffness (p<0.001) relative to genetically related younger adults. Elderly adults had a higher relative abundance of Firmicutes (p = 0.035) and lower relative abundance of Proteobacteria (p = 0.014), including specific genera Haemophilus (p = 0.024) and Lautropia (p = 0.020) which were enriched in the younger adults. Alpha diversity was comparable between young and elderly pairs (p>0.05) but was inversely associated with lung function (FEV1%Predicted and FVC %Predicted) in the young (p = 0.006 and p = 0.003) though not the elderly (p = 0.481 and p = 0.696). Conversely, alpha diversity was negatively associated with PWV in the elderly (p = 0.01) but not the young (p = 0.569). Specifically, phylum Firmicutes including the genus Gemella were correlated with lung function (FVC %Predicted) in the young group (p = 0.047 and p = 0.040), while Fusobacteria and Leptotrichia were associated with arterial stiffness (PWV) in the elderly (both p = 0.004).ConclusionAgeing is associated with increased Firmicutes and decreased Proteobacteria representation in the airway microbiome among a healthy Asian cohort. The diversity and composition of the airway microbiome is independently associated with lung function and arterial stiffness in the young and elderly groups respectively. This suggests differential microbial associations with these phenotypes at specific stages of life with potential prognostic implications.

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Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function

Abstract: Reduced lung function was associated with increased inflammation and arterial stiffness. The lack of association between arterial stiffness and inflammatory markers suggests that inflammation may not be the mediating link between lung and vascular function in this population.

Cited by 14 publications

References 63 publications

Lung function, inflammation and cardiovascular mortality in Africans

Lung function, inflammation and cardiovascular mortality in Africans

Preoperative pulmonary function correlates with systemic inflammatory response and prognosis in patients with non-small cell lung cancer: results of a single-institution retrospective study

Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner

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