Inflammation-based prognostic score, prior to neoadjuvant chemoradiotherapy, predicts postoperative outcome in patients with esophageal squamous cell carcinoma

Kobayashi, Takashi; Teruya, Masanori; Kishiki, Tomokazu; Endo, Daisuke; Takenaka, Yasuhiro; Tanaka, Hozumi; Miki, Kenji; Kobayashi, Kaoru; Morita, Koji

doi:10.1016/j.surg.2008.08.015

Cited by 90 publications

(72 citation statements)

References 29 publications

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“…The significant correlation between postoperative pathological tumor parameters and prognosis has been well characterized and the grade of the primary tumor response has a prognostic significance (10,11), as does pathological stage (1,(12)(13)(14). In the present study, among postoperative parameters, pathological stage was significantly correlated with prognosis, whereas the primary tumor response was not identified as a significant prognostic factor.…”

Section: Discussioncontrasting

confidence: 39%

Time course of serum C-reactive protein levels during induction chemoradiotherapy and its correlation with treatment response and survival in patients with advanced esophageal squamous cell carcinoma

Fujiwara

Shiozaki

Furutani

et al. 2013

Molecular and Clinical Oncology

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Abstract. Preoperative serum C-reactive protein (CRP) levels have been shown to be of prognostic significance in patients with advanced esophageal carcinoma. However, the clinical significance of serum CRP levels in patients with unresectable or marginally resectable tumors in the absence of induction therapy has not been fully elucidated in relation to treatment response and prognosis. Thirty-four patients with clinical T3-T4 esophageal squamous cell carcinoma who underwent induction chemoradiotherapy (CRT) followed by esophagectomy were enrolled in this retrospective study. Serum CRP levels were measured during the course of CRT, i.e., prior to, during (1, 2, 3 and 4 weeks following initiation) and after CRT (prior to surgery). The association between CRP levels, CRT response and survival was analyzed. Elevated serum CRP levels exhibited a favorable decrease 2-3 weeks following CRT initiation in pathological responders and CRP ≤0.3 mg̸dl at 2 and 3 weeks following CRT initiation, as well as prior to surgery, was significantly correlated with responders. In patients with pretreatment CRP >0.3 mg/dl (67.6% of patients in this study), CRP ≤0.3 mg/dl at 2 and 3 weeks following CRT initiation predicted responders with accuracies of 87.0 and 73.9%, respectively. In the univariate survival analysis, CRP levels 3 weeks following CRT initiation, as well as CRP levels prior to surgery and pathological stage, were significant prognostic factors, although CRP levels prior to surgery was the only independent prognostic factor in the multivariate analysis. Serum CRP levels during the course of CRT may be of prognostic and predictive significance for the CRT response in patients with unresectable or marginally resectable esophageal squamous cell carcinoma who undergo induction CRT.

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Section: Discussioncontrasting

confidence: 39%

Time course of serum C-reactive protein levels during induction chemoradiotherapy and its correlation with treatment response and survival in patients with advanced esophageal squamous cell carcinoma

Fujiwara

Shiozaki

Furutani

et al. 2013

Molecular and Clinical Oncology

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“…Hypoalbuminemia is often observed in patients with advanced cancer and is usually considered to be a marker of malnutrition and cachexia. It has also been reported that albumin is involved in SIR and survival in various types of cancer (11,12). Although pretreatment NLR and PLR have been shown to predict outcome in gynecological cancers, such as endometrial (13,14), cervical (15,16) and ovarian cancer (17,18), PNI has not been shown to be a predictive factor in patients with cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Pretreatment prognostic nutritional index is a significant predictor of prognosis in patients with cervical cancer treated with concurrent chemoradiotherapy

Haraga

Nakamura

Omichi

et al. 2016

Molecular and Clinical Oncology

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Abstract. This study investigated whether pretreatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic nutritional index (PNI) are prognostic factors in patients with cervical cancer who undergo concurrent chemoradiotherapy (CCRT) and radiotherapy (RT). A total of 131 patients who underwent CCRT and RT for cervical cancer were retrospectively investigated and the correlations of NLR, PLR and PNI with clinical parameters and prognosis were assessed in CCRT and RT. The CCRT and RT groups had a median progression-free survival (PFS) of 41.82 and 24.72 months, respectively, and an overall survival of 49.70 and 29.56 months, respectively. At a cut-off value of NLR≥2.85, the PFS and OS in patients with higher NLR undergoing RT were significantly shorter compared with those in patients with lower NLR (P=0.029 and P=0.017, respectively). At a cut-off value for PNI of ≤48.55 in patients undergoing CCRT and ≤45.80 in patients undergoing RT, the PFS and OS in patients with lower PNI were significantly shorter compared with those in patients with higher PNI (PFS and OS with CCRT, P<0.001 and P<0.001, respectively; PFS and OS with RT, P=0.002 and P=0.008, respectively). Multivariate analyses also identified low PNI as an independent prognostic factor for PFS and OS in patients receiving CCRT. Therefore, low PNI was shown to predict poor prognosis in patients with cervical cancer.

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“…Systemic inflammatory response, as evidenced by the GPS, as a prognostic factor in patients with cancer [14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

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confidence: 99%

Systemic inflammation, nutritional status and survival in patients with cancer

McMillan¹

2009

Current Opinion in Clinical Nutrition and Metabolic Care

890

681

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2 Purpose of the ReviewThere is now good evidence in humans that a chronic systemic inflammatory response results in the cardinal features of cancer cachexia, principally the progressive loss of weight (in particular lean tissue). This review examines the role of recent simple objective systemic inflammation-based scores in predicting reduction of nutritional status and survival. Recent findingsThe most common measure of the systemic inflammatory response in cancer patients has been an elevated C-reactive protein concentration. This has now been included in recent definitions of cancer cachexia. There are also recent systemic inflammation-based scores, the Glasgow Prognostic Score, Neutrophil Lymphocyte Ratio and the Platelet Lymphocyte ratio which have been shown to have prognostic value in cancer patients. These scores, in particular the Glasgow Prognostic Score, enable identification of patients who are or likely to develop cachexia, have a poor response to treatment and who are likely to have poor survival. SummaryA chronic systemic inflammatory response is clearly implicated in the progressive nutritional and functional decline of the cancer patient and their subsequent poor outcome.Systemic inflammation-based prognostic scores not only identify patients at risk but also provide well defined therapeutic targets for future clinical trials targeting nutritional decline.3

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Inflammation-based prognostic score, prior to neoadjuvant chemoradiotherapy, predicts postoperative outcome in patients with esophageal squamous cell carcinoma

Cited by 90 publications

References 29 publications

Time course of serum C-reactive protein levels during induction chemoradiotherapy and its correlation with treatment response and survival in patients with advanced esophageal squamous cell carcinoma

Time course of serum C-reactive protein levels during induction chemoradiotherapy and its correlation with treatment response and survival in patients with advanced esophageal squamous cell carcinoma

Pretreatment prognostic nutritional index is a significant predictor of prognosis in patients with cervical cancer treated with concurrent chemoradiotherapy

Systemic inflammation, nutritional status and survival in patients with cancer

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