Inflammation does not influence arterial stiffness and pulse-wave velocity in patients with coronary artery disease

Abstract

Vascular function is an important pathophysiological factor in cardiovascular disease, and is influenced by many factors, one of the principles being hypertension. Developing evidence suggests that inflammation may be another risk factor. Vascular function and blood pressure haemodynamics can be assessed by arterial stiffness, pulse pressure and plasma markers. Testing the hypothesis of a relationship between inflammatory markers, hypertension and vascular function, we recruited 222 stable coronary artery disease outpatients, assessing inflammation with levels of high sensitivity CRP and interleukin-6 (IL-6), vascular function/arterial stiffness by pulse-wave velocity (PWV), augmentation (SphygmoCor system Artcor, Sidney, Australia), aortic and brachial artery pulse pressure, Von Willebrand factor (vWf) and soluble E-selectin (both enzyme-linked immunosorbent assay). In multivariate regression analysis, PWVs, augmentation indices and pulse pressures were linked with age, blood pressure and (some) with heart rate (all P<0.01), while vWf was associated with age (P=0.01). We conclude that, in patients with stable coronary artery disease, arterial stiffness and pulse pressure are related strongly and independently with age, blood pressure and heart rate, and that any effect of inflammation is minimal.

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

“…Peripheral vascular dysfunction has been reported to be influenced by many factors including adiposity [ 17 ], blood pressure [ 18 ], age [ 18 ], physical activity [ 19 ] and inflammatory biomarkers such as C-reactive protein [ 20 ], which are also associated with pulmonary function. Thus the association between vascular dysfunction and pulmonary function could be influenced by, or depend on these factors.…”

Arterial stiffness and atherosclerosis in systemic lupus erythematosus patients

“…The correlation of arterial stiffness, as a marker of early atherosclerosis, with the severity of systemic inflammation has been studied [31,32], but the studies are not consistent. Blann et al [31] found that arterial stiffness was not related to inflammation. But his research was conducted among patients with stable coronary artery disease.…”

Increased Systemic Inflammation is Associated with Cardiac and Vascular Dysfunction over the First 12 Weeks of Antiretroviral Therapy among Undernourished, HIV-Infected Adults in Southern Africa

“…[38]. However, two recent studies suggest that both systemic and vascular inflammation are not major determinants of arterial stiffness as measured by AI [39, 40]. Furthermore, the median baseline peripheral AI value of 11.9 in our cohort was approximately half the mean value of 21.4 measured using the EndoPAT device in a cohort of healthy black Americans, and the increase in AI we observed may represent a return to a more normal physiologic state on ART rather than a pathologic stiffening of the vasculature related to cardiovascular disease [19].…”