Inflammation-Driven Colorectal Cancer Associated with Colitis: From Pathogenesis to Changing Therapy

Nardone, Olga Maria; Zammarchi, Irene; Santacroce, Giovanni; Ghosh, Subrata; Iacucci, Marietta

doi:10.3390/cancers15082389

Cited by 19 publications

(6 citation statements)

References 115 publications

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“…Patients with long-standing UC and colonic Crohn's disease (CD) have a 2-fold increased risk of developing CRC [10]. However, detecting dysplasia in the context of IBD is particularly challenging due to inflammation, and dysplastic lesions associated with Diagnostics 2023, 13, 2547 2 of 18 IBD tend to be more frequently subtle and flat [11].…”

Section: Next-generation Endoscopy In Ibdmentioning

confidence: 99%

Next-Generation Endoscopy in Inflammatory Bowel Disease

Zammarchi,

Santacroce,

Iacucci

2023

Diagnostics

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Endoscopic healing is recognized as a primary treatment goal in Inflammatory Bowel Disease (IBD). However, endoscopic remission may not reflect histological remission, which is crucial to achieving favorable long-term outcomes. The development of new advanced techniques has revolutionized the field of IBD assessment and management. These tools can accurately assess vascular and mucosal features, drawing endoscopy closer to histology. Moreover, they can enhance the detection and characterization of IBD-related dysplasia. Given the persistent challenge of interobserver variability, a more standardized approach to endoscopy is warranted, and the integration of artificial intelligence (AI) holds promise for addressing this limitation. Additionally, although molecular endoscopy is still in its infancy, it is a promising tool to forecast response to therapy. This review provides an overview of advanced endoscopic techniques, including dye-based and dye-less chromoendoscopy, and in vivo histological examinations with probe-based confocal laser endomicroscopy and endocytoscopy. The remarkable contribution of these tools to IBD management, especially when integrated with AI, is discussed. Specific attention is given to their role in improving disease assessment, detection, and characterization of IBD-associated lesions, and predicting disease-related outcomes.

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Section: Next-generation Endoscopy In Ibdmentioning

confidence: 99%

Next-Generation Endoscopy in Inflammatory Bowel Disease

Zammarchi,

Santacroce,

Iacucci

2023

Diagnostics

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“…However, chemotherapy drugs such as 5-fluorouracil (5-FU), folinic acid, oxaliplatin and capecitabine are usually used for patients with stage II colorectal cancer. And patients with stage III and IV colorectal cancer are usually treated with chemotherapy and targeted therapy [ 260 , 261 ]. For IBD-associated CRC, anti-inflammatory therapy in IBD patients may be an effective way to prevent CAC [ 261 ].…”

Section: Therapies For Ibd-associated Crcmentioning

confidence: 99%

“…And patients with stage III and IV colorectal cancer are usually treated with chemotherapy and targeted therapy [ 260 , 261 ]. For IBD-associated CRC, anti-inflammatory therapy in IBD patients may be an effective way to prevent CAC [ 261 ].…”

Section: Therapies For Ibd-associated Crcmentioning

confidence: 99%

Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota

Li,

Ji,

Chen

et al. 2023

Cell Biosci

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Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD). Intestinal epithelial cells (IECs), intestinal mesenchymal cells (IMCs), immune cells, and gut microbiota construct the main body of the colon and maintain colon homeostasis. In the development of colitis and colitis-associated carcinogenesis, the damage, disorder or excessive recruitment of different cells such as IECs, IMCs, immune cells and intestinal microbiota play different roles during these processes. This review aims to discuss the various roles of different cells and the crosstalk of these cells in transforming intestinal inflammation to cancer, which provides new therapeutic methods for chemotherapy, targeted therapy, immunotherapy and microbial therapy.

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“…Inflammation is pivotal in CRC pathogenesis, from the inception of aberrant crypt foci to advanced metastatic disease [ 2 , 3 , 4 , 5 ]. It not only fuels the initiation and progression of CRC but also fundamentally shapes the tumor microenvironment and the immune response to the tumor [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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Inflammation-Driven Colorectal Cancer Associated with Colitis: From Pathogenesis to Changing Therapy

Cited by 19 publications

References 115 publications

Next-Generation Endoscopy in Inflammatory Bowel Disease

Next-Generation Endoscopy in Inflammatory Bowel Disease

Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

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