Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients

Vila, Virtudes; Martínez‐Sales, Vicenta; Almenar, Luís; Lázaro, Ignacio Sánchez; Villa, Piedad; Regañón, Edelmiro

doi:10.1016/j.ijcard.2007.07.010

Cited by 47 publications

(40 citation statements)

References 8 publications

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“…The pathophysiological concept of heart failure has changed dramatically during the last decade with increased understanding of a multiorgan neurohormonal response (1,2 ) as well as activation of immunological (3,4 ) and inflammatory systems (5)(6)(7). As a consequence, new biomarkers for diagnosis and prognosis in heart failure have emerged (8 -10 ).…”

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confidence: 99%

Prognostic Assessment of Elderly Patients with Symptoms of Heart Failure by Combining High-Sensitivity Troponin T and N-Terminal Pro–B-Type Natriuretic Peptide Measurements

et al. 2010

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BACKGROUND N-terminal pro–B-type natriuretic peptide (NT-proBNP) is a useful biomarker in heart failure assessment, whereas measurement of cardiac troponin is central in the diagnosis of patients with acute coronary syndromes. This report examined the prognostic use of combining high-sensitivity cardiac troponin T (hs-cTnT) and NT-proBNP measurements in elderly patients presenting to a primary care center with symptoms associated with heart failure. METHODS A total of 470 elderly patients (age range 65–86 years) presenting with symptoms of heart failure were recruited from primary healthcare. In addition to clinical examination and echocardiography, hs-cTnT and NT-proBNP plasma concentrations were measured. All patients were followed for 10 years, and cardiovascular mortality was registered. RESULTS By use of the hs-cTnT assay, 80.4% of the population had plasma concentrations above the lower detection limit of the assay. Of those displaying a plasma concentration of hs-cTnT >99th percentile of a healthy population, 43% also had an NT-proBNP concentration in the fourth quartile (>507 ng/L). In the multivariate analysis, we observed a 2.5-fold increased risk for cardiovascular mortality in individuals with a plasma NT-proBNP concentration >507 ng/L (P < 0.0001). Conversely, patients with hs-cTnT >99th percentile displayed an approximately 2-fold increased risk for cardiovascular mortality (P = 0.0002). Combining the 2 biomarkers, NT-proBNP concentrations >507 ng/L with hs-cTnT >99th percentile increased the risk 3-fold, even after adjustment for clinical variables such as age, sex, impaired estimated glomerular filtration rate, and anemia (P < 0.0001). CONCLUSIONS hs-cTnT and NT-proBNP measurements combined provide better prognostic information than using either biomarker separately in elderly patients with symptoms associated with heart failure.

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confidence: 99%

Prognostic Assessment of Elderly Patients with Symptoms of Heart Failure by Combining High-Sensitivity Troponin T and N-Terminal Pro–B-Type Natriuretic Peptide Measurements

et al. 2010

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“…In a study that showed vitamin C in addition to Satureja Khuzestanica is effective in preventing abdominal adhesions during the adhesions process [36]. Also, research has shown that Satureja Khuzestanica is effective in preventing atherosclerosis, atherosclerosis is a direct correlation with angiogenesis, that the present study is approving [36,37]. Therefore probably Satureja Khuzistanica with high antioxidant property cannot be useful in wound healing.…”

Section: Discussionmentioning

confidence: 67%

Wound Healing Effect of Satureja Khuzistanica and Satureja Rechingeri Ethanolic Extracts in NMRI Adult Mice

Sahraei

Gharzi

Amiri

et al. 2016

Zahedan J Res Med Sci

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“…Es konnte nachgewiesen werden, dass bei chronischer Herzinsuffizienz eine Immunaktivierung vorliegt und dies zur Progression der Erkrankung beitragen könnte [17]. Erhöhte Konzentrationen von CRP und Zytokinen wie Tumornekrosefaktor α (TNF-α) und Interleukin 6 (IL-6) sind mit einer schlechteren kardiovaskulären Prognose assoziiert [17,19]. Als Ursache der Immunaktivierung bei Patienten mit Herzinsuffizienz wurden verschiedene Hypothesen diskutiert.…”

Section: Folgen Des Venösen Rückstaus Anunclassified

Kardiovaskuläre Erkrankungen: Folgen für den Gastrointestinaltrakt

et al. 2011

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Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients

Cited by 47 publications

References 8 publications

Prognostic Assessment of Elderly Patients with Symptoms of Heart Failure by Combining High-Sensitivity Troponin T and N-Terminal Pro–B-Type Natriuretic Peptide Measurements

Prognostic Assessment of Elderly Patients with Symptoms of Heart Failure by Combining High-Sensitivity Troponin T and N-Terminal Pro–B-Type Natriuretic Peptide Measurements

Wound Healing Effect of Satureja Khuzistanica and Satureja Rechingeri Ethanolic Extracts in NMRI Adult Mice

Kardiovaskuläre Erkrankungen: Folgen für den Gastrointestinaltrakt

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