2012
DOI: 10.1016/b978-0-12-398314-5.00001-5
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Inflammation in Anxiety

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Cited by 266 publications
(170 citation statements)
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References 145 publications
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“…29 Recent work also links low-grade inflammation to gastrointestinal symptoms as well as to anxiety. [30][31][32] It also is possible that anxiety may arise secondary to pain in some individuals and yet serve a maintaining role in pain.…”
Section: Figurementioning
confidence: 99%
“…29 Recent work also links low-grade inflammation to gastrointestinal symptoms as well as to anxiety. [30][31][32] It also is possible that anxiety may arise secondary to pain in some individuals and yet serve a maintaining role in pain.…”
Section: Figurementioning
confidence: 99%
“…hypothalamus-pituitary-adrenal (HPA) axis disturbances; dysregulated inflammatory pathways; increased oxidative and nitrosative stress and reduced antioxidant defences; neuroprogression resulting in neurodegeneration, apoptosis, reduced neurogenesis and neuronal plasticity; and mitochondrial disturbances (Altamura et al, 2013, Anderson et al, 2013a, Anderson et al, 2013b, Moylan et al, 2012, Salim et al, 2012, Vieta et al, 2013. These dysregulated pathways interact significantly with each other, and their translation into specific psychiatric disorders is influenced by other biological mechanisms, environmental factors and genetic polymorphisms.…”
Section: Accepted M Manuscriptmentioning
confidence: 99%
“…Further, psychological stress, specifically, modulates cytokines production. While cytokines are responsible for regulatory central nervous system functions and hence resulting behaviors, the potential relevance of cytokines to one's mental health is strongly correlated [24]. Over time stress causes disruptions to neural circuitry, neurotransmitter metabolism, neuro-endocrine function and synaptic plasticity [24].…”
Section: The Neurophysiological Effects Of Stress On Caregiversmentioning
confidence: 99%
“…While cytokines are responsible for regulatory central nervous system functions and hence resulting behaviors, the potential relevance of cytokines to one's mental health is strongly correlated [24]. Over time stress causes disruptions to neural circuitry, neurotransmitter metabolism, neuro-endocrine function and synaptic plasticity [24]. What results is dysfunctional cytokine signaling, neuroinflammation and aberrant behaviors affiliated with potential outcomes of depression, anxiety and cognitive dysfunction.…”
Section: The Neurophysiological Effects Of Stress On Caregiversmentioning
confidence: 99%