Inflammation in hemodialysis and their correlation with neutrophi-lymphocite ratio and platelet-lymphocyte ratio.

Valencia, Venice Chávez; Cruz, Citlalli Orizaga de la; Mejía-Rodríguez, Oliva; Castellanos, Sergio Gutiérrez; Lagunas‐Rangel, Francisco Alejandro; Sandoval, Martha Eva Viveros

doi:10.1016/j.nefroe.2016.12.014

Cited by 11 publications

(10 citation statements)

References 7 publications

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“…The study by Chávez Valencia [ 33 ] pointed out that these markers can be used to identify hemodialysis patients with inflammation. Ahbap et al [ 22 ], who worked with 100 patients in stage 5 CKD on maintenance hemodialysis, concluded that both NLR and PLR had higher levels in patients with inflammation.…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Brito

Fontenele

Carneiro

et al. 2021

International Journal of Inflammation

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Background. The Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) are inflammatory biomarkers for several diseases, such as cancer and cardiovascular morbidities; however, there are currently few studies on kidney diseases. We aimed to evaluate nondialysis patients and determine the association of NLR and PLR with inflammation in these patients. Methods. A prospective cross-sectional study was conducted with 85 patients at different stages of chronic kidney disease (CKD), treated at the Kidney Disease Prevention Center of the University Hospital of the Federal University of Maranhão. This study included adult nondialysis patients diagnosed with CKD. The participants’ blood samples were collected for a high-sensitivity C-reactive protein (hs-CRP) test and blood count. They were divided into two groups according to the presence or absence of inflammation based on the hs-CRP value (<0.5 mg/dL). NLR and PLR were calculated based on the absolute number of neutrophils, lymphocytes, and platelets and were compared between them and with hs-CRP. Statistical analysis was performed using the Stata software, with the Shapiro–Wilk, Mann–Whitney, Spearman’s Correlation, and receiver operating characteristic curve tests. This study was approved by the local ethics committee. Results. The participants were categorized into two groups: with inflammation (n = 64) and without inflammation (n = 21). The mean age was 61.43 ± 14.63 y. The NLR and PLR values were significantly different between the groups with and without inflammation ( p = 0.045 and p = 0.004 , respectively). However, only PLR showed a significant positive correlation with hs-CRP ( p = 0.015 ). The best cutoff point for NLR to detect inflammation was 1.98, with 76.19% sensitivity and 48.44% specificity. For PLR, it was 116.07, with 85.71% sensitivity and 51.56% specificity. There was no significant difference between the area under the NLR and PLR curve (0.71 vs. 0.64; p = 0.186 ) for this population. Conclusions. This study showed that PLR was positively correlated with hs-CRP in nondialysis CKD patients and can be used to identify inflammation in this population.

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Section: Discussionmentioning

confidence: 99%

“…Chávez Valencia et al [ 33 ] concluded that PLR is correlated with some inflammatory parameters (CRP and interleukin 6) and was better than NLR in this sense. Okyay et al [ 35 ] found that, in CKD patients, both NLR and PLR correlated positively with other inflammatory markers, such as hs-CPR.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Brito

Fontenele

Carneiro

et al. 2021

International Journal of Inflammation

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“…According to data from the United States Renal Data System (USRDS) in 2019, the MHD mortality rate in 2017 was 167 per 1,000 patient-years [ 1 ]. Studies have shown that 30-50% of MHD patients have chronic inflammation state [ 2 ]. Persistent inflammation can lead to a variety of complications, especially cardiovascular disease, malnutrition and anemia, thereby increasing the mortality of MHD patients [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of the combination of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio on mortality in patients on maintenance hemodialysis

Liao¹,

D²,

Sun³

et al. 2022

BMC Nephrol

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Background Hemodialysis (HD) is the most important renal replacement therapy for patients with end-stage kidney disease (ESKD). Systemic inflammation is a risk factor of mortality in HD patients. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are new inflammatory markers. However, previous studies have inconsistent conclusions about the predictive value of NLR, MLR and PLR on mortality of HD patients. The aim of this study was to establish an inflammation scoring system by including NLR, MLR and PLR, and evaluate the association between the inflammation score and all-cause and cardiovascular mortality in HD patients. Methods In this single center retrospective cohort study, 213 incident HD patients from January 1, 2015 to December 31, 2020 were included. Baseline demographic and clinical data and laboratory measurements were collected. According to the optimal cut-off values, NLR, MLR and PLR were assigned 0 or 1 point, respectively. Then, the inflammation score was obtained by adding the NLR, MLR and PLR scores. All patients were followed until July 31, 2021. The associations of the inflammation score with all-cause and cardiovascular mortality were assessed by multivariable-adjusted Cox models. Results Of 213 patients, the mean (± SD) age was 56.8 ± 14.4 years, 66.2% were men, and 32.9% with diabetes. The primary cause of ESKD was mainly chronic glomerulonephritis (46.5%) and diabetic nephropathy (28.6%). The median inflammation score was 2 (interquartile range = 1–3). During a median 30 months (interquartile range = 17–50 months) follow-up period, 53 patients had died, of which 33 deaths were caused by cardiovascular disease. After adjusting for demographics, primary diseases and other confounders in multivariable model, the inflammation score = 3 was associated with a hazard ratio for all-cause mortality of 4.562 (95% confidence interval, 1.342–15.504, P = 0.015) and a hazard ratio for cardiovascular mortality of 4.027 (95% confidence interval, 0.882–18.384, P = 0.072). Conclusion In conclusion, an inflammation scoring system was established by including NLR, MLR and PLR, and the higher inflammation score was independently associated with all-cause mortality in HD patients.

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“…Inflammation is one of the main pathophysiological factors in PCOS diseases. Nowadays diagnostic and monitoring markers are used, such as C-reactiveprotein (CRP), erythrocyte sedimentation rate, ferritin, serumalbumin, apolipoprotein A-1, tumor necrosis factor, interleukin-1, interleukin-6 and others (7,8) .Chronic inflammation and infection are an important and major cause of cancer,include NF-κB,reactive oxygen species and nitrogen, inflammatory cytokines,prostaglandins,andR NAs,through proliferation changes,cell death,cellular aging,mutation and methylation in DNA (7) .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Neutrophil-to-Lymphocyte Ratio, Platelet-toLymphocyte Ratio,Oxidative Stress and Anti Oxidants levels in Polycystic Ovary Syndrome Patients with Low-Grade Chronic Inflammation

2021

MLU

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Background:The ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR)are prognostic factors in many diseases such as inflammatory diseases, cardiovascular diseases and cancer. However, racing NLR and PLR are important, it is important to establish reference values for NLR and PLR in polycystic ovary syndrome (PCOS) patients with mild chronic inflammation.Objective: To determine the neutrophil-lymphocyte ratio (NLR)and platelet-lymphocyte ratio (PLR), and the relationship between oxidative stress markers and anti oxidants markers in PCOS patients with lowgrade chronic Inflammation. Methodology. The study included 92 patients with PCOS and 46 control. Serum PON1, XO, SOD activities, 8-OHdG and NO levels were measured using enzyme linked immunosorbent assay (ELISA) kits.Results: Concentration of TNF-ɑ, IL-6, IL-8, IL-10 and CRP were significantly higher in PCOS patients compared with control (P<0.001). Significant increases were recorded in WBC, ANC, PLT, NLR, PLR, and ESR values. A significant decrease in ALC and MPV values in PCOS patients compared with control (P<0.01). Serum XO, SOD activities and NOlevels were higher in PCOS patients than in the control (p<0.001). Serum 8-OHdG levels and PON1 activities were lower in PCOS patients than in the control (p<0.001). Serum CRP values is positively correlated with XO, NO, p<0.008; r=0.560, p<0.007; r=0.387, p<0.006; r=0.481, p<0.009), respectively. Serum CRP values is negatively correlated with SOD activity in PCOS patients (r=−0.444, p<0.004).Serum XO activities were negatively correlated with serum PON1 and SOD. Serum XO activities were Positively correlated with serum NO and 8-OHdG levels. Conclusion:Inflammation stimulates the oxidation process and reduces the ability of cellular antioxidants in PCOS patients. NLR and PLR are good markers of inflammation, their highest values indicate the severity of the disease and an imbalance between neutrophils and lymphocytes can be linked to cancer and its development.

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Inflammation in hemodialysis and their correlation with neutrophi-lymphocite ratio and platelet-lymphocyte ratio.

Cited by 11 publications

References 7 publications

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients

Prognostic value of the combination of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio and platelet-to-lymphocyte ratio on mortality in patients on maintenance hemodialysis

Assessment of Neutrophil-to-Lymphocyte Ratio, Platelet-toLymphocyte Ratio,Oxidative Stress and Anti Oxidants levels in Polycystic Ovary Syndrome Patients with Low-Grade Chronic Inflammation

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