Inflammation in obese children and adolescents: Association with psychosocial stress variables and effects of a lifestyle intervention

Verbiest, Ine; Michels, Nathalie; Tanghe, Ann; Braet, Caroline

doi:10.1016/j.bbi.2021.07.020

Cited by 7 publications

(4 citation statements)

References 52 publications

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“…Although family participation and parents acting as role models are highly advocated, anti-obesity drugs and metabolic weight loss surgery are still supplementary therapies[ 1 , 62 ]. In addition, a previous study has reported that CRP in obese children is closely related to psychological variables, thus providing insights into the prevention and treatment of childhood obesity through psychological intervention[ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents: A meta-analysis

Li,

Pang

et al. 2024

World J Diabetes

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BACKGROUND Obesity in children and adolescents is a serious problem, and the efficacy of exercise therapy for these patients is controversial. AIM To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory markers. METHODS The PubMed, Web of Science, and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October 2023. The meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese children. RESULTS In total, 1010 patients from 28 studies were included. Exercise therapy reduced the levels of fasting blood glucose (FBG) [standardized mean difference (SMD): -0.78; 95% confidence interval (CI): -1.24 to -0.32, P = 0.0008], fasting insulin (FINS) (SMD: -1.55; 95%CI: -2.12 to -0.98, P < 0.00001), homeostatic model assessment for insulin resistance (HOMA-IR) (SMD: -1.58; 95%CI: -2.20 to -0.97, P < 0.00001), interleukin-6 (IL-6) (SMD: -1.31; 95%CI: -2.07 to -0.55, P = 0.0007), C-reactive protein (CRP) (SMD: -0.64; 95%CI: -1.21 to -0.08, P = 0.03), and leptin (SMD: -3.43; 95%CI: -5.82 to -1.05, P = 0.005) in overweight and obese children. Exercise training increased adiponectin levels (SMD: 1.24; 95%CI: 0.30 to 2.18, P = 0.01) but did not improve tumor necrosis factor-alpha (TNF-α) levels (SMD: -0.80; 95%CI: -1.77 to 0.18, P = 0.11). CONCLUSION In summary, exercise therapy improves glucose metabolism by reducing levels of FBG, FINS, HOMA-IR, as well as improves inflammatory status by reducing levels of IL-6, CRP, leptin, and increasing levels of adiponectin in overweight and obese children. There was no statistically significant effect between exercise training and levels of TNF-α. Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

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Section: Discussionmentioning

confidence: 99%

Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents: A meta-analysis

Li,

Pang

et al. 2024

World J Diabetes

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“…In addition to being a risk factor for severe childhood COVID-19 illness, 1 the post COVID-18 consequences of social isolation has clearly left many youth far worse off and vulnerable to obesity than pre pandemic times, as well as impacting their mental health negatively. 2,3 As well as the long-term and short term physical and mental health challenges incurred by the overweight or obese youngster, 4 there are multiple obvious adverse impacts of childhood obesity, including its negative impact on academic outcomes, as well as social and possible economic health outcomes and correlates. 5 Considered to be one of the most serious public health challenges of the 21 st century, the dire predictions concerning rates of obesity among children, 5 and that clearly underpins the continuing demonstrated decline in their mental health status among youth, 6 warrants urgent attention.…”

Section: Overviewmentioning

confidence: 99%

Untitled

2022

AOWMC

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As obesity continues to remains an immense challenge to mitigate effectively, efforts to untangle its determinants continue, especially those that may exacerbate or impact childhood obesity, and its predictable and well established negative health impacts. Studied for many years in various spheres, the role played by depression has been discussed for some time in this regard, especially in light of COVID-19 pandemic imperatives and their long term mental health effects on youth. This mini review discusses some of these current ideas and related observations regarding, and whether more emphasis on fostering mental health among youth is indicated in efforts to effectively attenuate the onset and spread of childhood obesity into adulthood. Extracted from current literature, it is concluded that this is a topic of significance, but one requiring more acceptance and recognition, plus dedicated sustainable collaborative goals and supportive efforts.

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“…Eating behaviors stand out as crucial proximal determinants of body weight and the motivation to eat since childhood [6,7]. Eating styles represent dispositional tendencies of food intake and have been closely related to obesity in adults [8] and children and adolescents [9,10]. According to the three main theories about impaired food consumption (i.e., the external, psychosomatic, and restraint theories), three predominant eating styles have been identified [11].…”

Section: Introductionmentioning

confidence: 99%

“…Disentangling the multiple factors involved and the relationships between them can help us better understand obesity and, therefore, develop more effective prevention and treatment methods, especially in the early stages of human development. As pointed out by Verbiest and colleagues [10], interdisciplinary work is needed to do so.…”

Section: Introductionmentioning

confidence: 99%

Are Peripheral Biomarkers Determinants of Eating Styles in Childhood and Adolescence Obesity? A Cross-Sectional Study

et al. 2022

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Disturbances in eating behaviors have been widely related to obesity. However, little is known about the role of obesity-related biomarkers in shaping habitual patterns of eating behaviors (i.e., eating styles) in childhood. The objective of the present study was to explore the relationships between several biomarkers crucially involved in obesity (ghrelin, insulin resistance, and leptin/adiponectin ratio) and eating styles in children and adolescents with obesity. Seventy participants aged between 8 and 16 (56.2% men) fulfilled the Spanish version of the Dutch Eating Behavior Questionnaire for Children to measure external, emotional, and restrained eating styles. In addition, concentrations of ghrelin, leptin, adiponectin, insulin, and glucose were obtained through a blood test. Hierarchical multiple regression analyses controlling for age and sex were computed for each eating style. Results indicated that individuals with higher ghrelin concentration levels showed lower scores in restrained eating (β = −0.61, p < 0.001). The total model explained 32% of the variance of the restrained pattern. No other relationships between obesity-related biomarkers and eating behaviors were found. This study highlights that one of the obesity-risk factors, namely lower plasma ghrelin levels, is substantially involved in a well-known maladaptive eating style, restraint eating, in childhood obesity.

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Inflammation in obese children and adolescents: Association with psychosocial stress variables and effects of a lifestyle intervention

Cited by 7 publications

References 52 publications

Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents: A meta-analysis

Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents: A meta-analysis

Untitled

Are Peripheral Biomarkers Determinants of Eating Styles in Childhood and Adolescence Obesity? A Cross-Sectional Study

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