2011
DOI: 10.1097/jsa.0b013e31820e6a92
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Inflammation in Overuse Tendon Injuries

Abstract: Overuse tendon injuries present with pain and swelling of the affected tendon with associated decrease in exercise tolerance and function of the limb. After early inflammatory and degenerative hypotheses, the term "tendinopathy" is now deemed a more appropriate reflection of the mixed histopathological picture seen in operative biopsies from affected patients. The condition presents histopathological evidence of "failed healing response," but its etiology remains unclear. The incidence of tendinopathy is incre… Show more

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Cited by 93 publications
(65 citation statements)
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“…Finally, isolated tendinosis can occur without paratenonitis. It is thought that this condition results from an early inflammatory infiltrate followed by a failed healing response and ultimately tendon degeneration 29 . Histologically, the tendon has a noninflamed appearance with collagen degeneration, hypocellularity, local necrosis, areas of calcification, and minimal vascular ingrowth 20 .…”
Section: Etiology and Risk Factors For Injurymentioning
confidence: 99%
See 1 more Smart Citation
“…Finally, isolated tendinosis can occur without paratenonitis. It is thought that this condition results from an early inflammatory infiltrate followed by a failed healing response and ultimately tendon degeneration 29 . Histologically, the tendon has a noninflamed appearance with collagen degeneration, hypocellularity, local necrosis, areas of calcification, and minimal vascular ingrowth 20 .…”
Section: Etiology and Risk Factors For Injurymentioning
confidence: 99%
“…Clinical signs include swelling, pain, crepitus, local tenderness, and warmth. Paratenonitis with tendinosis is defined as paratenon inflammation present in the setting of intratendinous degeneration, thought to be secondary to a failed healing response 29 . Histology shows the same findings as paratenonitis with additional loss of tendon collagen, fiber disorientation, and scattered vascular ingrowth.…”
Section: Etiology and Risk Factors For Injurymentioning
confidence: 99%
“…The term tendinopathy describes a range of clinical conditions related to tendons and surrounding structures [1, 2]. …”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the migration of immune cells, such as macrophages and mast cells, into adipose tissue is associated with a decrease in their circulating levels. As a consequence, the release of profibrotic factors, such as TGF-β, is reduced, and this may have a detrimental effect on tendon healing, especially if the production of type I and III collagen is also reduced [33][34][35] . As further consequence, the decreased availability of immune circulating cells should be responsible for less effective immune responses to acute tendon injury 36 .…”
Section: Pathogenetic Mechanismsmentioning
confidence: 99%