Inflammation in Wound Healing and Pathological Scarring

Hong, Yi-Kai; Chang, Yi-Han; Lin, Yuh Jyh; Chen, Brandon; Guevara, Bryan Edgar K; Hsu, Chao‐Kai

doi:10.1089/wound.2021.0161

Cited by 58 publications

(40 citation statements)

References 116 publications

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“…Therefore, the epidermal regeneration must first dissolve the scab, because the dryness of the scab is not conducive to the growth of bacteria; it has a certain protective effect on the wound. However, if the scab obstructs the drainage of exudate and makes the infection worse, it is not conducive to healing 20–23 …”

Section: Methodsmentioning

confidence: 99%

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Analysis of risk factors affecting wound healing and wound infection after meningioma resection

Wang,

Shou,

Gao

et al. 2024

International Wound Journal

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To analyse the risk factors affecting wound healing and infection after spinal meningioma resection surgery. The surgical incision healing of 137 patients who underwent spinal meningioma resection at our hospital from January 2021 to January 2024 was analysed. The data collected included physical examination findings, haematological and biochemical measurements, and various scales assessed upon admission and after surgery. These data were then analysed. The surgical wound healing, infection and postoperative complications were statistically analysed. Multiple logistic regression analysis method was used to conduct risk factor analysis on corresponding indicators; the odds ratio and p value of 95% confidence interval were calculated. Factors such as age and smoking history were significantly negatively correlated with wound healing after meningioma resection (odds ratio < 1.000, p < 0.05), while preoperative albumin and platelet count were significantly positively correlated with wound healing (odds ratio > 1.000, p < 0.05). Age, WHO Meningioma Grading, preoperative albumin and preoperative platelet were significantly negatively correlated with wound infection after meningioma resection (odds ratio < 1.000, p < 0.05). The history of virus infection and history of neurological disorders were significantly positively correlated with wound infection (odds ratio > 1.000, p < 0.05). The influence of each factor is different. Age, smoking history, WHO Meningioma Grading, preoperative albumin, preoperative platelets, history of virus infection and history of neurological disorders had the greatest influence on wound healing and infection after meningioma resection.

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Section: Methodsmentioning

confidence: 99%

“…However, if the scab obstructs the drainage of exudate and makes the infection worse, it is not conducive to healing. [20][21][22][23]…”

Section: Staging Of Surgical Wound Healingmentioning

confidence: 99%

Analysis of risk factors affecting wound healing and wound infection after meningioma resection

Wang,

Shou,

Gao

et al. 2024

International Wound Journal

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“…The second phase of wound healing, inflammation, is crucial for eliminating harmful bacteria and debris [48]. While inflammation is necessary for proper wound repair, it is important to control it through dressings [49].…”

Section: Inflammation Control Using Hydrogel Dressingsmentioning

confidence: 99%

Functional hydrogel dressings for wound management: a comprehensive review

Fu,

Zheng,

Wen

et al. 2023

Mater. Res. Express

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Hydrogels have gained significant attention as wound dressings due to their potential for rapid healing. Researchers have actively explored a range of techniques for antimicrobial applications, including incorporating drug payloads, utilizing inorganic nanometals, and harnessing the properties of natural cationic polymers. In terms of hemostasis and coagulation promotion, techniques such as drug delivery, adhesive physical hemostasis, and adhesive functional groups have been studied. To control inflammation, researchers have investigated the application of natural antioxidants and antioxidant functional groups, which have demonstrated anti-inflammatory effects. Furthermore, the smart responsiveness of hydrogel wound dressings to pH, temperature, and light has been explored. This review presents a summary of the research progress and application prospects in these areas and offers an outlook on the future development direction of hydrogel wound dressings.

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“…Monocytes migrate to the wound, differentiate into macrophages, phagocytose apoptotic cells and cellular debris, and trigger an inflammatory response [ 67 ]. Interestingly, CD4 + T cells were associated with wound healing, while CD8 + T cells negatively affected this process [ 68 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into the role of adipose-derived stem cells and secretome: potential biology and clinical applications in hypertrophic scarring

Wang,

Zhao,

et al. 2024

Stem Cell Res Ther

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Scar tissue is the inevitable result of repairing human skin after it has been subjected to external destructive stimuli. It leads to localized damage to the appearance of the skin, accompanied by symptoms such as itching and pain, which reduces the quality of life of the patient and causes serious medical burdens. With the continuous development of economy and society, there is an increasing demand for beauty. People are looking forward to a safer and more effective method to eliminate pathological scarring. In recent years, adipose-derived stem cells (ADSCs) have received increasing attention from researchers. It can effectively improve pathological scarring by mediating inflammation, regulating fibroblast proliferation and activation, and vascular reconstruction. This review focuses on the pathophysiological mechanisms of hypertrophic scarring, summarizing the therapeutic effects of in vitro, in vivo, and clinical studies on the therapeutic effects of ADSCs in the field of hypertrophic scarring prevention and treatment, the latest application techniques, such as cell-free therapies utilizing ADSCs, and discussing the advantages and limitations of ADSCs. Through this review, we hope to further understand the characterization of ADSC and clarify the effectiveness of its application in hypertrophic scarring treatment, so as to provide clinical guidance.

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Inflammation in Wound Healing and Pathological Scarring

Cited by 58 publications

References 116 publications

Analysis of risk factors affecting wound healing and wound infection after meningioma resection

Analysis of risk factors affecting wound healing and wound infection after meningioma resection

Functional hydrogel dressings for wound management: a comprehensive review

Insights into the role of adipose-derived stem cells and secretome: potential biology and clinical applications in hypertrophic scarring

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