Inflammation initiates cancer by depleting stem cells

Zajicek, G.

doi:10.1016/0306-9877(85)90026-x

Cited by 10 publications

(2 citation statements)

References 31 publications

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“…These findings may indicate that feline eyes containing a neoplasm are predisposed to trauma perhaps secondary to lack of sight in the affected eye, or self‐trauma due to inflammation induced by the neoplasm. These findings may also support the hypothesis that inflammation precedes the development of the neoplasm and may induce intraocular neoplastic transformation 6,18–20 . Although pleomorphic adenocarcinoma of the ciliary body in humans has been reported to occur in traumatized and inflamed human eyes, 21 traumatic lens ruptures were not detected in ciliary epithelial neoplasms in this study.…”

Section: Discussionsupporting

confidence: 87%

Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling

Grahn¹,

Peiffer

Cullen

et al. 2006

Veterinary Ophthalmology

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The objectives of this study were to evaluate morphologic, histochemical, and immunohistochemical characteristics of well-differentiated and anaplastic intraocular neoplasms of cats, and to develop a diagnostic algorithm for, and investigate the association of ruptured lenses with these neoplasms. Seventy-five feline globes with intraocular neoplasms were stained with hematoxylin and eosin and examined by light microscopy. Morphologic diagnoses included 33 intraocular sarcomas, 17 diffuse iris melanomas, 15 lymphosarcomas, three ciliary adenomas, one metastatic carcinoma, and six undifferentiated intraocular neoplasms. Sections of these globes were then stained with periodic acid Schiff (PAS), and immunohistochemical (IHC) labels for various cellular markers. Histochemical staining and IHC labeling confirmed cellular differentiation in 73/75 neoplasms but was discordant with morphologic diagnoses in 8/75. These included four neoplasms morphologically diagnosed as lymphosarcomas but which expressed differentiation antigens consistent with melanoma (n = 3) or ciliary adenocarcinoma (n = 1), and four tumors morphologically diagnosed as intraocular sarcomas that expressed differentiation antigens for melanoma (n = 2), metastatic carcinoma (n = 1), or remained undifferentiated (n = 1). Immunohistochemical labeling suggested a diagnosis in 5/6 morphologically undifferentiated neoplasms including one intraocular sarcoma, two diffuse iridal melanomas, and two ciliary adenocarcinomas. Based upon morphologic, histochemical, and IHC characterization, ruptured lens capsules were detected in 28/30 intraocular sarcomas, 3/24 diffuse iris melanomas and 1/11 lymphosarcomas, but not in ciliary epithelial neoplasms, metastatic carcinomas, or undifferentiated intraocular neoplasms. An algorithm is provided that facilitates stain and IHC label selection for differentiating anaplastic intraocular feline neoplasms.

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Section: Discussionsupporting

confidence: 87%

Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling

Grahn¹,

Peiffer

Cullen

et al. 2006

Veterinary Ophthalmology

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“…Associations between inflammation and tumourogenesis have not been as well defined; one theory hypothesises that neoplasia results from stem cell depletion, which can be caused by inflammation (Zajicek, 1985).…”

Section: Discussionmentioning

confidence: 99%

Primary ocular sarcomas in the cat

Peiffer

Monticello

Bouldin

1988

J of Small Animal Practice

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Primary ocular sarcomas were diagnosed following enucleation (1 2) or necropsy (one) in 13 cats over an eight year period. Twelve of the 13 cats were males; ages of affected animals were seven to 15 years, with a mean of 12. Five of the cats had a history of previous trauma and six others had a history of chronic uveitis. Morphologically the neoplasm was comprised of undifferentiated spindle cells and appeared to arise in the anterior uvea. The cancer was quite aggressive, with extension into adjacent tissues and/or distant metastases commonly encountered. Seven of 12 cats experienced confirmed tumour related deaths within months following enucleation and one was humanely destroyed at the time of original presentation.

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Ovarian Tumors, Stem Cells and Ontogeny: Imminentes Cognitiones

Schmidt¹

1989

Growth Factors and the Ovary

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Inflammation initiates cancer by depleting stem cells

Cited by 10 publications

References 31 publications

Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling

Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling

Primary ocular sarcomas in the cat

Ovarian Tumors, Stem Cells and Ontogeny: Imminentes Cognitiones

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