Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study

Sutkowy, Paweł; Lesiewska, Hanna; Woźniak, Alina; Malukiewicz, Grażyna

doi:10.3390/biomedicines11102607

Cited by 3 publications

(2 citation statements)

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“…Studies have investigated the association between systemic inflammatory markers and the risk of cataract development. Elevated levels of markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) have been implicated in the pathogenesis of cataracts ( 30 ). These inflammatory markers may contribute to lens opacification and the progression of cataracts.…”

Section: Discussionmentioning

confidence: 99%

“…Chronic inflammation is often accompanied by oxidative stress, and both processes have been related to cataract formation ( 31 ). Reactive oxygen species generated during inflammation may contribute to lens damage, accelerating the development of cataracts ( 30 ). Antioxidant mechanisms in the lens may become overwhelmed in the presence of chronic inflammation ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

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Association between dietary inflammation index and cataract: a population-based study from NHANES 2005–2008

Zhang,

Zhou,

Shen

et al. 2024

Front. Nutr.

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ImportanceVarious studies have widely explored the association between index of dietary inflammation (DII) and occurrence of diseases. Accumulating evidence have revealed that a lower DII seems to be protective against a variety of diseases. Nevertheless, the association between DII and age-related cataract remains unclear.ObjectiveTo investigate the correlation between DII and age-related cataract in a representative sample of the American population.Design, setting, and participantsThis cross-sectional population-based study comprised 6,395 participants from the National Health and Nutrition Examination Survey (NHANES) conducted in cycles from 2005 to 2008. DII was calculated using dietary recall information, with higher scores indicating greater inflammatory potential of the diet. Age-related cataract was evaluated using cataract surgery as a surrogate measure. Covariates included sociodemographic factors, lifestyle factors, physical measures, and comorbidities. Logistic regression models were employed to assess the association between DII and cataract. The presence of a non-linear relationship was examined using restricted cubic spline analysis. Subgroup analysis was conducted to explore potential interaction effects. Data analysis was performed from September 1 to December 30, 2022.Main outcomes and measuresAge-related cataract assessed through cataract surgery information obtained from a self-reported questionnaire.ResultsA total of 6,395 participants were included, with a mean (standard deviation, SD) age of 48.7 (15.3) years. Of these, 3,115 (48.7%) were male, 3,333 (52.1%) were non-Hispanic white, and 683 (10.7%) had cataract. The mean (SD) DII was −4.78 (1.74). After adjusting for all included covariates, DII showed a positive association with cataract, both as a continuous variable (odds ratio (OR): 1.054, 95% confidence interval (CI): 1.007–1.103, p = 0.023) and in quartiles, with the highest quartile compared to the lowest (OR: 1.555, 95% CI: 1.233–1.967, p < 0.001). Restricted cubic spline analysis revealed no evidence of a non-linear relationship (p for non-linearity 0.085). Subgroup analysis indicated no interaction effects among the studied covariates.Conclusions and relevanceThese findings suggest that a pro-inflammatory diet serves as a risk factor for the occurrence of cataracts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between dietary inflammation index and cataract: a population-based study from NHANES 2005–2008

Zhang,

Zhou,

Shen

et al. 2024

Front. Nutr.

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Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis

Li,

Gu,

et al. 2024

BMC Ophthalmol

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Background It is widely accepted that glaucoma-induced oxidative stress expedites cataracts’ process. Therefore, we examined the effects of apelin-13 against oxidative stress-induced damage in human lens epithelial cells (HLECs) and investigated the potential pathogenic mechanism of acute primary angle-closure glaucoma. Methods This experiment included five groups: control, H 2 O 2 , apelin-13 + H 2 O 2 , ML221 + H 2 O 2 , and apelin-13 + ML221 + H 2 O 2 . ML221 was employed in rescue experiments as an APJ antagonist. HLECs were pretreated with or without apelin-13 and subsequently exposed to H 2 O 2 . HLECs’ viability was assessed by CCK8. Cell apoptosis was determined using Annexin V-FITC/PI staining. The mitochondrial membrane potential was assessed by fluorescent probe JC-1. Intracellular G6PD activity, NADPH/NADP+, and GSH/GSSG ratios were detected to assess the cells’ oxidative damage. Result Apelin-13 reversed the H 2 O 2 -induced decrease in cell viability. The increased expression of G6PD and GLTU1, the G6PD, GSH/GSSG and NADPH/NADP + levels showed that apelin-13 can mitigate the H 2 O 2 -induced inhibition of the pentose phosphate pathway and dysregulation of cell redox status in the apelin-13 + H 2 O 2 group compared with the H 2 O 2 group. In H 2 O 2 -treated HLECs, apelin-13 can mitigate cell apoptosis, promote Bcl-2 expression, and suppress the Bax and Caspase-3 expression. In addition, H 2 O 2 substantially reduced the mitochondrial membrane potential in HLECs, which was reversed by apelin-13. Notably, the inhibition of APJ intensified oxidative damage in H 2 O 2 -induced HLECs, demonstrating that the effects of apelin-13 were hindered by ML221. Conclutions Apelin-13 reduced oxidative damage and apoptosis in HLECs through APJ. These results demonstrate that apelin-13 can be employed as a potential drug for glaucoma with cataracts to delay the progression of cataracts. Supplementary Information The online version contains supplementary material available at 10.1186/s12886-024-03746-6.

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Association between systemic immune-inflammation index and cataract among outpatient US adults

Huang,

Wu,

et al. 2024

Front. Med.

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BackgroundWhile several studies have noted a higher SII correlates with multiple diseases, research on the association between SII and cataract remains limited. Our cross-sectional study seeks to examine the association between SII and cataract among outpatient US adults.MethodsThis compensatory cross-sectional study utilized NHANES data from 1999 to 2008 cycles, conducting sample-weighted multivariate logistic regression and stratified analysis of subgroups.ResultsAmong 11,205 adults included in this study (5,571 [46.2%] male; 5,634 [53.8%] female), 2,131 (15.2%) had cataract and 9,074 (84.8%) did not have cataract. A fully adjusted model showed that SII higher than 500 × 109/L was positively correlated with an increased risk of cataracts among women (OR, 1.27; 95% CI, 1.02–1.59) (p = 0.036). However, no difference was found in the men subgroup, and there was no significant interaction between SII and sex.ConclusionOur results indicated that a SII higher than 500 × 109/L was positively correlated with an increased risk of cataracts in women. This study is the first to specifically investigate the impact of a high SII on cataract risk in outpatient adults in the United States. By effectively addressing inflammation, it is possible to mitigate cataract progression and significantly enhance patient outcomes.

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Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study

Cited by 3 publications

References 52 publications

Association between dietary inflammation index and cataract: a population-based study from NHANES 2005–2008

Association between dietary inflammation index and cataract: a population-based study from NHANES 2005–2008

Protective effect of apelin-13 in lens epithelial cells via inhibiting oxidative stress-induced apoptosis

Association between systemic immune-inflammation index and cataract among outpatient US adults

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