Inflammation is correlated with severity and outcome of cerebral venous thrombosis

Wang, Liyan; Duan, Jiangang; Bian, Tingting; Wang, Mengqi; Wu, Longfei; Zhang, Zhen; Zhang, Xuxiang; Wang, Chunxiu; Ji, Xunming

doi:10.1186/s12974-018-1369-0

Cited by 50 publications

(75 citation statements)

References 33 publications

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“…CVT is an uncommon condition with an incidence of 1.3-1.6/100,000 in Western countries (10). Traditionally, the most prevalent aetiology of CVT was infections but nowadays aseptic CVT are more frequent.…”

Section: Case Reportmentioning

confidence: 99%

Torcular herophili and lateral sinus thrombosis: An atypical presentation of Lemièrre's syndrome

Baltasar-Corral

Martín‐Rojas

Parra-Virto

et al. 2019

IRDR

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Lemièrre's syndrome (LS) is an uncommon disease characterized by septic thrombophlebitis of the jugular vein in the context of otorhinolaryngologic infections. These patients are often young and the pharyngotonsillar infection is the most frequent primary focus, but other foci like acute otitis media or otomastoiditis have been described. Although the internal jugular vein is the most commonly affected site, a few case reports have been published with thrombosis of other veins, such as the facial vein or transverse sinus. We report the case of a 93-year-old woman with an atypical presentation of LS presenting with thrombophlebitis of the internal jugular vein, transverse sinuses and Herophili torcula after an acute otitis media complicated with acute otomastoiditis. Infectious cerebral venous thrombosis (CVT) is rare and accounts for 6-12% of the total in large adult series and is usually associated to otorhinolaryngologic infections. CVT is an atypical presentation of LS that can be potentially lethal, especially during the acute phase. For this reason, clinical suspicion and early treatment are vital to improve the prognosis of these patients. Although surgical treatment is recommended in cases of LS complicated with CVT, conservative management with antibiotics and anticoagulation lead to ad integrum restitutio without neurological sequelae in our case, suggesting that surgical treatment may not be necessary in all cases of LS complicated with CVT.

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Section: Case Reportmentioning

confidence: 99%

Torcular herophili and lateral sinus thrombosis: An atypical presentation of Lemièrre's syndrome

Baltasar-Corral

Martín‐Rojas

Parra-Virto

et al. 2019

IRDR

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“…Recently it is regarded that immune and coagulation systems are functionally connected [5,6]. Proin ammatory cytokines and other mediators have been described to be responsible for activating the coagulation system as well as down-regulating important physiologic anticoagulant pathways [7][8][9][10]. A previous study revealed that IL-6 could mediate thrombocytosis, platelet hyperreactivity, and accelerate extra-intestinal thrombosis associated with experimental colitis [11].…”

Section: Introductionmentioning

confidence: 99%

Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis

et al. 2020

Preprint

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Objective: This study aimed to assess the role of coagulation-related indicators such as plasma ﬁbrinogen (FIB), D-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) and their association with disease activity.Methods: Data from 105 RA patients and 102 age- and gender- matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide the RA patients into inactive group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). The association between plasma FIB, D-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Receiver operating characteristic (ROC) curve was applied to determine the area under curve (AUC) value. The prognostic value of plasma FIB, D-dimer, and FDP in the RA disease activity was tested by logistical regression analysis.Results: RA patients showed higher FAR levels of plasma FIB, D-dimer, and FDP than the controls (P < 0.01). Plasma FIB, D-dimer, and FDP were also increased in active group of RA patients than those in inactive group (P < 0.001). Spearman analysis showed that plasma FIB, D-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. ROC curve analyses revealed that the AUC of D-dimer was higher than ESR and RF, and that of FDP was higher than RF in RA patients. In addition, the optimal cut-oﬀ value of plasma FIB, D-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Logistical regression analyses showed that D-dimer (odds ratio = 2.862, 95% conﬁdence interval: 1.851-4.426, P < 0.001) was a predictor for RA disease activity.Conclusions: FIB, D-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. D-dimer may act as a novel inﬂammatory parameter for predicting disease activity in RA patients.

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“…We also found that a high level of HBs-Ab in all CVT patients, but there was no signi cant difference between the headache and non-headache groups. Previous studies reported that CVT patients had a higher HBs-Ag-positive rate compared to health controls 15,17 , indicating HBV infection may be a risk factor for CVT 17 .…”

Section: Discussionmentioning

confidence: 93%

“…Infection has been considered as one of the most common causes of CVT 15 and the neutrophil-tolymphocyte ratio is signi cantly associated with poor outcomes at discharge 15,16 . Our study showed that head and face infection or upper respiratory infection occurred in 27.68% (26/69) of the patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of cerebral venous sinus thrombosis patients with new-onset of headache

Wang

Fang

2020

Preprint

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Objective : This study aimed to assess the clinical characteristics of cerebral venous sinus thrombosis (CVT) patients with new-onset headache and to identify the risk factors for headache in this population.Methods : We retrospectively reviewed the demographic and clinical data of 69 CVT patients recruited between September 2017 and September 2019. Patients were classified into two groups, the headache group and the non-headache group, according to the presence or absence of new-onset headache symptoms at admission. The following characteristics and parameters were measured and analyzed, including gender, age, Diseased sinus amount(DSA), and so on.Results : The incidence of headache was 75% in this cohort. The proportion of female patients in the headache group was higher than that in the non-headache group. Patients in the headache group were younger than those without headache. CVT patients of headache group showed higher LR, BUN, and (ICP)compared to the non-headache group, whereas MCV and levels of protein (CSF) and LDH (CSF) were lower in headache patients. The data also revealed younger age and the increased level of chloride ion CL - (CSF) were the risk factors for the occurrence of headache in CVT patients.Conclusions: The age, LR, MCV, BUN levels, ICP, protein (CSF), and LDH (CSF) in patients with headache were significantly different from those in the non-headache group at admission. Younger age and a level of CL - (CSF) were risk factors for headache in CVT patients. These findings may provide guidance for clinical diagnosis and treatment of CVT.

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Inflammation is correlated with severity and outcome of cerebral venous thrombosis

Cited by 50 publications

References 33 publications

Torcular herophili and lateral sinus thrombosis: An atypical presentation of Lemièrre's syndrome

Torcular herophili and lateral sinus thrombosis: An atypical presentation of Lemièrre's syndrome

Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis

Clinical characteristics of cerebral venous sinus thrombosis patients with new-onset of headache

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