2018
DOI: 10.1016/j.intimp.2017.10.019
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Inflammation is regulated by the adenosine derivative molecule, IFC-305, during reversion of cirrhosis in a CCl4 rat model

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Cited by 16 publications
(9 citation statements)
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“…It is known that the extracellular ATP triggers NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, which could lead to the generation of a series of inflammatory cytokines, such as cleaved caspase-1, interleukin (IL)-1β, IL-18, IL-6 and tumor necrosis factor-α (TNF-α) (16,17). Meanwhile, adenosine was reported to be anti-inflammatory, immunosuppressive and have protective effects in sepsis-associated organ injury (18,19). Therefore, CD39 plays a suppressive role in the NLRP3 inflammasome activation and its mediated downstream pro-inflammatory cytokines.…”
Section: Introductionmentioning
confidence: 99%
“…It is known that the extracellular ATP triggers NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, which could lead to the generation of a series of inflammatory cytokines, such as cleaved caspase-1, interleukin (IL)-1β, IL-18, IL-6 and tumor necrosis factor-α (TNF-α) (16,17). Meanwhile, adenosine was reported to be anti-inflammatory, immunosuppressive and have protective effects in sepsis-associated organ injury (18,19). Therefore, CD39 plays a suppressive role in the NLRP3 inflammasome activation and its mediated downstream pro-inflammatory cytokines.…”
Section: Introductionmentioning
confidence: 99%
“…The anti-inflammatory role of IFC-305 was also supported by elevation of IL-10, an enhanced metabolic activity of arginase, reduction of NO levels in serum rats, a diminution of the protein levels of inducible nitric oxide synthetase, and an increment of the protein levels of arginase 1 in the liver. These results suggest that the IFC-305 modulates the immune response in cirrhosis and supports the hepatic protective action through an antiinflammatory role, mainly mediated by Kupffer cells [64].…”
Section: Inflammation the Beginning Of Liver Disease And A Key Of Ifmentioning
confidence: 52%
“…In contrast, the promoter of Col1a1 gene is hypomethylated in cirrhosis but gains DNA methylation upon treatment with IFC-305, correlating with a decrease of Col1a1 transcript and protein level, showing that the treatment restores globally and specifically epigenetic modifications [30]. The microarray analysis also showed modification of immunity genes which where explored in the CCl 4 model; it was found that the IFC-305 compound reduced inflammatory cytokines and increased the anti-inflammatory ones like IL-10, supporting the modulation of the macrophage phenotypes M1 and M2 [31].…”
Section: Introductionmentioning
confidence: 76%