Inflammation levels in patients with alcohol and substance use disorders

Kulu, Müberra; Özsoy, Filiz; Demir, Bahadır

doi:10.17826/cumj.975848

Cited by 5 publications

(9 citation statements)

References 32 publications

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“…Sentetik kannabinoid kullanımı olan hastalar ile yürütülen bir çalışmada MPV değerleri sağlıklı kontrollerden yüksek hesap edilmiştir (26). Esrar ve sentetik kannabinoid kullanım bozukluğu olan hastalarda yapılan bir çalışmada ise MPV değerleri kontrollerden yüksek bulunmuştur (30). OpKB hastaları ile yapılan başka bir çalışmada ise; MPV değerleri kontrollerden farklı bulunmamıştır (19).…”

Section: Discussionunclassified

Opiyat Kullanım Bozukluğu Hastalarında İnflamasyon: Nötrofil/Lenfosit, Monosit/Lenfosit, Trombosit/Lenfosit, Monosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Kulu¹,

Özsoy

Demir

2023

Bağımlılık Dergisi

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Amaç: Bu çalışmada; Opiyat Kullanım Bozukluğu (OpKB) tanılı hastaların nötrofil/lenfosit (NLO), platelet/lenfosit (PLO), monosit/lenfosit (PLO) oranı gibi periferik inflamasyon belirteçlerini kontroller ile karşılaştırarak retrospektif incelemeyi amaçladık. Yöntem: Çalışmaya; 201 kişi (101 kişi OpKB ve 100 kontrol) alındı. Tüm katılımcıların yaş, cinsiyet gibi demografik verilerini içeren demografik veri formu oluşturuldu. Sonrasında tam kan sayımı ile değerlendirilen laboratuvar parametreleri incelendi. Bulgular: Tüm katılımcılar erkek ve yaş ortalaması 30,68±10,60 idi. Hasta grubunun hemoglobin değeri 14,78±1,29, hematokrit değeri 44,02±3,70 olarak hesap edildi. Yine hastalarda eritrosit 5,00±0,39 ve RDW-SD 43,90±4,26 ile sağlıklı kontrollerden yüksekti. NLO, MLO ve PLO değerleri hasta grubunda sağlıklı kontrollere göre düşük olarak hesap edildi. Sonuç: OpKB hastalarında bazı inflamatuvar parametrelerinde değişiklikler olduğu gösterilmiştir. İnflamatuvar parametrelerindeki bu değişikliklere bağlı oluşabilecek komplikasyonlar; hem tedavi planı hem hastanın semptomlarının değerlendirilmesinde dikkate alınmalıdır.

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Section: Discussionunclassified

Opiyat Kullanım Bozukluğu Hastalarında İnflamasyon: Nötrofil/Lenfosit, Monosit/Lenfosit, Trombosit/Lenfosit, Monosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Kulu¹,

Özsoy

Demir

2023

Bağımlılık Dergisi

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“…Patients with opiate use disorder showed lower NLR, MLR and PLR values 26,27 . Moreover, alcohol and synthetic cannabinoid use were associated with reduced NLR 28 . The immune system alteration is also shown in patients with substance use disorder including methamphetamine use disorder 29,30 .…”

Section: Introductionmentioning

confidence: 99%

“… 26 , 27 Moreover, alcohol and synthetic cannabinoid use were associated with reduced NLR. 28 The immune system alteration is also shown in patients with substance use disorder including methamphetamine use disorder. 29 , 30 Investigation of these markers in methamphetamine use disorder is rare, 30 and there is no previous study detecting these markers in patients with methamphetamine‐induced psychotic disorder.…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte‐related ratios in methamphetamine‐induced psychotic disorder in Taiwan, comparing with patients with schizophrenia

Ng,

Lu,

Chen

et al. 2024

Addiction Biology

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The lymphocyte‐related ratios, neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte ratio (MLR) and platelet‐to‐lymphocyte ratio (PLR) are new measures of inflammation within the body. Few studies have investigated the inflammatory response of patients with methamphetamine‐induced psychotic disorder. Clinically, the psychotic symptoms and behavioural manifestation of methamphetamine‐induced psychotic disorder are often indistinguishable from paranoid schizophrenia. We aimed to determine the differences in these inflammatory markers between patients with methamphetamine‐induced psychotic disorder, patients with schizophrenia and healthy individuals. A total of 905 individuals were recruited. The NLR and MLR were found to be higher in both patients with methamphetamine‐induced psychotic disorders and patients with schizophrenia compared with healthy controls. There was no significant difference between the three groups in PLR. When compared with the control group, the methamphetamine‐induced psychotic disorder group was significantly higher in NLR 27% (95%CI = 11 to 46%, p = 0.001), MLR 16% (95%CI = 3% to 31%, p = 0.013) and PLR 16% (95%CI = 5% to 28%, p = 0.005). NLR of the group with methamphetamine‐induced psychotic disorder was 17% (95%CI = 73% to 94%, p = 0.004) less than the group with schizophrenia, while MLR and PLR did not differ significantly between the two groups. This is the first study that investigated the lymphocyte‐related ratios in methamphetamine‐induced psychotic disorder when compared with patients with schizophrenia and healthy individuals. The results showed that both patients with methamphetamine‐induced psychotic disorder and patients with schizophrenia had stronger inflammatory responses than the healthy control. Our finding also indicated that the inflammatory response of methamphetamine‐induced psychotic disorder was between those of patients with schizophrenia and healthy individuals.

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“…However, abnormal responses or chronic inflammation may be pathological [ 8 ]. The inflammatory mediators are linked to many psychiatric disorders and contribute to neuroinflammation [ 3 , 7 - 9 ].…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

Gürbüzer,

Güler,

Tör

2024

Psychiatry Investig

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Objective Methamphetamine use disorder (MUD) is a global health condition that impairs a person’s health which may result in morbidity and mortality. Inflammation is a crucial process playing a vital role in MUD. For this reason, it is necessary to examine biochemical parameters for follow-up and treatment alternatives.Methods We aimed to reveal the relationship between inflammatory response and MUD by evaluating peripheral hemogram parameters, leukocyte count, subtypes, and their ratios to each other, systemic immune inflammation index (SII), monocyte/high-density lipoprotein (HDL) ratio, and human C-reactive protein (CRP) in adult men with MUD. We included 76 adult male participants in the patient group and 70 adult male participants in the control group. We calculated the neutrophil/lymphocyte rate (NLR), monocyte/lymphocyte rate (MLR), platelet/lymphocyte rate (PLR), and basophil/lymphocyte rate (BLR). In addition, we obtained the SII and the monocyte/HDL rate.Results The patients’ leukocyte (p<0.001), platelet (p<0.001), plateletcrit (PCT) (p=0.002), neutrophil (p<0.001), monocyte (p=0.002), CRP (p<0.001), NLR (p=0.001), PLR (p=0.004), MLR (p=0.009), SII (p<0.001) and monocyte/HDL ratio (p<0.001) were higher than the control group. We observed a significant and positive relationship between the daily methamphetamine intake, and methamphetamine use duration (p=0.002), PCT (p=0.044), neutrophil (p=0.021), NLR (p=0.001), PLR (p=0.004), MLR (p=0.029), and SII (p<0.001). Daily methamphetamine intake had a significant and positive effect on SII. A one-unit increase in daily methamphetamine intake elevated SII by 165.53 units.Conclusion The results confirm the presence of peripheral subclinical inflammation and systemic immune inflammation in adult men with MUD.

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Inflammation levels in patients with alcohol and substance use disorders

Cited by 5 publications

References 32 publications

Opiyat Kullanım Bozukluğu Hastalarında İnflamasyon: Nötrofil/Lenfosit, Monosit/Lenfosit, Trombosit/Lenfosit, Monosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Opiyat Kullanım Bozukluğu Hastalarında İnflamasyon: Nötrofil/Lenfosit, Monosit/Lenfosit, Trombosit/Lenfosit, Monosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi

Lymphocyte‐related ratios in methamphetamine‐induced psychotic disorder in Taiwan, comparing with patients with schizophrenia

Methamphetamine Use Disorder and Inflammation: A Case-Control Study

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