Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

Kacířová, Miroslava; Zmeškalová, Anna; Kořínková, Lucia; Železná, Blanka; Kuneš, Jaroslav; Maletı́nská, Lenka

doi:10.1042/cs20191313

Cited by 40 publications

(32 citation statements)

References 265 publications

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“…A chronic low-grade inflammation, triggered by nutrient surplus, is a constituent of obesity. Adipose-originated metabolic inflammation develops pari passu with insulin resistance and, as such, is a key element in the metabolic syndrome [ 14 ]. In this study, we found there were no significant differences in serum IL-6, TNF-α, LBP and leptin between MHO and MUO subjects.…”

Section: Discussionmentioning

confidence: 99%

The role of the gut microbiota on the metabolic status of obese children

et al. 2021

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Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator. Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5–15 years) were divided into three groups: metabolically healthy obese (MHO, n = 42), metabolic unhealthy obese (MUO, n = 23), and healthy normal weight controls (Con, n = 21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO group, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, LBP was positively correlated with genus Roseburia and Faecalibacterium, and negatively correlated with genus Lactobacillus, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p < 0.05). Conclusion Although there are distinct differences in the characteristic gut microbiota of the MUO population versus MHO, dysbiosis of gut microsystem is already extant in the MHO cohort. The abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds, suggesting that dysbiosis of gut microbiota, present in the MHO children, conceivably serves as a compensatory or remedial response to a surfeit of nutrients.

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Section: Discussionmentioning

confidence: 99%

The role of the gut microbiota on the metabolic status of obese children

et al. 2021

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“…A chronic low-grade in ammation, triggered by nutrient surplus, is a constituent of obesity. Adiposeoriginated metabolic in ammation develops pari passu with insulin resistance and, as such, is a key element in the metabolic syndrome [12]. In this study, we found there were no signi cant differences in serum IL-6, TNF-α and leptin between MHO and MUO subjects.…”

Section: Discussionmentioning

confidence: 40%

Metabolically Healthy Obese Children and the Role of the Gut Microbiota

Chen¹,

McCormick²,

Zhang³

et al. 2020

Preprint

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Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic status, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6 and TNF-α, and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided into three groups: metabolically healthy obese (MHO, n=42), metabolic unhealthy obesity (MUO, n=23), and healthy normal weight controls (Con, n=21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO subgroup, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p<0.05).Conclusion Dysbiosis of gut microsystem prevails in the MHO cohort, and the abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds. As for a role in the etiology or facilitation of obesity- or perhaps vice versa- this childhood microbial imbalance awaits long-term, longitudinal investigation.

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“…A chronic low-grade in ammation, triggered by nutrient surplus, is a constituent of obesity. Adiposeoriginated metabolic in ammation develops pari passu with insulin resistance and, as such, is a key element in the metabolic syndrome [14]. In this study, we found there were no signi cant differences in serum IL-6, TNF-α, LBP and leptin between MHO and MUO subjects.…”

Section: Discussionmentioning

confidence: 41%

The Role of the Gut Microbiota on the Metabolic Status of Obese Children

Yuan

Chen

McCormick

et al. 2021

Preprint

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Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided into three groups: metabolically healthy obese (MHO, n=42), metabolic unhealthy obese (MUO, n=23), and healthy normal weight controls (Con, n=21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO group, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, LBP was positively correlated with genus Roseburia and Faecalibacterium, and negatively correlated with genus Lactobacillus, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p<0.05).Conclusion Although there are distinct differences in the characteristic gut microbiota of the MUO population versus MHO, dysbiosis of gut microsystem is already extant in the MHO cohort. The abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds, suggesting that dysbiosis of gut microbiota, present in the MHO children, conceivably serves as a compensatory or remedial response to a surfeit of nutrients.

show abstract

Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?

Cited by 40 publications

References 265 publications

The role of the gut microbiota on the metabolic status of obese children

The role of the gut microbiota on the metabolic status of obese children

Metabolically Healthy Obese Children and the Role of the Gut Microbiota

The Role of the Gut Microbiota on the Metabolic Status of Obese Children

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