Inflammation mechanism and anti-inflammatory therapy of dry eye

Chu, Liyuan; Wang, Caiming; Zhou, Hongyan

doi:10.3389/fmed.2024.1307682

Cited by 4 publications

(1 citation statement)

References 147 publications

(150 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-KB (NF-KB), which follow ROS-induced lipid peroxidation and occur in response to cellular stresses, leads to the production of matrix metalloproteinases (MMPs) and cytokines such as tumor necrosis factor (TNF-α), interleukin (IL)-1α, IL-1β, and MMP-9 [16,47]. In ocular tissues, this inflammatory setting induces the maturation of antigen-presenting cells (APCs) with the release of additional proinflammatory cytokines, causing epithelial cell damage [48]. Furthermore, activated APCs induce an adaptive immune response, rendering inflammation in DED more susceptible to exacerbation [11].…”

Section: Relationship Between Oxidative Stress and Dedmentioning

confidence: 99%

Potential New Target for Dry Eye Disease—Oxidative Stress

Bu,

Liu,

Zhang

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It is characterized by loss of tear film homeostasis and accompanied by ocular symptoms that may potentially result in damage to the ocular surface and even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, and lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, and ethanol consumption. As its prevalence continues to rise, DED has garnered considerable attention, prompting the exploration of potential new therapeutic targets. Recent studies have found that when the production of ROS exceeds the capacity of the antioxidant defense system on the ocular surface, oxidative stress ensues, leading to cellular apoptosis and further oxidative damage. These events can exacerbate inflammation and cellular stress responses, further increasing ROS levels and promoting a vicious cycle of oxidative stress in DED. Therefore, given the central role of reactive oxygen species in the vicious cycle of inflammation in DED, strategies involving antioxidants have emerged as a novel approach for its treatment. This review aims to enhance our understanding of the intricate relationship between oxidative stress and DED, thereby providing directions to explore innovative therapeutic approaches for this complex ocular disorder.

show abstract

Section: Relationship Between Oxidative Stress and Dedmentioning

confidence: 99%

Potential New Target for Dry Eye Disease—Oxidative Stress

Bu,

Liu,

Zhang

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

Low friction hydrogel with diclofenac eluting ability for dry eye therapeutic contact lenses

Silva,

Oliveira,

Marto-Costa

et al. 2025

Methods

View full text Add to dashboard Cite

Investigating Risk Factors for Meibomian Gland Dysfunction and Loss Among Young Medical Trainees

Farid,

Kim,

Spina

et al. 2024

Cornea

View full text Add to dashboard Cite

Purpose: To determine risk factors for meibomian gland disease and associated structural abnormalities in meibography among young medical trainees. Methods: This study included 84 medical students and residents younger than 45 years. All participants completed an ocular history and lifestyle questionnaire and the standardized patient evaluation of eye dryness (SPEED) II questionnaire. Meibomian gland (MG) dropout and structural changes were evaluated using meibography and scored by 2 graders using meiboscores. Statistical analysis aimed to identify MG loss risk factors. Results: Eighty-four individuals participated, and 168 meibography images were reviewed. Previous contact lens (CL) use (n = 88) demonstrated increased MG loss (P = 0.007). Correlation analysis revealed positive associations between MG loss and both frequency (Spearman r = 0.212, P = 0.003) and duration (Spearman r = 0.271, P <0.001) of CL use. Eye makeup users (n = 112) showed greater MG loss than nonusers (n = 56, P = 0.030), particularly eyeliner (n = 102) and eyeshadow (n = 100) users showing increased meiboscores (P = 0.020 and P = 0.040, respectively). Self-reported screen time and SPEED II scores did not correlate with meiboscores (P >0.05). Conclusions: In a young trainee population, where age-related factors are reduced, previous CL use and eye makeup use are significant risk factors for MG loss. Frequency and length of CL wear affect MG dropout severity. Eye makeup usage also affected MG loss. Highlighting the incongruence of symptoms to signs, SPEED II scores showed no relationship with MG structural integrity.

show abstract

Inflammation mechanism and anti-inflammatory therapy of dry eye

Cited by 4 publications

References 147 publications

Potential New Target for Dry Eye Disease—Oxidative Stress

Potential New Target for Dry Eye Disease—Oxidative Stress

Low friction hydrogel with diclofenac eluting ability for dry eye therapeutic contact lenses

Investigating Risk Factors for Meibomian Gland Dysfunction and Loss Among Young Medical Trainees

Contact Info

Product

Resources

About