Inflammation of the Prostate Gland

Moore, Robert A.

doi:10.1016/s0022-5347(17)71941-6

“…CP and benign prostatic hyperplasia (BPH) are understood to affect younger and older men, respectively, but demographic studies show overlap in symptoms and age groups. Roberts et al [2] found a prevalence of 6.3% histologic inflammation of the prostate in a report on autopsy studies [3], whereas in another series [4] prevalence reached 44%. During the time period studied by Collins et al [1], CP or BPH were diagnosed in 5.6 million annual physician visits, with more than 17% diagnoses of concomitant CP and BPH in these patients.…”

Section: Epidemiologymentioning

confidence: 91%

Update on minimally invasive therapy for chronic prostatitis/chronic pelvic pain syndrome

Kastner

¹

2008

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Once primary treatment fails, the diverse causes and symptoms of chronic pelvic pain syndrome require clinicians to consider several secondary approaches. Multimodal therapy addresses unique symptoms and targets illness origin. However, once medical modalities fail, minimally invasive therapies should be considered, including transurethral needle ablation hyperthermia, cooled thermotherapy, electromagnetic chair, prostatic massage, and intraprostatic botulinum toxin A injection. Low evidence levels exist for all approaches, but we anticipate promising results of larger trials for cooled thermotherapy and look forward to the emergence of experimental techniques using botulinum toxin A.

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“…Chronic prostatitis is more prevalent than commonly thought. Roberts et al [ 2 ] found a prevalence of 6.3% histologic infl ammation of the prostate in a report on autopsy studies [ 3 ], whereas in another series [ 4 ] prevalence reached 44%.…”

Section: Epidemiologymentioning

confidence: 92%

Update on minimally invasive therapy for chronic prostatitis/chronic pelvic pain syndrome

Kastner

¹

2008

Curr Urol Rep

5

0

View full text Add to dashboard Cite

Once primary treatment fails, the diverse causes and symptoms of chronic pelvic pain syndrome require clinicians to consider several secondary approaches. Multimodal therapy addresses unique symptoms and targets illness origin. However, once medical modalities fail, minimally invasive therapies should be considered, including transurethral needle ablation hyperthermia, cooled thermotherapy, electromagnetic chair, prostatic massage, and intraprostatic botulinum toxin A injection. Low evidence levels exist for all approaches, but we anticipate promising results of larger trials for cooled thermotherapy and look forward to the emergence of experimental techniques using botulinum toxin A.

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“…From as early as 1937, inflammation has been implicated in the pathogenesis of BPH [62], and there is substantial new data reinforcing this with roles for macrophages, T and B lymphocytes, as well as various inflammatory cytokines and chemokines [61,63,64]. Similarly, chronic inflammation has long been associated with carcinogenesis in various tissues, and emerging evidence supports a role for inflammation in prostate cancer development as well as progression and metastasis [65,66].…”

Section: Essential Immune Contribution In Prostate Diseasementioning

confidence: 98%