Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

Lanza, Gaetano Antonio; Barone, Lucy; Scalone, Giancarla; Pitocco, Dario; Sgueglia, Gregory A.; Mollo, Roberto; Nerla, Roberto; Zaccardi, Francesco; Ghirlanda, Giovanni; Crea, Filippo

doi:10.1111/j.1365-2796.2010.02285.x

Cited by 33 publications

(45 citation statements)

References 42 publications

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“…Abnormalities in arterial function and low-density lipoprotein oxidation may persist for several weeks after intramuscular injection of an influenza vaccine, which may, in part, be associated with the earlier reported increase in cardiovascular risk during the first weeks postvaccination [24]. Overall, influenza vaccination by intramuscular injection triggers a mild, but measurable inflammatory response in humans that persists systemically for weeks [24,25] with both known and unknown consequences (TABLE 1) [3,4,24,[34][35][36].…”

Section: Influenza Vaccinementioning

confidence: 97%

“…The concomitant changes of CRP levels and heart rate variability parameters following intramuscular injection of an influenza vaccine suggest a pathophysiological link between impaired cardiac parasympathetic function and a vaccinationinduced subclinical inflammatory state, which may transiently increase the risk of cardiovascular events [3].…”

Section: Biomarkers For Measuring the Degree Of Systemic Inflammationmentioning

confidence: 99%

“…Vaccination by intramuscular injection of an immunostimulating vaccine-adjuvant complex as commonly practiced represents a 'double-edged sword,' with its disease-fighting power accompanied by adverse side effects (TABLES 1 & 2), which range from local and systemic inflammatory responses, fever, platelet activation, cardiac autonomic dysfunction and flu-like symptoms [2][3][4][5] to severe pain (induced by injection of certain vaccines) [6][7][8]. Even though most of the side effects induced by licensed vaccines are seemingly local with short duration, WHO and its Global Advisory Committee on Vaccine Safety warned that contemporary preclinical and clinical trials could identify only a subset of the vaccinationinduced adverse events [9].…”

Section: Abstract: Inflammation • Injectable Vaccine • Innate Immunitmentioning

confidence: 99%

“…Even though vaccination-induced systemic inflammation is usually transient (i.e., a few weeks [24,25]), it is associated with a temporary deterioration in cardiac autonomic nervous system function among healthy human subjects following immunization with an injectable influenza vaccine [3,4,31]. Influenza vaccination is also associated with a small but significantly increased risk for Guillain-Barré syndrome [32].…”

Section: Influenza Vaccinementioning

confidence: 99%

“…To confirm whether vaccination-induced acute inflammation [2][3][4] could evolve into chronic low-grade inflammation and trigger any of these ailments in a subset of vaccinees over time [15] is of paramount importance to public health. Since the concept of vaccine safety is evolving from 'protection against pathogeninduced diseases' to 'no possibility of inducing adverse consequences,' public demands for better understanding of vaccination-induced inflammation and a resolution of its adverse effects have to be rigorously addressed.…”

Section: Abstract: Inflammation • Injectable Vaccine • Innate Immunitmentioning

confidence: 99%

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The Yin–Yang arms of vaccines: disease-fighting power versus tissue-destructive inflammation

Tang¹,

Nguyen

2014

Expert Review of Vaccines

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The disease-fighting power of vaccines has defeated many pathogens and has been credited with global reduction of mortality and morbidity. However, most vaccine developments focus on the enhancement of effector responses with systemic inflammation and the consequences overlooked. Recent evidence shows that systemic inflammatory phenotypes, acute or chronic, are both detrimental and should be avoided if possible. Since noninvasive vaccination by painless delivery of nasal vaccines and skin patch vaccines could elicit potent protective immunity without inducing systemic inflammation, it can be predicted that vaccinology will increasingly see the abandonment of the 'needle-injection' paradigm for vaccine development. The findings that specific viral particles could rapidly remodel the tissue environment postinfection in favor of some pathogens with the capacity to suppress others illustrate the pressing need for a deeper understanding of the underlying mechanisms in order to unlock the full potential of immunological intervention.

show abstract

Section: Influenza Vaccinementioning

confidence: 97%

Section: Biomarkers For Measuring the Degree Of Systemic Inflammationmentioning

confidence: 99%

Section: Abstract: Inflammation • Injectable Vaccine • Innate Immunitmentioning

confidence: 99%

Section: Influenza Vaccinementioning

confidence: 99%

Section: Abstract: Inflammation • Injectable Vaccine • Innate Immunitmentioning

confidence: 99%

See 3 more Smart Citations

The Yin–Yang arms of vaccines: disease-fighting power versus tissue-destructive inflammation

Tang¹,

Nguyen

2014

Expert Review of Vaccines

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Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Khatami

2020

Clinical & Translational Med

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Schematic representation of cause, exacerbation and consequence of vaccinesinduced diverse immune disorders in immune-responsive or immune-privileged tissues. It depicts that vaccination of the unborn, alter biology of trophoblastembryo-fetus-placenta and orderly growth and development affecting epithelialmesenchymal transition, proper expression of constituent-inducible receptor molecules; consequently influence immunity of newborn, infant, children and adults. Vaccine-induced impaired organ development and immunity include impaired mitochondrial function (mitophagy), tissue bioenergetics, loss of balance in Yin (tumoricidal) and Yang (tumorigenic) pathways and altered metabolic-neuronal-hormonal activities as bases for increased induced diseases in young and old.

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Platelet caspase‐1 and Bruton tyrosine kinase activation in patients with COVID‐19 is associated with disease severity and reversed in vitro by ibrutinib

Claude

Martino²,

Hermand³

et al. 2022

Research and Practice in Thrombosis and Haemostasis

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Background: Severity of coronavirus disease 2019 (COVID-19) is often associated with thrombotic complications and cytokine storm leading to intensive are unit (ICU) admission. Platelets are known to be responsible for abnormal hemostasis parameters (thrombocytopenia, raised D-dimers, and prolonged prothrombin time) in other viral infections through the activation of the nucleotide-binding domain leucine repeat rich containing protein 3 inflammasome induced by signaling pathways driven by Bruton tyrosine kinase (BTK) and leading to caspase-1 activation.Objectives: We hypothesized that caspase-1 activation and the phosphorylation of BTK could be associated with the severity of the disease and that ibrutinib, a BTK inhibitor, could inhibit platelet activation. Methods and Results:We studied caspase-1 activation by flow cytometry and the phosphorylation of BTK by Western blot in a cohort of 51 Afro-Carribean patients with COVID-19 disease (19 not treated in ICU and 32 treated in ICU). Patients with a platelet count of 286.7 × 10 9 /L (69-642 × 10 9 /L) were treated by steroids and heparin preventive anticoagulation. Caspase-1 and BTK activation were associated with the severity of the disease and with the procoagulant state of the patients. Furthermore, we showed in vitro that the plasma of ICU patients with COVID-19 was able to increase CD62P expression and caspase-1 activity of healthy platelets and that ibrutinib could prevent it. Conclusions:Our results show that caspase-1 and BTK activation are related to disease severity and suggest the therapeutic hope raised by ibrutinib in the treatment of COVID-19 by reducing the procoagulant state of the patients.

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Inflammation-related effects of adjuvant influenza A vaccination on platelet activation and cardiac autonomic function

Cited by 33 publications

References 42 publications

The Yin–Yang arms of vaccines: disease-fighting power versus tissue-destructive inflammation

The Yin–Yang arms of vaccines: disease-fighting power versus tissue-destructive inflammation

Retracted: Deceptology in cancer and vaccine sciences: Seeds of immune destruction‐mini electric shocks in mitochondria: Neuroplasticity‐electrobiology of response profiles and increased induced diseases in four generations – A hypothesis

Platelet caspase‐1 and Bruton tyrosine kinase activation in patients with COVID‐19 is associated with disease severity and reversed in vitro by ibrutinib

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