Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes

Abstract

T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of environmental factors and genetics, combining with a variety of epigenetic changes. Apart from epigenetic changes of islet β cells and glycometabolic tissues or organs, the inflammation-related epigenetics is also the core pathomechanism leading to β-cell dysfunction and insulin resistance. In this review, we focus on the epigenetic modification of immune cells’ proliferation, recruitment, differentiation and function, providing an overview of the key genes which regulated by DNA methylation, histone modifications, and non-coding RNA in the respect of T2DM. Meanwhile, we further summarize the present situation of T2DM epigenetic research and elucidate its prospect in T2DM clinical diagnosis and treatment.

Bioinformatics Analysis of the Inflammation-Associated lncRNA-mRNA Coexpression Network in Type 2 Diabetes

“…Type 2 diabetes mellitus (T2DM) is a classic metabolic inflammatory disease that is regulated by a combination of environmental and genetic factors [ 10 ]. Inflammation-associated epigenetics is the central pathological mechanism leading to beta-cell dysfunction and insulin resistance [ 11 ]. With the development of molecular biotechnology, ncRNAs, which were once considered “noise,” play a critical role in various biological processes.…”

“…Type 2 diabetes mellitus (T2DM) is a classic metabolic inflammatory disease that is regulated by a combination of environmental and genetic factors [10]. Inflammationassociated epigenetics is the central pathological mechanism leading to beta-cell dysfunction and insulin resistance [11].…”

Bioinformatics analysis of the inflammation-associated lncRNA- mRNA co-expression network in type 2 diabetes

“…In ammation-associated epigenetics is the central pathological mechanism leading to beta-cell dysfunction and insulin resistance [11]. With the development of molecular biotechnology, ncRNAs, which were once considered "noise", play a critical role in various biological processes.…”

Intergenerational Perioperative Neurocognitive Disorder

“…Epigenetic modifications can persist for years and affect all body processes and functions, including neurogenesis, neuroplasticity, cognition, memory, and behavior [ 271 , 272 , 273 , 274 , 275 ]. Various environmental factors, such as stress, inflammation, endocrine-disrupting chemicals, alcohol, substances of abuse, anesthetic agents, and others, can initiate epigenetic modifications [ 271 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 ]. Furthermore, the frequency of epigenetic modifications may accelerate as people age—a phenomenon known as epigenetic drift [ 290 , 291 ].…”