Inflammation related to high-mobility group box-1 in endometrial ovarian cyst

Ikeda, Mariko; Negishi, Yasuyuki; Akira, Shigeo; Morita, Rimpei; Takeshita, Toshiyuki

doi:10.1016/j.jri.2021.103292

Cited by 6 publications

(9 citation statements)

References 52 publications

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“…5,[18][19][20] Previous our study found that the cytoplasmic HMGB1 level increased in antigen-presenting cells (APCs) obtained from EOC and that the activation of the acquired immune system was established more efficiently than the innate immune system. 21 Based on our study and recent reports, it is possible that the sterile inflammation induced by alarmins and their receptors might be involved in the onset or development of endometriosis.…”

Section: Introductionsupporting

confidence: 55%

“…[26][27][28][29][30] Other studies revealed that M2 polarization of macrophages, which could promote an immunosuppressive milieu, occurs in the patients with endometriosis. 31,32 In our current study, Several studies have revealed that HMGB1, 21,[38][39][40] IL-33, 32,41 IL-1α, [42][43][44] and S100 family 45,46 are triggers or aggravating indicators for excessive inflammation in endometriosis [reviewed in Ref. 18 ].…”

Section: Discussionmentioning

confidence: 74%

“…In reproduction, sterile inflammation, alarmins, and their receptors are thought to be involved in various complications, such as infertility, preterm birth, miscarriage, fetal growth restriction, preeclampsia, and endometriosis 5,18–20 . Previous our study found that the cytoplasmic HMGB1 level increased in antigen‐presenting cells (APCs) obtained from EOC and that the activation of the acquired immune system was established more efficiently than the innate immune system 21 . Based on our study and recent reports, it is possible that the sterile inflammation induced by alarmins and their receptors might be involved in the onset or development of endometriosis.…”

Section: Introductionmentioning

confidence: 80%

“…Several studies have revealed that HMGB1, 21,38–40 IL‐33, 32,41 IL‐1α, 42–44 and S100 family 45,46 are triggers or aggravating indicators for excessive inflammation in endometriosis [reviewed in Ref 18 …”

Section: Discussionmentioning

confidence: 99%

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Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis

Shiraishi,

Ikeda,

Watanabe

et al. 2024

American J Rep Immunol

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ProblemIn women of reproductive age, endometriosis may contribute to dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, adenomyosis, and endometrial ovarian cyst (EOC). Recent studies have shown that chronic inflammation occurs in the pelvis of endometriosis patients and that this inflammation is exacerbated by immunosuppression, leading to survival endometrial debris. However, the detailed immunological mechanisms underlying the aggravation of inflammation and immunosuppression in endometriosis patients remain unclear.Method of StudyWe investigate the alarmins (high‐mobility group box‐1, IL‐33, IL‐1α, and S100B protein), proinflammatory cytokines (IL‐6 and IL‐1β), and immune cells (CD8+ T cells, CD4+ T cells, natural killer cells, natural killer T cells, dendritic cells, and macrophages) in peritoneal fluid of patients with EOC using enzyme‐linked immunosorbent assay, electrochemiluminescence, and flow cytometry. Then, we analyzed the correlation between these factors and the aggravating indicators of endometriosis, tumor size and revised American Society for Reproductive Medicine (r‐ASRM) score.ResultsUnexpectedly, there was no correlation between each alarmin level and aggravating indicators. However, the expression of pattern recognition receptors, toll‐like receptor 4, and receptor of advanced glycation end‐products on macrophages was inversely correlated with aggravating indicators.ConclusionsThe aggravation of endometriosis is associated with a decrease in alarmin receptors but not alarmin levels. Investigation of innate immune systems, such as alarmins and their receptors, may help elucidate new mechanisms of endometriosis.

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Section: Introductionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis

Shiraishi,

Ikeda,

Watanabe

et al. 2024

American J Rep Immunol

Self Cite

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“…It is commonly seen in women aged 25 to 45, with an incidence of 10%-15%, and frequent symptoms, including lower abdominal pain, infertility, and dysmenorrhea, adversely affect both health and quality of life[ 1 , 2 ]. There are three types of EMs: Ovarian EMs, peritoneal EMs, and deep invasive EMs, among which ovarian endometriotic cysts (commonly known as chocolate cysts) are a common type, accounting for approximately 80% of EMs, with an incidence of approximately 20%-45% in females with infertility[ 3 , 4 ]. Studies have revealed a relationship between EMs and heredity, immunity, inflammation, and so on[ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Rupture of ovarian endometriotic cyst complicated with endometriosis: A case report

Wang¹,

Jiang²

2021

WJCC

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BACKGROUND Endometriosis (EMs), an estrogen-dependent disease, refers to the appearance of mucosa-covered endometrial tissues (glandular and interstitial) growing in the uterine cavity outside the uterine myometrium. It is commonly seen in women aged 25 to 45, with an incidence of approximately 10%-15%. CASE SUMMARY A 35-year-old unmarried female who denied a history of sex with an intact hymen had multiple dysmenorrhea and pain in the left lower abdomen that recurred during menstruation. Ultrasound examination revealed a dark cystic area measuring 4.9 cm × 4.6 cm on the left side with poor light transmittance, which suggested a left endometriotic cyst. The patient was treated with pain medications (four capsules t.i.d., p.o.). After one month, computed tomography of the abdomen and pelvis revealed a low-density focus measuring approximately 38 mm in diameter, a blurred mesentery fat plane in the pelvic cavity, and pelvic effusion. Ultrasound showed a complex echo density measuring 5.2 cm × 3.0 cm × 4.2 cm in the left ovarian area and a fluid sonolucent area with a depth of 2.0 cm in the pelvic cavity. Left ovarian cystectomy, electrocautery for endometriotic lesions, myomectomy, and pelvic adhesion lysis were performed under laparoscopy. The postoperative diagnosis was left ovarian chocolate cyst rupture and EMs (stage III, ovarian type, peritoneal type). CONCLUSION Laparoscopic surgery can safely control the symptoms of EMs and effectively eradicate the disease.

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CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis

Sun

Wang

et al. 2022

Cell. Mol. Life Sci.

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Inflammation related to high-mobility group box-1 in endometrial ovarian cyst

Cited by 6 publications

References 52 publications

Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis

Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis

Rupture of ovarian endometriotic cyst complicated with endometriosis: A case report

CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis

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