Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit

Liu, Qiuyue; Han, Fang; Pan, Liping; Jia, Hongyan; Li, Qi; Zhang, Zongde

doi:10.3892/etm.2018.5775

Cited by 16 publications

(27 citation statements)

References 37 publications

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“…In contrast, during tuberculous pleurisy, there is no significant increase in MC´s when compared to individuals with nonspecific pleuritis ( 77 ). When studying more severe pulmonary TB among patients admitted to the intensive care units, it was observed that these patients have an increased MCs in lung tissue ( 78 ). In fact, a recent study analyzed fibrotic tissue from post-mortem lung tissue microarrays from individuals with pulmonary TB and healthy control subjects ( 79 ).…”

Section: Mcs and Tuberculosismentioning

confidence: 99%

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

et al. 2022

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The immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease. In this scenario, the role of the different cells involved in the host response, either in terms of innate or adaptive immunity, remains key for defeating this disease. Among this coordinated cell response, mast cells remain key for defeating tuberculosis infection and disease. Together with its effector’s molecules, membrane receptors as well as its anatomical locations, mast cells play a crucial role in the establishment and perpetuation of the inflammatory response that leads to the generation of the granuloma during tuberculosis. This review highlights the current evidences that support the notion of mast cells as key link to reinforce the advancements in tuberculosis diagnosis, disease progression, and novel therapeutic strategies. Special focus on mast cells capacity for the modulation of the inflammatory response among patients suffering multidrug resistant tuberculosis or in co-infections such as current COVID-19 pandemic.

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Section: Mcs and Tuberculosismentioning

confidence: 99%

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

et al. 2022

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“…Despite functions that overlap with •NO and CO, and its involvement in pathophysiological processes, the role of host-generated H 2 S in bacterial pathogenesis has been largely overlooked. Inflammatory responses ( Zumla et al., 2015 ; Liu Q.Y. et al., 2018 ) and metabolic reprogramming of innate and adaptive immune cells are associated with the progression of pulmonary TB ( Shi et al., 2016 ; Kumar et al., 2019 ).…”

Section: Role Of Host H 2 S In Tuberculosismentioning

confidence: 99%

The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

Rahman

Glasgow

Nadeem

et al. 2020

Front. Cell. Infect. Microbiol.

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For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathological processes. Hence, H2S is considered a gasotransmitter along with nitric oxide (•NO) and carbon monoxide (CO). Surprisingly, despite having overlapping functions with •NO and CO, the role of host H2S in microbial pathogenesis is understudied and represents a gap in our knowledge. Given the numerous reports that followed the discovery of •NO and CO and their respective roles in microbial pathogenesis, we anticipate a rapid increase in studies that further define the importance of H2S in microbial pathogenesis, which may lead to new virulence paradigms. Therefore, this review provides an overview of sulfide chemistry, enzymatic production of H2S, and the importance of H2S in metabolism and immunity in response to microbial pathogens. We then describe our current understanding of the role of host-derived H2S in tuberculosis (TB) disease, including its influences on host immunity and bioenergetics, and on Mycobacterium tuberculosis (Mtb) growth and survival. Finally, this review discusses the utility of H2S-donor compounds, inhibitors of H2S-producing enzymes, and their potential clinical significance.

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“…Curcumin also inhibits NF-κB, a protein complex that controls target cell survival, cytokine production and transcription of DNA. Moreover, NF-κB is important in inducing the inflammatory response of the host's immune system causing inflammation and tissue damage [132]; inhibiting NF-κB can decrease DNA replication and proliferation of M. tuberculosis as well as decrease inflammation and tissue damage of the host cell. Fellutamide B, a proteasome inhibitor, may be used as adjunct treatment for tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

et al. 2020

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Tuberculosis (TB), caused by the bacterial organism Mycobacterium tuberculosis, pose a major threat to public health, especially in middle and low-income countries. Worldwide in 2018, approximately 10 million new cases of TB were reported to the World Health Organization (WHO). There are a limited number of medications available to treat TB; additionally, multi-drug resistant TB and extensively-drug resistant TB strains are becoming more prevalent. As a result of various factors, such as increased costs of developing new medications and adverse side effects from current medications, researchers continue to evaluate natural compounds for additional treatment options. These substances have the potential to target bacterial cell structures and may contribute to successful treatment. For example, a study reported that green and black tea, which contains epigallocatechin gallate (a phenolic antioxidant), may decrease the risk of contracting TB in experimental subjects; cumin (a seed from the parsley plant) has been demonstrated to improve the bioavailability of rifampicin, an important anti-TB medication, and propolis (a natural substance produced by honeybees) has been shown to improve the binding affinity of anti-TB medications to bacterial cell structures. In this article, we review the opportunistic pathogen M. tuberculosis, various potential therapeutic targets, available therapies, and natural compounds that may have anti-TB properties. In conclusion, different natural compounds alone as well as in combination with already approved medication regimens should continue to be investigated as treatment options for TB.

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Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit

Cited by 16 publications

References 37 publications

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

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