Inflammatory Abdominal Aortic Aneurysm

Hellmann, David B.; Grand, David; Freischlag, Julie A.

doi:10.1001/jama.297.4.395

Cited by 126 publications

(123 citation statements)

References 30 publications

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“…The treatment for IDA is resection, and the long-term prognosis is generally good without complications. The role for glucocorticoids in aortitis is not well understood at this time, but some studies show that it can have some benefit in preventing recurrence of other aneurysms (7).…”

Section: Discussionmentioning

confidence: 99%

Isolated idiopathic aortitis with an unusually thickened aortic wall: case report

et al. 2016

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Aortitis includes a broad range of disorders involving inflammation of the aorta. While most forms of aortitis can be linked to a specific cause, patients with idiopathic aortitis (IDA), are asymptomatic and usually diagnosed after surgical removal. The specific pathophysiology is not well understood, but can be strongly associated with tobacco smoking, young age at presentation, and family history of aortic aneurysm. Wall thickening is the most common physical characteristic of aortitis, and the inflammation can affect any layer of the aorta.The normal wall thickness of the aorta is less than 4 mm and can be as thick as 9 mm. Few studies document a correlation between wall thickness and the severity of aortitis. This paper presents a unique case of severe aortic aneurysm associated with an abnormal thickening of the ascending aorta.

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Section: Discussionmentioning

confidence: 99%

Isolated idiopathic aortitis with an unusually thickened aortic wall: case report

et al. 2016

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“…20 Approximately 80% of those with an inflammatory AAA [ RESIDENT'S CASE PROBLEM ] experience related pain complaints, compared to the low numbers for those with an atherosclerotic AAA. 42 Although the reported age for this population still remains high (seventh decade), Hellman 21 also described a case of a young adult, 42 years old, with an inflammatory AAA, who, like our patient, presented with a chief complaint of back pain. Also similar were back pain being unaffected by change in position or postures and a history of smoking 20 to 40 cigarettes daily.…”

mentioning

confidence: 59%

“…While the vast majority of patients have an AAA associated with atherosclerotic changes, between 5% and 10% of individuals suffer from an inflammatory AAA. 21,36,42,46 The inflammatory AAAs tend to occur in somewhat younger age groups and are much more likely to be manifested by symptoms such as low back or abdominal pain. 20 Approximately 80% of those with an inflammatory AAA [ RESIDENT'S CASE PROBLEM ] experience related pain complaints, compared to the low numbers for those with an atherosclerotic AAA.…”

mentioning

confidence: 99%

Differential Diagnosis of a Patient Referred to Physical Therapy With Low Back Pain: Abdominal Aortic Aneurysm

Mechelli¹,

Preboski²,

Boissonnault³

2008

J Orthop Sports Phys Ther

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“…Mechanisms of estrogen to protect against AAA formation and/or progression are multifactorial. Inlammation is frequently associated with AAAs [43], and recent studies demonstrated that peripheral blood monocytes contained sex and disease-speciic inlammasome signatures that could be potential biomarkers to determine which patients may have AAAs [44].…”

Section: Inluences Of Sex Hormones On Aaa Development and Progressionmentioning

confidence: 99%

Sexual Dimorphism of Abdominal Aortic Aneurysms

Alsiraj¹,

Thatcher²,

Cassis³

2017

Aortic Aneurysm

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Sex is the largest nonmodiiable risk factor for the development of abdominal aortic aneurysms (AAAs) in humans and experimental models. Data from several studies consistently demonstrate a higher AAA prevalence in males than in females, contributing to divergent recommendations for AAA screening in men and women. Despite a higher AAA prevalence in males, females have more rapid rates of aneurysm dilation, and aneurysms rupture at smaller sizes. Unfortunately, no therapies have been efective to retard aneurysm dilation in either sex. Results from experimental AAA models indicate a protective role for estrogen in AAA development and progression, while male testosterone has been demonstrated to markedly promote angiotensin II (AngII)-induced AAAs. Potential mechanisms implicated in sex hormone regulation of AAAs include regulation of inlammation, matrix metalloproteinases, aromatase activity, oxidative stress, stem cells, and transforming growth factor-beta. In addition to sex hormones, sex chromosomes have been implicated in diseases of the aorta. Turner's syndrome (monosomy X) patients have a high incidence of thoracic aortic rupture. Recent studies indicate a novel approach to deine the relative role of sex hormones versus sex chromosomes in experimental AAAs. Further studies are warranted to determine interactions between sex hormones and sex chromosomes in AAA development and progression.

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Inflammatory Abdominal Aortic Aneurysm

Cited by 126 publications

References 30 publications

Isolated idiopathic aortitis with an unusually thickened aortic wall: case report

Isolated idiopathic aortitis with an unusually thickened aortic wall: case report

Differential Diagnosis of a Patient Referred to Physical Therapy With Low Back Pain: Abdominal Aortic Aneurysm

Sexual Dimorphism of Abdominal Aortic Aneurysms

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