Inflammatory activation in children with primary hypertension

Litwin, Mieczysław; Michałkiewicz, Jacek; Niemirska, Anna; Gockowska, Lidia; Kubiszewska, Izabela; Wierzbicka, Aldona; Wawer, Zbigniew T.; Janas, Roman

doi:10.1007/s00467-010-1548-4

Cited by 54 publications

(36 citation statements)

References 25 publications

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“…Through these effects, adiponectin prevents the development of atherosclerosis while still in early stages. Adiponectin association with vascular changes appears since paediatric ages, as its levels are positively correlated with brachial artery distensibility [52], and inversely correlated with the internal media thickness (IMT) of carotid arteries (cIMT) [56][57][58][59]. However, some intervention programmes did not find any correlation between adiponectin improvement and cIMT [13], cIMT variation [60], or retinal vessel diameter [61].…”

Section: Blood Vessels and Blood Pressure (Bp)mentioning

confidence: 99%

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Nascimento¹,

Coimbra²,

Rêgo³

et al. 2017

Adiposity - Omics and Molecular Understanding

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Paediatric obesity has significant physic, social and psychological implications. Childhood obesity is usually associated in adulthood with increased risk of type 2 diabetes, metabolic syndrome and cardiovascular diseases. Aggregation of cardiometabolic risk factors is already observed at young ages, with a nonlinear association with enhancement of adiposity. Adiponectin is an adipokine that inhibits inflammation, oxidative stress and metabolic syndrome components, namely dyslipidaemia, high blood pressure and insulin resistance. Obesity has been associated with hypoadiponectinaemia in both adult and paediatric patients, which may contribute to co-morbidities observed in these patients. Interventional studies that aim to tackle obesity reported controversial results. Although the general positive effect on weight loss, inflammatory and cardiometabolic markers has been studied, the impact of these interventional studies on adiponectin remains unclear. Some studies reported that the improvement in adiponectin might only occur in paediatric obese patients with great weight loss or intensive physical exercise; the magnitude of the changes in body composition appears to be of particular importance. A revision about the knowledge on the relation between adiponectin, inflammation and cardiometabolic risk factors in paediatric patients is performed; the impact of interventional studies on adiponectin levels and markers of cardiometabolic risk is also addressed.

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Section: Blood Vessels and Blood Pressure (Bp)mentioning

confidence: 99%

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Nascimento¹,

Coimbra²,

Rêgo³

et al. 2017

Adiposity - Omics and Molecular Understanding

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“…35–37 Data from our study (Table 1) demonstrate higher plasma insulin and hsCRP among the obese adolescents compared to both overweight and normal weight adolescent participants. In contrast, FGF23 was significantly higher among adolescents in overweight and obesity groups compared to normal weight groups.…”

Section: Discussionmentioning

confidence: 67%

Fibroblast growth factor-23 is independently associated with cardiac mass in African-American adolescent males

Falkner

Keith

Gidding

et al. 2017

Journal of the American Society of Hypertension

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Left ventricular hypertrophy (LVH) has been documented in hypertensive adolescents and among some with prehypertension. Obesity also appears to be associated with cardiac mass, independent of blood pressure (BP). Fibroblast growth factor-23(FGF23) is a novel biomarker positively associated with LVH in adults with and without kidney disease. The aim of this study was to determine if there was a significant and independent association of FGF23 with cardiac mass in a Black American adolescent cohort including both normotensive and prehypertensive (PH) participants with and without obesity. Measurements of BP, body mass index (BMI), plasma c-terminal FGF23, and echocardiographic measures of left ventricular mass index (LVMI) were obtained in 236 adolescents, aged 13–18 years, stratified by BMI as normal, overweight, or obese. LVMI differed significantly between normal, overweight, and obese groups (30.42±6.75 vs 33.49 ±8.65 vs 37.26±6.99 gm/m2.7; P<0.01). FGF23 was significantly higher in both overweight (53.03 RU/ml) and obese (54.40 RU/ml) compared to the normal weight (32.83 RU/ml) group; both P<0.01). In multiple linear regression analysis, variables significantly related to LVMI in males were BMI (P<0.0001), and FGF23 (P=0.005), but not BP, hsCRP or insulin. The only significant variable associated with LVMI in females was BMI (P<0.0001). In males, the contribution of FGF23 to predicting LVMI was independent of and in addition to obesity. These results suggest that FGF23 is an integral part of a complex pathway, associated with higher cardiac mass in African Americans males with excess adiposity.

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“…Lp(a) bağımsız bir kardiyovasküler risk faktörü olup yapılan çalışmalar ışığında prematür kardiyovasküler hastalıkla ilişkili olduğu gösterilmiştir. 26 hsCRP seviyelerinin de diğer faktörlerden bağımsız olarak hipertansif hastalarda yükseldiği gösterilmiştir. [27][28][29] Çalışmamızda hsCRP ve Lp(a) değerleri evre 2 hipertansiyonlu grupta anlamlı olarak daha yüksek bulundu.…”

Section: Discussionunclassified

Is the Childhood Primary Hypertension Causes Target Organ Damage?

Şahan¹,

Sözeri²,

Devecí³

et al. 2016

Turkiye Klinikleri J Pediatr

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Ö ÖZ ZE ET T A Am ma aç ç: : Çocukluk çağında primer hipertansiyonun yüksek kardiyovasküler mortalite ve morbidite ile ilişkisi son yıllarda ciddi bir sağlık sorunu hâline gelmiş ve giderek önem kazanmıştır. Bu çalışmada, primer hipertansiyonlu çocuklarda geleneksel ve geleneksel olmayan risk faktörleri ve bu faktörlerin hedef organ hasarı üzerine etkisinin araştırılması amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Primer hipertansiyon tanısı alan 7-18 yaş arasındaki 50 hasta ile aynı yaş grubunda sağlıklı 100 kişi kontrol grubu olarak çalışmaya alındı. Hasta grubuna 24 saatlik yaşam içi kan basıncı ölçümü yapıldı. Biyokimyasal olarak kan lipitleri, hs CRP, Lp(a) bakıldı. Hedef organ tutulumu açısından retinopati, nefropati (24 saatlik idrarda mikroalbuminüri), kardiyopati (sol ventrikül hipertrofisi ve sol ventrikül kitle indeks) ve vaskülopati (karotis intima mediya kalın-lığı ve arteriyel katılık) değerlendirildi. B Bu ul lg gu ul la ar r: : Toplam 50 (35 erkek, 15 kız) hastada ortalama yaş 13,1±3,2 yıl, 100 (54 erkek, 46 kız) sağlıklı kontrolde 13,06±2,7 yıl idi. Hastaların 17 (%34)'sinde göz dibi etkilenmesi mevcuttu (14 (%28)'ünde evre 1, 3 (%6)'ünde evre 2 hipertansif retinopati). Bir (%2) hastada ekokardiyografik olarak sol ventrikül hipertrofisi görüldü. Sol ventrikül kitle indeksi 7 (%14) hastada yüksek saptandı (Ort: 28,32±11,43 g/m2,7). 26 (%52) hastada cIMT (sağda 0,468±0,062, solda 0,472±0,064 mm, kontrol grubunda sağda 0,406±0,041, solda 0,405±0,041; p=0,000), 18 (%36) hastada PWV (5,76±0,84 m/s, kontrol grubunda 5,30±0,70 m/s; p=0,000), 11 (%22) hastada santral augmentasyon indeksi (%10,54±6,56, kontrol grubunda %9,41±8,54; p=0,366) yüksek bulundu. Hastalığın şiddeti arttıkça mikroalbuminüri ve inflamasyon göstergelerinin anlamlı olarak arttığı, HDL değerlerinin düştüğü görüldü. Beyaz önlük hipertansiyonu saptanan 8 hastada değişik derecelerde hedef organ tutulumu saptandı. S So on nu uç ç: : Çocukluk çağında primer hipertansiyon, hedef organ hasarı yapması nedeni ile erken tanınması ve tedavi edilmesi gereken bir durumdur.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Hipertansiyon; organ; çocuk A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The primary hypertension in childhood that is related with high cardiovascular morbidity and mortality has been a serious health problem in recent years and has become more important. In this study, the exploration of the effects of traditional and nontraditional risk factors over target organ damage in children with primary hypertension is aimed. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 50 patients who are between 7-18 years old and diagnosed as primary hypertension and 100 healthy children in the same age as a control group were evauated in study. Ambulatory blood pressure measurement within 24 hours was performed to the patient group. Biochemically, blood lipids, hs CRP, Lp(a) were measured. In terms of target organ involvement, retinopathy, nephropathy (microalbuminuria in 24-hour urine), car...

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Inflammatory activation in children with primary hypertension

Cited by 54 publications

References 25 publications

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Adiponectin, Inflammation and Cardiometabolic Risk Factors in Paediatric Obese Patients: Impact of Interventional Studies

Fibroblast growth factor-23 is independently associated with cardiac mass in African-American adolescent males

Is the Childhood Primary Hypertension Causes Target Organ Damage?

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