Inflammatory and antioxidant pathway dysfunction in borderline personality disorder

MacDowell, Karina S.; Marsá, M Díaz; Buenache, Eva; Villatoro, Jose Manuel Lopez; Moreno, Beatriz; Leza, Juan C.; Carrasco, José Luís

doi:10.1016/j.psychres.2020.112782

Cited by 33 publications

(29 citation statements)

References 49 publications

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“…Some studies in literature highlight the correlation between immune-mediated inflammation and psychiatric disease. However, there are few studies about the efficacy of IV immunoglobulins in psychiatric features which will needed to have more evidence and to better understanding the mechanism of action [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…IVIGs regulate the immune system with multiple mechanisms: modulation of Fc receptor function, interference with cytokine release and function; interference with complement activation; presence of anti-idiotype antibodies; modulation of B and T lymphocyte activity. There are few studies about the efficacy of IV immunoglobulins in psychiatric features [8][9][10].…”

Section: C)mentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of IV Immunoglobulins on Psychiatric Symptoms: A Case Report

Silva¹,

Gastaldi

Placenti

et al. 2021

BJSTR

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Section: Discussionmentioning

confidence: 99%

Section: C)mentioning

confidence: 99%

Efficacy of IV Immunoglobulins on Psychiatric Symptoms: A Case Report

Silva¹,

Gastaldi

Placenti

et al. 2021

BJSTR

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“…3A and B). It has been reported that COX2 is a highly expressed inflammatory factor (31). Thus, the present study investigated whether flurbiprofen inhibits the expression of inflammatory factors by inhibiting COX2.…”

Section: Flurbiprofen Inhibits Colorectal Cancer Cell Proliferationmentioning

confidence: 92%

Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2

Wang

Zhang

et al. 2020

Oncol Lett

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Colorectal cancer is an aggressive disease with a poor prognosis and low survival rate at the advanced stage, therefore new innovative targets are urgently required. Flurbiprofen has been reported to exhibit therapeutic effects in other types of cancer, such as esophageal cancer, breast cancer and colorectal cancer. Therefore, the present study aimed to investigate the function of flurbiprofen in colorectal cancer. SW620 colorectal cancer cells were treated with different concentrations of flurbiprofen to determine the optimum concentration. Subsequently, COX2 expression affected by flurbiprofen was tested using western blotting, reverse transcription-quantitative PCR and immunofluorescence. Enzyme-linked immunosorbent assay was used to determine the levels of tumor necrosis factor-α, interleukin (IL)-6 and IL-1β. Cell Counting Kit-8, colony formation and flow cytometry assays were used to assess the proliferation and apoptosis of SW620 cells in various groups. Western blotting was performed to investigate the expression of proliferation-, apoptosis-and migration-related proteins after different treatments. Wound healing and Transwell assays were performed to measure the invasion and migration of colorectal cancer cells, respectively. The results demonstrated that flurbiprofen inhibited colorectal cancer cell proliferation. Furthermore, it was identified that flurbiprofen inhibited the expression of COX2. Notably, flurbiprofen suppressed the expression of inflammatory factors by inhibiting COX2. Moreover, flurbiprofen inhibited the proliferation, invasion and migration of colorectal cancer cells by inhibiting COX2. In conclusion, the present study revealed that flurbiprofen inhibited COX2 expression in colorectal cancer, and affected the proliferation, invasion, migration and apoptosis of colorectal cancer cells. These results expand the understanding of the function of COX2 in colorectal cancer and the effect of flurbiprofen on COX2 expression.

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“…The blood sample processing and the specimen quantification protocols employed in this research are described elsewhere (Caso et al, 2020;MacDowell et al, 2020).…”

Section: Blood Sample Collection and Inflammatory Markersmentioning

confidence: 99%

“…Mounting evidence has shown increased inflammatory activity in people with higher levels of depressive symptoms (highly present in people with ED) and beneficial effects of antiinflammatory treatments on depressive patients (de la Torre-Luque, Ayuso-Mateos, Sanchez-Carro, de la Fuente, & Lopez-Garcia, 2019;Kohler, Krogh, Mors, & Eriksen Benros, 2016;Zalli, Jovanova, Hoogendijk, Tiemeier, & Carvalho, 2016). Other ED co-occurring conditions have also been associated with an increased proinflammatory response, such as posttraumatic stress disorder or borderline personality disorder (MacDowell et al, 2020;Renna, O'Toole, Spaeth, Lekander, & Mennin, 2018). These disorders may show some shared symptoms with ED, such as aberrant emotional reactivity and difficulties in emotion regulation (De Paoli, Fuller-Tyszkiewicz, Huang, & Krug, 2020;Echeverri-Alvarado, Pickett, & Gildner, 2020;Fitzgerald et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory dysregulation in women with an eating disorder: Relationships with altered emotional reactivity

Dı́az-Marsá

MacDowell

laTorre-Luque

et al. 2021

Intl J Eating Disorders

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BackgroundSome studies suggest that inflammatory signaling dysregulation may contribute to eating disorder (ED) pathophysiology. However, little is known about the influence of inflammatory response on altered processes seen among patients with ED, such as emotional processing and reactivity.ObjectivesThe objectives were: (a) to investigate the systemic inflammatory response in ED women; and (b) to analyze the role of inflammatory markers in emotional reactivity.MethodConcentrations of several intercellular and intracellular inflammatory mediators (cytokines, prostaglandin by‐products and enzymes, TBARS, and MAPK proteins) were quantified in plasma and PBMCs from 68 women with an ED (m = 22.01 years, SD = 9.15) and 35 healthy controls (m = 18.54 years, SD = 4.21). Moreover, emotional reactivity to affective pictures (those without either food or thinness content) was studied using the adult (>18 years old) sample (n = 41).ResultsBetween‐group differences were revealed for most markers (TNF‐α, PGE2, COX2, and ratio of activated MAPK proteins), pointing to increased inflammatory response in patients (p < .01). Women with ED showed heightened emotional reactivity, regardless of picture valence. Principal components derived from inflammatory markers showed an explanatory loading on patient's emotional reaction, in terms of valence and arousal.ConclusionThis study corroborates the altered systemic inflammatory response in patients with ED. The inflammatory dysregulation may contribute to ED phenotype, as seen by its relationship with heightened emotional reactivity, even though the inflammatory markers were not evaluated throughout the emotional reactivity protocol.

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Inflammatory and antioxidant pathway dysfunction in borderline personality disorder

Cited by 33 publications

References 49 publications

Efficacy of IV Immunoglobulins on Psychiatric Symptoms: A Case Report

Efficacy of IV Immunoglobulins on Psychiatric Symptoms: A Case Report

Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2

Inflammatory dysregulation in women with an eating disorder: Relationships with altered emotional reactivity

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