Inflammatory and immunomodulatory roles of TGF-β

Wahl, Sharon M.; McCartney-Francis, Nancy; Mergenhagen, Stephan E.

doi:10.1016/0167-5699(89)90136-9

Cited by 431 publications

(154 citation statements)

References 24 publications

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“…The transforming growth factors P (TGFP) are a family of disulfide-bonded 25-kd dimeric proteins that modulate the growth of a variety of cells (12,13). Three related proteins, TGFP1, TGFP2, and TGFP3, have been identified.…”

Section: Tgfp1 In Msu Crystal-induced Inflammation 1193mentioning

confidence: 99%

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Inhibition and prevention of monosodium urate monohydrate crystal–induced acute inflammation in vivo by transforming growth factor β1

Lioté

Prudhommeaux

Schiltz

et al. 1996

Arthritis & Rheumatism

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Objective. We investigated the effects of transforming growth factor Pl (TGFP1) on monosodium urate monohydrate (MSU) crystal-induced acute inflammation in vivo.Methods. One hour after MSU crystal-induced acute inflammation was produced in the rat subcutaneous air pouch model, the effects of recombinant human TGFPl (rHuTGFP1; 10-100 pglanimal) and ultrapure TGFPl (UPTGFPI; 100 and 500 pglanimal) were assessed, based on absolute and differential white blood cell counts in the exudate. The effects of 10 pg of rHuTGFP1 preincubated with a specific anti-TGFP antibody, and the effects of coinjection of crystals and rHuTGFP1, were also studied.Results. UPTGFPl and rHuTGFPl markedly reduced MSU crystal-induced inflammation. Recombinant human TGFPl also reduced inflammation when administered concomitantly with MSU crystals. Moreover, rHuTGFPl and UPTGFP1, injected l hour after MSU crystal injection, reduced the inflammatory response in a dose-dependent manner. Injection of rHuTGFPl (100 pglanimal) resulted in a >9w0 reduction in the maximal white blood cell count, achieved 6 hours after Spontaneous resolution is an important clinical feature of gouty attacks that is not yet fully understood (1,2). Lowering of pH and stimulation of phagocyte oxidative metabolism during crystal-induced inflammation may promote monosodium urate monohydrate (MSU) crystal dissolution. However, this cannot entirely explain the self-limited nature of gouty inflammation, since MSU crystals can remain in the synovial fluid after acute inflammation and have been identified in noninflammatory synovial fluids from gout patients (3).In vitro (4) and in vivo ( 5 ) studies have shown that changes in the protein coating of MSU crystals and in other as-yet-unidentified components that are generated locally during subsiding inflammation probably contribute to the self-limited nature of acute gouty arthritis (6). There is strong in vitro evidence that proinflammatory cytokines such as interleukin-lP (ILlP), tumor necrosis factor P (TNFP), IL-6, and IL-8 (7-1 1) are released within hours when monocytes and macrophages are incubated with MSU crystals. Natural cytokine inhibitors such as IL-1 receptor antagonist (IL-1Ra) and/or soluble TNFa receptor, or other regulatory cytokines such as IL-4 and IL-10, may block acute and subsequent chronic inflammation.

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Section: Tgfp1 In Msu Crystal-induced Inflammation 1193mentioning

confidence: 99%

“…Three related proteins, TGFP1, TGFP2, and TGFP3, have been identified. They modulate extracellular matrix deposition (14), immune system function (13,15), inflammation and repair processes (14,16), and other biologic effects. TGFPs are the most potent known chemotactic factors for macrophages (17).…”

Section: Tgfp1 In Msu Crystal-induced Inflammation 1193mentioning

confidence: 99%

Inhibition and prevention of monosodium urate monohydrate crystal–induced acute inflammation in vivo by transforming growth factor β1

Lioté

Prudhommeaux

Schiltz

et al. 1996

Arthritis & Rheumatism

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“…TGF-[3 may promote angiogenesis and wound healing and also acts as a potent immunosuppressive factor by inhibiting proliferation of bone marrow progenitor cells, of T-and B-cell lineages as well as their functions, including B-cell immunoglobulin synthesis, lymphokine-activated killer (LAK) cytotoxicity, natural killer (NK) cytotoxicity and T-cell cytotoxicity (Wahl et al, 1989). Overexpression of TGF-P and loss of growth inhibition have been described in melanoma cell lines in vitro (MacDougall et al, 1993;Krasagakis et al, 1994;Rodeck et al, 1994).…”

mentioning

confidence: 99%

Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma

Krasagakis

Thölke²,

Farthmann³

et al. 1998

Br J Cancer

136

101

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Summary Overexpression of transforming growth factor-4 isoforms (TGF-f1, -P2, -,B3) has been previously reported in human melanoma cell lines and tumours. The aim of the present study was to evaluate the plasma levels of TGF-f isoforms in melanoma patients. Significantly elevated levels of TGF-,1l (4.2 x the controls, P= 0.0094) and of TGF-,2 (1.5 x the controls, P= 0.012) but not of TGF-13 were measured in patients with disseminated but not locoregional melanoma. These results indicate systemic circulation of potentially immunosuppressive peptides of the TGF-P family in end-stage melanoma patients.

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“…TGF-β1, a cytokine produced by activated macrophages and other cells, is a potent pro-inflammatory and immunosuppressive molecule with a plethora of immunoregulatory effects which are described as bifunctional (Wahl et al 1989), in addition to effects on cell growth and differentiation (Wakefield et al 1988). The immunosuppressive effect of TGF-β1 on leprosy lesions is more evident by the inhibition of the production of intermediate oxygen-reactive and nitrogen-reactive factors (Tsunawaki et al 1988, Ding et al 1990), leading to the progression of infection.…”

Section: Immunopathological Mechanisms In Leprosy -mentioning

confidence: 99%

Leprosy, a neglected disease that causes a wide variety of clinical conditions in tropical countries

Foss

Motta

2012

Mem. Inst. Oswaldo Cruz

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Inflammatory and immunomodulatory roles of TGF-β

Cited by 431 publications

References 24 publications

Inhibition and prevention of monosodium urate monohydrate crystal–induced acute inflammation in vivo by transforming growth factor β1

Inhibition and prevention of monosodium urate monohydrate crystal–induced acute inflammation in vivo by transforming growth factor β1

Elevated plasma levels of transforming growth factor (TGF)-β1 and TGF-β2 in patients with disseminated malignant melanoma

Leprosy, a neglected disease that causes a wide variety of clinical conditions in tropical countries

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