Inflammatory and metabolic disturbances are associated with more severe trajectories of late-life depression

Torre‐Luque, Alejandro de la; Ayuso-Mateos, José Luís; Sanchez-Carro, Yolanda; J, de la Fuente; López-García, Pilar

doi:10.1016/j.psyneuen.2019.104443

Cited by 15 publications

(8 citation statements)

References 58 publications

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“…There are also many possible biomarkers implicated in the etiology/relapse of MDD. Included among them are excessive levels of baseline IL-6, CRP, and/or fibrinogen (Chu et al, 2019; de la Torre-Luque et al, 2019; Eswarappa et al, 2019; Fancourt & Steptoe, 2020; Gimeno et al, 2009; Hamer et al, 2009; Kang et al, 2016; Khandaker et al, 2014; Lamers et al, 2019; Smith et al, 2018; Valkanova et al, 2013; Wium-Andersen et al, 2013; Zalli et al, 2016). Thus, our study examined these three biomarkers.…”

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confidence: 99%

“…Thus far, 18 empirical studies have tested if baseline levels of IL-6, CRP, or fibrinogen were linked to future heightened depression or related constructs across many years. Excessive IL-6, CRP, or fibrinogen at baseline predicted elevated depression severity, persistence, or reduced well-being and physical activity 4 to 12 years later in community-dwelling British children, adolescents, young-to-middle-aged adults (Chu et al, 2019; de la Torre-Luque et al, 2019; Fancourt & Steptoe, 2020; Hamer et al, 2009; Khandaker et al, 2014; Zalli et al, 2016), and civil servants (Gimeno et al, 2009). Likewise, greater initial levels of IL-6 were related to MDD diagnostic status and chronicity across 1 to 10 years among nonstatin-medicated stroke patients in South Korea (Kang et al, 2016) and community-dwelling adults in the Netherlands (Lamers et al, 2019) and Spain (de la Torre-Luque et al, 2019).…”

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confidence: 99%

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Increased inflammation predicts nine-year change in major depressive disorder diagnostic status.

Zainal¹,

Newman²

2021

Journal of Abnormal Psychology

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Cytokine theory of depression proposes that increased baseline inflammatory activity may accumulate over time and lead to future major depressive disorder (MDD). However, most research conducted on this topic has been cross-sectional and examined between-(vs. within-) persons and symptom severity (vs. diagnosis). Therefore, we tested if elevated inflammatory activity at Time 1 (T1) would predict future within-person 9year change in MDD diagnosis. Community-dwelling adults (n = 945) participated in the Midlife Development in the United States (MIDUS) study. T1 and Time 2 (T2) MDD status was assessed using the Composite International Diagnostic Interview-Short Form, and markers of inflammatory activity at T1 were measured (e.g., levels of serum interleukin-6 [IL-6], C-reactive protein [CRP], fibrinogen). Latent change score modeling was conducted. Higher T1 IL-6, CRP, and fibrinogen levels of inflammatory activity predicted T1-T2 development/relapse of MDD within persons. This effect occurred more strongly among women (vs. men; d = .149 vs. .042), younger (vs. older) adults (d = .137 vs. .119), persons with more (vs. less) chronic health issues (d = .133 vs. .065), low-(vs. middle-or high-) income earners (d = .161 vs. .050), and persons with more (vs. less) frequent childhood trauma (d = .156 vs. .017). Findings aligned with expanded cytokine theories, which posit that the impact of increased T1 inflammatory activity on future change in MDD status will be larger for subgroups vulnerable to increased stress exposure. Cognitive-behavioral or pharmacological approaches to reduce markers of inflammatory activity may prevent development/relapse of MDD.

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confidence: 99%

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Increased inflammation predicts nine-year change in major depressive disorder diagnostic status.

Zainal¹,

Newman²

2021

Journal of Abnormal Psychology

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“…Geriatrik dönemdeki depresif bozukluk hastalarında CRP düzeyi ile depresyonun şiddeti arasında pozitif yönde güçlü bir ilişki olabileceği düşünülmüştür (12). Aynı zamanda artmış inflamasyon ile geriatrik depresyonun daha şiddetli gidişi (13), kognitif belirtiler (14) ve kırılganlık (15) This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.…”

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Do late and early onset depression differ in terms of inflammation?

Özdin¹,

Özdin²

2020

Dusunen Adam

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“…Thus, some relevant covariates, such as age and depression were not included in the analyses (Dalton, Bartholdy, et al, 2018). Mounting evidence has shown increased inflammatory activity in people with higher levels of depressive symptoms (highly present in people with ED) and beneficial effects of antiinflammatory treatments on depressive patients (de la Torre-Luque, Ayuso-Mateos, Sanchez-Carro, de la Fuente, & Lopez-Garcia, 2019;Kohler, Krogh, Mors, & Eriksen Benros, 2016;Zalli, Jovanova, Hoogendijk, Tiemeier, & Carvalho, 2016). Other ED co-occurring conditions have also been associated with an increased proinflammatory response, such as posttraumatic stress disorder or borderline personality disorder (MacDowell et al, 2020;Renna, O'Toole, Spaeth, Lekander, & Mennin, 2018).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory dysregulation in women with an eating disorder: Relationships with altered emotional reactivity

Dı́az-Marsá

MacDowell

laTorre-Luque

et al. 2021

Intl J Eating Disorders

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BackgroundSome studies suggest that inflammatory signaling dysregulation may contribute to eating disorder (ED) pathophysiology. However, little is known about the influence of inflammatory response on altered processes seen among patients with ED, such as emotional processing and reactivity.ObjectivesThe objectives were: (a) to investigate the systemic inflammatory response in ED women; and (b) to analyze the role of inflammatory markers in emotional reactivity.MethodConcentrations of several intercellular and intracellular inflammatory mediators (cytokines, prostaglandin by‐products and enzymes, TBARS, and MAPK proteins) were quantified in plasma and PBMCs from 68 women with an ED (m = 22.01 years, SD = 9.15) and 35 healthy controls (m = 18.54 years, SD = 4.21). Moreover, emotional reactivity to affective pictures (those without either food or thinness content) was studied using the adult (>18 years old) sample (n = 41).ResultsBetween‐group differences were revealed for most markers (TNF‐α, PGE2, COX2, and ratio of activated MAPK proteins), pointing to increased inflammatory response in patients (p < .01). Women with ED showed heightened emotional reactivity, regardless of picture valence. Principal components derived from inflammatory markers showed an explanatory loading on patient's emotional reaction, in terms of valence and arousal.ConclusionThis study corroborates the altered systemic inflammatory response in patients with ED. The inflammatory dysregulation may contribute to ED phenotype, as seen by its relationship with heightened emotional reactivity, even though the inflammatory markers were not evaluated throughout the emotional reactivity protocol.

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Inflammatory and metabolic disturbances are associated with more severe trajectories of late-life depression

Cited by 15 publications

References 58 publications

Increased inflammation predicts nine-year change in major depressive disorder diagnostic status.

Increased inflammation predicts nine-year change in major depressive disorder diagnostic status.

Do late and early onset depression differ in terms of inflammation?

Inflammatory dysregulation in women with an eating disorder: Relationships with altered emotional reactivity

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