Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection

López-Castaneda, Sandra; García-Larragoiti, Nallely; Cano-Méndez, Alan; Blancas-Ayala, Kenia; Damián-Vázquez, Guadalupe; Perez-Medina, Ana Itzel; Chora-Hernández, Luis David; Arean-Martínez, Carlos; Viveros-Sandoval, Martha Eva

doi:10.1177/1076029621999099

Cited by 52 publications

(65 citation statements)

References 35 publications

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“…It mediates the interaction of activated platelets on endothelium with leukocytes playing a key role in the thrombotic process 10,11 . A significantly increased P-selectin concentration in plasma samples of severe COVID-19 patients compared to healthy controls, together with other prothrombotic biomarkers has been recently demonstrated 12,13 .…”

Section: Introductionmentioning

confidence: 94%

SELP Asp603Asn and severe thrombosis in COVID-19 males: implication for anti P-selectin monoclonal antibodies treatment

Fallerini

Daga

Benetti

et al. 2021

Preprint

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Thromboembolism is a frequent cause of severity and mortality in COVID-19. However, the etiology of this phenomenon is not well understood. A cohort of 1,186 subjects, from the GEN-COVID consortium, infected by SARS-CoV-2 with different severity were stratified by sex and adjusted by age. Then, common coding variants from whole exome sequencing were mined by LASSO logistic regression. The homozygosity of the cell adhesion molecule P-selectin gene (SELP) rs6127 (c.1807G>A; p.Asp603Asn) which increases platelet activation is found to be associated with severity in the male subcohort of 513 subjects (Odds Ratio= 2.27, 95% Confidence Interval 1.54-3.36). As the SELP gene is downregulated by testosterone, the odd ratio is increased in males older than 50 (OR 2.42, 95% CI 1.53-3.82). Asn/Asn homozygotes have increased D-dimers values especially when associated with poly Q≥23 in the androgen receptor (AR) gene (OR 3.26, 95% CI 1.41-7.52). These results provide a rationale for the repurposing of antibodies against P-selectin as adjuvant therapy in rs6127 male homozygotes especially if older than 50 or with impaired AR gene.

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Section: Introductionmentioning

confidence: 94%

SELP Asp603Asn and severe thrombosis in COVID-19 males: implication for anti P-selectin monoclonal antibodies treatment

Fallerini

Daga

Benetti

et al. 2021

Preprint

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“…Clinical and biochemical indices and cytokines have been widely investigated. Low lymphocyte and neutrophil percentages and elevated C-reactive protein (CRP) are the most common abnormalities related to SARS-CoV-2 infection and correlated with acute lung injury [9]. Regarding cytokine production, many cytokines and chemokines have been evaluated to improve patient management and enable a targeted personalized approach.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding cytokine production, many cytokines and chemokines have been evaluated to improve patient management and enable a targeted personalized approach. Overproduction of the proin ammatory cytokines IL-1, IL-6, IL-8 and TNF-α and low of expression IFN-γ have been found in severe COVID-19 patients [9,10] Another proin ammatory cytokine, IL-32, activates signalling pathways of mitogen-activated protein kinases (MAPKs) and of nuclear factor (NF)-κB. It is produced by various epithelial and immune cells such as T lymphocytes, NK cells and monocytes.…”

Section: Introductionmentioning

confidence: 99%

Cytokine Profiles in the Detection of Severe Lung Involvement in Hospitalized Patients With COVID-19: the IL-8 – IL-32 axis

Bergantini

d’Alessandro

Cameli

et al. 2021

Preprint

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Coronavirus disease 2019 (COVID-19) is an infectious respiratory disorder caused by a new coronavirus called SARS-CoV-2. The pathophysiology of severe COVID-19 is associated with a “cytokine storm”, characterized by anomalous release of various pro-inflammatory cytokines which contribute to alveolar exudation and lung damage. Overproduction of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF-α and low of expression IFN-γ have been found in severe COVID-19 patients. The mechanism by which IL-32 exerts its signalling properties is unclear. IL-32 is a key modulator in the pathogenesis of various clinical conditions and is mostly induced by IL-8. IL-32 modulates important inflammatory pathways (including TNF-α, IL-6 and IL-1b), contributing to the pathogenesis of inflammatory diseases. A total of 64 COVID-19 patients, stratifying as mild moderate and severe patients and 27 healthy controls were consecutively enrolled in the study. Serum concentrations of biomarkers including IL-1β, IL-10, IFN-γ, TNF-α and IL-6 were quantified by bead-based multiplex analysis and Serum concentration of IL-8 and IL-32 were determined by enzyme-linked immunosorbent assay (ELISA) kits. Interestingly, among the blood parameters, neutrophil and lymphocyte counts were significantly lower in severe COVID-19 patients than in the other, on the contrary, CRP was significantly higher in severe patients than in other groups. The cytokines that best distinguished controls from COVID-19 patients were IL-8 and IL-32.The best model performance for severe group was obtained by the combination of IL-32, IL-6 and IFN-γ, and serum concentrations of CRP increased model performance, showing AUC=0.83. New insights into the cytokine storm in COVID-19 patients, highlighting specific cytokine signatures among patients with different severity of infection.

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“…Similarly, a significant proportion of patients with high D dimer, suggesting a prothrombotic state in COVID-19. [14][15][16] High liver enzymes and creatinine were probably systemic responses of COVID-19 infection and may affect prognosis. 17 High random glucose in around 90% of patients were due to inflammatory response along with steroid use.…”

Section: Discussionmentioning

confidence: 99%

Death profiling of hospitalized patients with COVID-19: Experience from a specialized hospital in Bangladesh

Morshed¹,

Mosabbir

Hossain

2021

Preprint

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Background: The information on characteristics and causes of mortality in deceased patients with coronavirus disease 2019 (COVID-19) is scarce in the literature. This study aimed to document the clinical profile with causes of death in deceased patients admitted in a COVID-19 dedicated hospital in Dhaka, Bangladesh. Methods: This cross-sectional retrospective study included 108 COVID-19 associated deceased patients admitted in Kurmitola general hospital, Dhaka, Bangladesh between 25 March 2020 and 24 June 2020) Data were collected from hospital record. Causes of death were categorized into early and late with cut-off of 48 hours of hospitalization. Results: Among 809 hospitalized cases of COVID-19, 108 patient died (13.35%) over three months of study period. The mean age of the deceased patients was 60.2 (SD 13.94) years; 86.1% were male. About 85% had at least one comorbidity with diabetes mellitus (65.7%) was the most common one. The most common symptoms were breathlessness (88.0%), fever (65.7%) and cough (43.5%). Nearly 75% presented with severe disease. Patients had altered biochemical profiles and treated with different drugs including antibiotics and steroids. Young age and malnutrition were two characteristic features. Only one third got intensive care support. The most common cause of death was acute respiratory syndrome (95.37%). Septic shock & acute myocardial infarction were predominantly early and uremia, hepatic failure & hyperglycemic crisis were the predominant causes of late hospital death. Conclusions: The findings of this study will help clinicians as well as policy makers to take necessary steps to prevent death from COVID-19 in Bangladeshi population.

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Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection

Cited by 52 publications

References 35 publications

SELP Asp603Asn and severe thrombosis in COVID-19 males: implication for anti P-selectin monoclonal antibodies treatment

SELP Asp603Asn and severe thrombosis in COVID-19 males: implication for anti P-selectin monoclonal antibodies treatment

Cytokine Profiles in the Detection of Severe Lung Involvement in Hospitalized Patients With COVID-19: the IL-8 – IL-32 axis

Death profiling of hospitalized patients with COVID-19: Experience from a specialized hospital in Bangladesh

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