Inflammatory and thrombotic mechanisms in coronary atherosclerosis

Tousoulis, D; Davies, Graham; Stefanadis, Christodoulos; Toutouzas, Pavlos; Ambrose, John A.

doi:10.1136/heart.89.9.993

Cited by 133 publications

(88 citation statements)

References 80 publications

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“…These results support the concept of the contribution of fibrin in intravascular atherothrombogenesis 10 . Decreased fibrinolytic activity, mainly caused by the increase in plasma PAI-1concentration, has been associated with CAD in several studies 11 .…”

Section: Discussionsupporting

confidence: 80%

Associação de níveis plasmáticos de PAI-1 e polimorfismo 4G/5G em pacientes com doença arterial coronariana

Lima

Carvalho

Neto

et al. 2011

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 80%

Associação de níveis plasmáticos de PAI-1 e polimorfismo 4G/5G em pacientes com doença arterial coronariana

Lima

Carvalho

Neto

et al. 2011

Arq. Bras. Cardiol.

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“…Signs of local and systemic non-specific inflammatory processes in atherosclerosis trace to the earliest stages of vascular lesion development [8] . Increased oxidation of LDL contributes to their diffusion into the subendothelial space and activation of nuclear factor kappa-B (NF-kB) through interaction with toll-like receptors.…”

Section: Introductionmentioning

confidence: 99%

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

Nikiforov¹,

Galstyan²,

Недосугова³

et al. 2017

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How to cite this article: Nikiforov NG, Galstyan KO, Nedosugova LV, Elizova NV, Kolmychkova KI, Ivanova EA. Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease. Vessel Plus 2017;1:192-5.Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and stimulated secretion of tumor necrosis factor alpha (TNF-α) was observed in diabetic patients compared with healthy subjects. On the contrary, in patients with CHD, decreased secretion of the pro-inflammatory cytokine, TNF-α, was found. A direct correlation between glycated hemoglobin (HbA1c) levels in T2DM patients and basal secretion of TNF-α from monocytes was observed. Conclusion: The authors found diametrically different responses of monocytes from T2DM and CHD under pro-inflammatory stimuli. Key words:Type 2 diabetes mellitus, coronary heart disease, M1/M2 monocyte polarization, oxidative stress, atherosclerosis, inflammatory ABSTRACTArticle history:

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“…Hence, it is important to develop means to more accurately predict CVD events such as psychological depression. Several inflammatory markers, including high sensitivity C-reactive protein (hsCRP), have been identified in atherosclerotic lesions, contributing to acute thrombotic complications [6]. Circulating levels of the pro-inflammatory cytokine(s), growth factor(s) (GFs), and their soluble receptors (R), such as EGF-R/HER-1/erbB-1, may be associated with CHF severity [7].…”

Section: Introductionmentioning

confidence: 99%

Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production

2011

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The EGF-R, also known as HER-1 or erbB-1 (EGF-R/HER-1/erbB-1), is a member of the human epithelial receptor tyrosine kinase family. sEGF-R is considered to play a role in cardiac (patho)physiology. We aimed to investigate whether soluble EGF-R is increased in congestive heart failure (CHF) patients and if related to disease severity. Soluble EGF-R, vitamin D, parathyroid hormone (PTH) was studied, and being evaluated in relation to Ca 2? , lipids, hsCRP, fibrinogen, serotonin, norepinepherine (NE). The study compared non-smoker, non-obese male CHF patients (n = 50) with age and gender-matched essential hypertension (HTN) patients (n = 20). Moreover, comparison with healthy control volunteers (n = 20) were employed. EGF-R/HER-1/erbB-1 was higher (P = 0.013) in 50 CHF male patients mean 12 ± 0.7 fmol/ml, than in 20 HTN, 9.25 ± 0.6 fmol/ml or in 20 controls, 6.25 ± 1 fmol/ml. Serum EGF-R levels correlated positively with hsCRP and NE, and were highest among CVD patients (n = 70) as well as negatively with vitamin D and HDL-C. EGF-R/HER-1/erbB-1 levels are increased in HTN and more in CHF patients. This study confirms a strong association between catecholamines as well as EGF-R/HER-1/ erbB-1 levels with PTH and low vitamin D levels, being related to hyperlipidemia and inflammation (hsCRP and fibrinogen) in CVD. Moreover, contributing to the complex process of the inflammatory component of atherosclerosis in hypertensive patients that leads eventually to CHF.

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Inflammatory and thrombotic mechanisms in coronary atherosclerosis

Cited by 133 publications

References 80 publications

Associação de níveis plasmáticos de PAI-1 e polimorfismo 4G/5G em pacientes com doença arterial coronariana

Associação de níveis plasmáticos de PAI-1 e polimorfismo 4G/5G em pacientes com doença arterial coronariana

Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

Involvement of Depressive Catecholamines as Thrombosis Risk/Inflammatory Markers in Non-Smoker, Non-Obese Congestive Heart Failure, Linked to Increased Epidermal Growth Factor-Receptor (EGF-R) Production

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