Inflammatory arthritis-associated pyoderma gangrenosum: a systematic review

Clinical guidance of pyoderma gangrenosum 2022

“…There have been multiple systematic reviews on the treatment for PG, and corticosteroids have been used most frequently, followed by cyclosporine. [136][137][138][139][140] Since these two drugs have their characteristic profiles, it is recommended to select either drug on a case-by-case basis. Although these drugs are effective for the initial treatment for PG, it takes a very long time (6 months) before cure; the development of more effective treatments is awaited.…”

“…However, these results suggest that cyclosporine can be a choice comparable to corticosteroids. There have been multiple systematic reviews on the treatment for PG, and corticosteroids have been used most frequently, followed by cyclosporine 136–140 . Since these two drugs have their characteristic profiles, it is recommended to select either drug on a case‐by‐case basis.…”

“…They also develop rash less frequently during treatment with anti‐TNF antibody preparations, azathioprine, or methotrexate 139 . It has been reported that many PG patients with rheumatoid arthritis or seronegative arthritis resist treatment with corticosteroids or cyclosporine, are often treated with drugs including anti‐TNF antibody preparations or anti‐IL‐1 preparations, and their prognosis is poor 140,143 . PG associated with hematological malignancies has been reported to be complicated most frequently by myelodysplastic syndrome, followed by monoclonal gammopathy with undetermined significance, and acute myelocytic leukemia 144 .…”

Pioderma gangrenoso asociado a artritis reumatoide

“…El PG puede ocurrir de forma aislada, como un síndrome inflamatorio hereditario, en asociación a una enfermedad sistémica, y con o sin manifestaciones extracutáneas. 9 Kridin y colaboradores publicaron en el 2018 un metaanálisis en el cual se reportó que 57% de los pacientes con PG tenían una enfermedad sistémica asociada, siendo las más frecuentes: enfermedad inflamatoria intestinal, artritis reumatoide y neoplasias malignas hematológicas. 10 Aproximadamente, 13% de los pacientes con PG tienen artritis inflamatoria, la más común es la artritis reumatoide (AR).…”

“…Además de la AR, se ha informado de PG en pacientes con espondiloartritis, como artritis psoriásica, espondilitis anquilosante y artritis asociada a enfermedad inflamatoria intestinal. 9 Sawka y colaboradores realizaron una revisión sistemática en donde el objetivo fue describir la asociación entre PG y AR. Consideraron 1,399 artículos, encontrando 129 pacientes con PG y artritis inflamatorias.…”