Inflammatory biomarkers differentiate the stage of maturation in chronic subdural hematomas

Wettervik, Teodor Svedung; Sundblom, Jimmy; Ronne-Engström, Elisabeth

doi:10.1016/j.jneuroim.2023.578127

Cited by 4 publications

(6 citation statements)

References 37 publications

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“…Accumulated evidence demonstrated that inflammation play an important role in the development and progression of CSDH ( Edlmann et al, 2017 ; Svedung Wettervik, Sundblom & Ronne-Engstrom, 2023 ). Anti-inflammatory drug therapy can dramatically reduce the growth and recurrence of CSDH in conservative and surgically treated patients with CSDH and was considered has potentially beneficial for CSDH patients ( Vychopen, Guresir & Wach, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Peptidomics insights: neutrophil extracellular traps (NETs) related to the chronic subdural hemorrhage

Li,

Zhao,

Sun

et al. 2023

PeerJ

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Chronic subdural hemorrhage (CSDH) refers to a hematoma with an envelope between the dura mater and the arachnoid membrane and is more common among the elderly. It was reported that the dura mater, which is highly vascularized with capillary beds, precapillary arterioles and postcapillary venules play an important role in the protection of the central nervous system (CNS). Numerous evidences suggests that peptides play an important role in neuroprotection of CNS. However, whether dura mater derived endogenous peptides participate in the pathogenesis of CSDH remains undetermined. In the current study, the peptidomic profiles were performed in human dura of CSDH (three patients) and the relative control group (three non-CSDH samples) by LC-MS (liquid chromatography–mass spectrometry). The results suggested that a total of 569 peptides were differentially expressed in the dura matter of CSDH compared with relative controls, including 217 up-regulated peptides and 352 down-regulated peptides. Gene Ontology (GO) analysis demonstrated that the precursor proteins of those differentially expressed peptides were involved in the various biological processes. Interestingly, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis suggested that NETs participated in the pathogenies of CSDH. Further investigate showed that H3Cit was significantly elevated in the dural and hematoma membranes of patients with CSDH compared to patients without CSDH. Taken together, our results showed the differentially expressed peptides in human dura mater of CSDH and demonstrated that NETs formation in the dural and hematoma membranes might be involved in the pathogenesis of CSDH. It is worth noting that pharmacological inhibition of NETs may have potential therapeutic implications for CSDH.

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Section: Discussionmentioning

confidence: 99%

Peptidomics insights: neutrophil extracellular traps (NETs) related to the chronic subdural hemorrhage

Li,

Zhao,

Sun

et al. 2023

PeerJ

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“…28 In addition to peripheral blood, validation indicators in hematoma fluid also have significant research significance. In Teodor et al's study, 29 GDNF, NT-3, and IL-8 showed significant differences in different classifications, with higher values in the trabecular type. 29 In addition, patients with mediastinum in the CSDH lesion area had higher levels of GDNF, MCP-3, NT-3, CXCL1, CXCL5, IL8, and OSM.…”

mentioning

confidence: 87%

“…In Teodor et al's study, 29 GDNF, NT-3, and IL-8 showed significant differences in different classifications, with higher values in the trabecular type. 29 In addition, patients with mediastinum in the CSDH lesion area had higher levels of GDNF, MCP-3, NT-3, CXCL1, CXCL5, IL8, and OSM. 29 There is no correlation between Markwalder grading and inflammatory biomarkers.…”

mentioning

confidence: 87%

“…29 In addition, patients with mediastinum in the CSDH lesion area had higher levels of GDNF, MCP-3, NT-3, CXCL1, CXCL5, IL8, and OSM. 29 There is no correlation between Markwalder grading and inflammatory biomarkers. 29 A systematic review and meta-analysis conducted by Huang et al revealed that burr hole craniostomy (BHC) had higher efficacy compared to minicraniotomy (MC) in reducing the rate of recurrence, the rate of reoperation, and the duration of surgery.…”

mentioning

confidence: 90%

“…29 There is no correlation between Markwalder grading and inflammatory biomarkers. 29 A systematic review and meta-analysis conducted by Huang et al revealed that burr hole craniostomy (BHC) had higher efficacy compared to minicraniotomy (MC) in reducing the rate of recurrence, the rate of reoperation, and the duration of surgery. 12 The duration of surgery was significantly shorter in the BHC group compared with the MC group.…”

mentioning

confidence: 99%

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A Linear Regression Equation for Predicting the Residual Volume of Chronic Subdural Hematoma 1 Week After Surgery

Yan,

Su,

et al. 2023

NDT

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The outcome of chronic subdural hematoma (CSDH) is influenced not only by the choice of treatment but also by various baseline characteristics. The main objective of this study is to identify the risk factors that can affect the prognosis of CSDH and develop a regression equation based on these risk factors. Methods: A total of 212 patients with CSDH were included in the study. We collected clinical data including age, gender, and so on, and radiological data including preoperative hematoma volume (V 1 ), effusion volume 1 day after surgery (V 2 ), gas volume 1 day after surgery (V 3 ), and so on. These were considered independent variables, while residual volume 1 week after surgery (V 4 ) was the dependent variable. Univariate linear regression analysis was performed to identify factors that were significantly related. Subsequently, multivariate linear regression analysis was conducted to determine the relationship between each independent variable and the dependent variable. Multiple linear regression analysis was used to obtain a regression equation predicting V 4 . Results: We have found that age (t = 3.109, P = 0.002), aspirin (t = 2.762, P = 0.006), hemostatic agents (haemocoagulase, t = 3.731, P < 0.001; vitamin K, t = 2.824, P = 0.005 < 0.05), V 2 (t = 8.73, P < 0.001), and V 3 (t = 5.968, P < 0.001) are significantly associated with V 4 . Furthermore, we have developed a regression equation that can predict this volume with CSDH. The fit of the model is robust with an R-squared value of 65.2% > 50%. Conclusion: Age, aspirin, hemostatic agent, V 2 , and V 3 are significantly associated with V 4. We developed a regression equation to predict this volume with CSDH.

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Methods and clinical biomarker discovery for targeted proteomics using Olink technology

Wang,

Zhao,

Zeng

et al. 2024

Proteomics Clinical Apps

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PurposeThis paper is to offer insights for designing research utilizing Olink technology to identify biomarkers and potential therapeutic targets for disease treatment.Experimental DesignWe discusses the application of Olink technology in oncology, cardiovascular, respiratory and immune‐related diseases, and Outlines the advantages and limitations of Olink technology.ResultsOlink technology simplifies the search for therapeutic targets, advances proteomics research, reveals the pathogenesis of diseases, and ultimately helps patients develop precision treatments.ConclusionsAlthough proteomics technology has been rapidly developed in recent years, each method has its own disadvantages, so in the future research, more methods should be selected for combined application to verify each other.

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Inflammatory biomarkers differentiate the stage of maturation in chronic subdural hematomas

Cited by 4 publications

References 37 publications

Peptidomics insights: neutrophil extracellular traps (NETs) related to the chronic subdural hemorrhage

Peptidomics insights: neutrophil extracellular traps (NETs) related to the chronic subdural hemorrhage

A Linear Regression Equation for Predicting the Residual Volume of Chronic Subdural Hematoma 1 Week After Surgery

Methods and clinical biomarker discovery for targeted proteomics using Olink technology

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