Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor

Park, Kyo Hoon; Lee, Kyong-No; Oh, Eunji; Im, Eun Mi

doi:10.1016/j.cyto.2023.156308

Cited by 4 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, there are ongoing studies on several other biomarkers which might help predict PTB [ 38 , 51 , 52 ]. First of all, inflammatory markers are analyzed, such as the proinflammatory interleukins of cytokines found in the maternal serum [ 51 ] or in cervical secretions [ 53 ]. The study by Laudanski et al showed that the levels of IGFBP-1, Eotaxin-1, BLC, BDNF, and MIP-1d measured in the serum might serve as predictive indicators for preterm labour.…”

Section: Discussionmentioning

confidence: 99%

Placental Cannabinoid Receptor Expression in Preterm Birth

Feduniw,

Krupa,

Łagowska

et al. 2024

Journal of Pregnancy

View full text Add to dashboard Cite

Background: The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a significant role in preterm birth (PTB). The aim of the study was to investigate the association between the expression of the CBR in the placenta and the incidence of PTB.Methods: This prospective, observational, multicentre preliminary study was conducted on placental samples obtained from 109 women. The study included 95 patients hospitalized due to the high risk of PTB. They were divided into two groups: Group 1, where the expression of the CBR1 and CBR1a was analyzed, and Group 2, in which we examined CBR2 expression. The control group, that is, Group 3, consisted of 14 women who delivered at term, and their placentas were tested for the presence of all three receptor types (CBR1, CBR1a, and CBR2).Results: The study used reverse transcription and real-time PCR methods to assess the expression of CBRs in the placental tissues. The expression of the CBR2, CBR1, and CBR1a receptors was significantly lower in the placentas of women after PTB compared to those after term births, p=0.038, 0.033, and 0.034, respectively.Conclusions: The presence of CBR mRNA in the human placental tissue was confirmed. The decreased expression of CBRs could serve as an indicator in predicting PTB.

show abstract

Section: Discussionmentioning

confidence: 99%

Placental Cannabinoid Receptor Expression in Preterm Birth

Feduniw,

Krupa,

Łagowska

et al. 2024

Journal of Pregnancy

View full text Add to dashboard Cite

show abstract

Absolute counts of leukocyte subsets in peripheral blood in pregnancies complicated by preterm prelabour rupture of membranes

Soucek,

Kacerovsky,

Kacerovska Musilova

et al. 2024

Journal of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Vaginal and Placental Microbiome in Pregnant and Laboring Women With Obesity and Gestational Diabetes Mellitus

Zhelezniakov,

Kudin,

Lazurenko

et al. 2024

Act. Probl. of the Modern Med.

View full text Add to dashboard Cite

Introduction. The microbiome of pregnant women has become a significant focus of scientific research. Understanding the vaginal and placental microbiome is particularly important in the pathogenesis of intrauterine infections, chorioamnionitis, and preterm birth. Therefore, studying the microbiota of the vagina, placenta, and amniotic fluid—key barriers against infectious agents—is crucial for reducing perinatal complications. This study aims to investigate the vaginal and placental microbiota in pregnant and laboring women with obesity and gestational diabetes mellitus, with the goal of reducing pregnancy complications and perinatal morbidity. Materials and Methods. The study was conducted in two stages. The first stage involved a bacteriological analysis of the vaginal microbiota in 1,794 pregnant women with clinical signs of colpitis, who were admitted to the Department of Pregnancy Pathology at the Regional Clinical Hospital for examination and subsequent delivery in 2023–2024. In the second stage, a bacteriological study of the vaginal and placental microbiota was carried out in 37 obese women in labor with gestational diabetes mellitus (GDM) (main group) and 20 pregnant women without somatic or obstetric pathology (control group). Results and Discussion. An analysis of the vaginal microbiota in 1,794 pregnant women with colpitis revealed the following distribution of pathogens: Enterococcus faecalis (627 cases, 34.9%), Candida albicans (510 cases, 28.4%), Escherichia coli (288 cases, 16.1%), Staphylococcus aureus (68 cases, 3.8%), Klebsiella pneumoniae (53 cases, 2.95%), Staphylococcus epidermidis (51 cases, 2.8%), Streptococcus agalactiae (46 cases, 2.6%), and Staphylococcus haemolyticus (41 cases, 2.3%). The frequency of all other bacteria was less than 1%. In the main group of pregnant women with GDM and obesity, who developed chorioamnionitis (29 cases, 78.4%), the vaginal microbiota revealed the following bacterial counts: Lactobacillus spp. at 5×1035 \times 10^35×103 CFU, Klebsiella pneumoniae at 10410^4104 CFU, Enterococcus faecalis at 10510^5105 CFU, and Candida albicans at 10710^7107 CFU. In the subgroup of women with intrauterine fetal infection (18 cases, 48.7%), Klebsiella pneumoniae was detected at 10510^5105 CFU. Regarding the placental microbiome in the main group, the most common pathogens were Enterococcus faecalis (32.4%), Escherichia coli (27.2%), Staphylococcus aureus (8.1%), Burkholderia cepacia (8.1%), Klebsiella pneumoniae (5.4%), Staphylococcus haemolyticus (5.4%), Candida albicans (2.7%), Enterobacter cloacae (2.7%), Staphylococcus epidermidis (2.7%), Streptococcus agalactiae (2.7%), and Streptococcus parasanguinis (2.7%). No bacteria were detected in the placental microbiota of the control group. Conclusions. The investigation of the vaginal and placental microbiomes in pregnant women with obesity and gestational diabetes mellitus reveals the extent of bacterial colonization and associated damage in these sites. This knowledge is essential for the timely detection and treatment of infectious lesions in both the mother and fetus, aiming to reduce perinatal complications. Importantly, the pathogens identified in the vaginal and placental microbiomes during chorioamnionitis and intrauterine fetal infection do not always coincide, emphasizing the need for further research in this field.

show abstract

Inflammatory biomarkers in the cervicovaginal fluid to identify histologic chorioamnionitis and funisitis in women with preterm labor

Cited by 4 publications

References 60 publications

Placental Cannabinoid Receptor Expression in Preterm Birth

Placental Cannabinoid Receptor Expression in Preterm Birth

Absolute counts of leukocyte subsets in peripheral blood in pregnancies complicated by preterm prelabour rupture of membranes

Vaginal and Placental Microbiome in Pregnant and Laboring Women With Obesity and Gestational Diabetes Mellitus

Contact Info

Product

Resources

About