Inflammatory Bowel Disease

Parian, Alyssa; Mullin, Gerard E.; Langhorst, Jost; Brown, Amy C.

doi:10.1016/b978-0-323-35868-2.00050-5

Cited by 9 publications

(11 citation statements)

References 333 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When they do, doses are significantly different between studies. One of the most referred and quantified components is curcumin, although the lack of consensus on the ideal dosing is evident [ 1 , 35 ]. In this study, a 2 g/day dose was used, the same as Hanai et al, who associated this intake together with 5-ASA to higher efficiency in maintaining UC remission when compared with placebo and 5-ASA.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory bowel disease (IBD) is characterized by a chronic inflammatory process of the gastrointestinal tract and is marked by a disruption of the intestinal barrier that influences intestinal permeability (IP). Although its pathogenesis is not fully understood, recent evidence suggests that IBD is associated with a multifactorial process involving genetics, environmental factors, microbiota, and deregulation of the immune system [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Different in vitro studies have previously evaluated the effect of specific food components on IP by measuring the transepithelial electric resistance that measures the ion flux between cells [ 7 , 8 ]. Components having a positive effect include polyphenols (quercetin and curcumin), tryptophan, zinc, vitamin D, prebiotics (beta-glucans and butyrate) and glutamine [ 1 , 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. These components revealed a protective role on the integrity of TJP from the intestinal barrier, thereby reducing its permeability: Curcumin and quercetin are two polyphenols that occur in nature and can influence the intestinal barrier structure.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional Food Components, Intestinal Permeability and Inflammatory Markers in Patients with Inflammatory Bowel Disease

et al. 2021

View full text Add to dashboard Cite

Inflammatory bowel diseases (IBD) are characterized by a chronic inflammatory process that affects the intestinal barrier structure. Recent evidence suggests that some food components can influence the integrity of the intestinal barrier and thus its permeability. We aimed at assessing the effect of food components on the intestinal permeability (IP) and on inflammatory markers in individuals with IBD by a single-blind randomized clinical study. Of the 53 individuals included, 47% (n = 25) had been diagnosed with IBD. The participants were divided into 4 groups. IBD patients were allocated to intervention group (n = 14) vs. no intervention group (n = 11), and the same happened with 28 control participants without disease (n = 14 in intervention group vs. n = 14 without intervention). Symptomatology, nutritional status, biochemical parameters (specifically serum zonulin (ZO) to measure IP) were evaluated on all individuals on an eight week period following a diet plan with/without potentially beneficial foods for the IP. At the beginning of the study, there were no significant differences in ZO values between individuals with and without IBD (p > 0.05). The effect of specific food components was inconclusive; however, a trend in the reduction of inflammatory parameters and on the prevalence of gastrointestinal symptomatology was observed. More controlled intervention studies with diet plans, including food components potentially beneficial for the integrity of the intestinal barrier, are of the utmost importance.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional Food Components, Intestinal Permeability and Inflammatory Markers in Patients with Inflammatory Bowel Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Retinol, the most active form, is an important chain-breaking antioxidant, involved in scavenging superoxide and hydroxyl radicals [94]. It is known for its essential role in cellular differentiation, vision [95] and wound healing, and its deficiency in the human body has been associated with multiple pathological conditions, such as inflammatory bowel disease [96]. While vitamin A activity is not mainly involved in the antioxidative mechanisms of the brain, one study demonstrated its neuroprotective effects against amyloid fibrillation-associated cytotoxicity.…”

Section: Antioxidants For Neuroprotectionmentioning

confidence: 99%

“…Vitamin C, also known as ascorbic acid, is an essential water-soluble antioxidant that performs many important functions in the body [96,105]. It is considered as an ideal antioxidant as it is characterized by a low reduction potential that allows for its reaction with various ROS [106].…”

Section: Antioxidants For Neuroprotectionmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

View full text Add to dashboard Cite

Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

show abstract

Gut microbiome and neurosurgery: Implications for treatment

Willman

Reddy

et al. 2022

Clinical and Translational Dis

View full text Add to dashboard Cite

Introduction: The aim of this review is to summarize the current understanding of the gut-brain axis (GBA), its impact on neurosurgery, and its implications for future treatment. Background: An abundance of research has established the existence of a collection of pathways between the gut microbiome and the central nervous system (CNS), commonly known as the GBA. Complicating this relationship, the gut microbiome bacterial diversity appears to change with age, antibiotic exposure and a number of external and internal factors. Methods: In this paper, we present the current understanding of the key protective and deleterious roles the gut microbiome plays in the pathogenesis of several common neurosurgical concerns. Results: Specifically, we examine how spinal cord injury, traumatic brain injury and stroke may cause gut microbial dysbiosis. Furthermore, this link appears to be bidirectional as gut dysbiosis contributes to secondary CNS injury in each of these ailment settings. This toxic cycle may be broken, and the future secondary damage rescued by timely, therapeutic, gut microbiome modification. In addition, a robust gut microbiome appears to improve outcomes in brain tumour treatment. There are several primary routes by which microbiome dysbiosis may be ameliorated, including faecal microbiota transplant, oral probiotics, bacteriophages, genetic modification of gut microbiota and vagus nerve stimulation. Conclusion: The GBA represents an important component of patient care in the field of neurosurgery. Future research may illuminate ideal methods of therapeutic microbiome modulation in distinct pathogenic settings.

show abstract

Inflammatory Bowel Disease

Cited by 9 publications

References 333 publications

Functional Food Components, Intestinal Permeability and Inflammatory Markers in Patients with Inflammatory Bowel Disease

Functional Food Components, Intestinal Permeability and Inflammatory Markers in Patients with Inflammatory Bowel Disease

Antioxidant Therapies for Neuroprotection—A Review

Gut microbiome and neurosurgery: Implications for treatment

Contact Info

Product

Resources

About