Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique

Tan, Mingyue; Wang, Yunqing; Ji, Yunxia; Mei, Rongchao; Zhao, Xizhen; Song, Jie; You, Jinmao; Chen, Lingxin; Wang, Xiaoyan

doi:10.1016/j.talanta.2024.126172

Talanta

2024

DOI: 10.1016/j.talanta.2024.126172

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Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique

Mingyue Tan,

Yunqing Wang,

Yunxia Ji

et al.

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2024

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Cited by 2 publications

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Advances in research on the role of high carbohydrate diet in the process of inflammatory bowel disease (IBD)

Zhang,

Xun,

Qiao

et al. 2024

Front. Immunol.

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Inflammatory bowel disease (IBD) is a chronic, systemic gastrointestinal disorder characterized by episodic inflammation that requires life-long management. Although the etiology of IBD is not fully understood, it is hypothesized to involve a multifaceted interplay among genetic susceptibility, the host immune response, and environmental factors. Previous studies have largely concluded that IBD is associated with this complex interplay; however, more recent evidence underscores the significant role of dietary habits as risk factors for the development of IBD. In this review, we review the molecular mechanisms of high-sugar and high-fat diets in the progression of IBD and specifically address the impacts of these diets on the gut microbiome, immune system regulation, and integrity of the intestinal barrier, thereby highlighting their roles in the pathogenesis and exacerbation of IBD.

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Advances in research on the role of high carbohydrate diet in the process of inflammatory bowel disease (IBD)

Zhang,

Xun,

Qiao

et al. 2024

Front. Immunol.

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Nanoparticle Uptake in the Aging and Oncogenic Drosophila Midgut Measured with Surface-Enhanced Raman Spectroscopy

Christou,

Fidelix,

Apidianakis

et al. 2024

Cells

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Colorectal cancer remains a major global health concern. Colonoscopy, the gold-standard colorectal cancer diagnostic, relies on the visual detection of lesions and necessitates invasive biopsies for confirmation. Alternative diagnostic methods, based on nanomedicine, can facilitate early detection of malignancies. Here, we examine the uptake of surface-enhanced Raman scattering nanoparticles (SERS NPs) as a marker for intestinal tumor detection and imaging using an established Drosophila melanogaster model for gut disease. Young and old Oregon-R and w1118 flies were orally administered SERS NPs and scanned without and upon gut lumen clearance to assess nanoparticle retention as a function of aging. Neither young nor old flies showed significant NP retention in their body after gut lumen clearance. Moreover, tumorigenic flies of the esg-Gal4/UAS-RasV12 genotype were tested for SERS NP retention 2, 4 and 6 days after RasV12 oncogene induction in their midgut progenitor cells. Tumorigenic flies showed a statistically significant NP retention signal at 2 days, well before midgut epithelium impairment. The signal was then visualized in scans of dissected guts revealing areas of NP uptake in the posterior midgut region of high stem cell activity.

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Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique

Cited by 2 publications

References 58 publications

Advances in research on the role of high carbohydrate diet in the process of inflammatory bowel disease (IBD)

Advances in research on the role of high carbohydrate diet in the process of inflammatory bowel disease (IBD)

Nanoparticle Uptake in the Aging and Oncogenic Drosophila Midgut Measured with Surface-Enhanced Raman Spectroscopy

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