Inflammatory bowel disease and airway diseases

Vutcovici, Maria; Brassard, Paul; Bitton, Alain

doi:10.3748/wjg.v22.i34.7735

Cited by 52 publications

(51 citation statements)

References 82 publications

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“…Concurrently, the risk of new-onset IBD is found to be higher in populations with obstructive pulmonary diseases such as obstructive pulmonary disease (COPD), asthma, and bronchiectasis compared to the general population without these conditions [6,7,8]. This newly documented evidence of IBD incidence among patients with pulmonary diseases and the higher than the estimated prevalence of pulmonary conditions among IBD patients support the hypothesis of a two-way association [5].…”

Section: Introductionmentioning

confidence: 59%

“…Patients with IBD are at an elevated risk of autoimmune and inflammatory conditions [4]. Airway diseases are one of the most commonly studied manifestations of IBD [5]. Concurrently, the risk of new-onset IBD is found to be higher in populations with obstructive pulmonary diseases such as obstructive pulmonary disease (COPD), asthma, and bronchiectasis compared to the general population without these conditions [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Zergham

Sekhon

Mebasher

et al. 2020

Cureus

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Inflammatory bowel diseases (IBD) is an umbrella term that covers both ulcerative colitis (UC) and Crohn's disease (CD), which are chronic inflammatory conditions of the gastrointestinal system. Airway diseases are one of the most commonly studied manifestations of IBD. It is observed that populations with pre-existing obstructive pulmonary conditions are at higher risk of new-onset IBD. This newly documented evidence of increased incidence of IBD among patients with pulmonary diseases and the higher than the estimated prevalence of pulmonary diseases among IBD sufferers support the hypothesis of a two-way association. This review article focuses on summarizing the current knowledge and available evidence regarding the association between IBD and obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), emphysema, bronchiectasis, and asthma.We utilized PubMed as the primary search source and database and included the free full-text articles available on it, published over the past five years. We reviewed literature from multiple regions of the world, such as the US, UK, China, and Canada and compiled this traditional review article utilizing the information collected from 4,966,459 patients. Specifications such as age and gender were not mentioned in all articles. This review will serve to strengthen the existing research database concerning the relationship between IBD and obstructive pulmonary diseases. It will help to highlight the significance of the two-way association between IBD and obstructive pulmonary disease and the importance of treating these two conditions simultaneously. It will also raise awareness about the importance of timely detection of IBD and associated airway complications, leading to decreased disease burden and the treatment cost.

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Section: Introductionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Zergham

Sekhon

Mebasher

et al. 2020

Cureus

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“…PFTs might be used as a noninvasive means of diagnosis to determine the activity of disease and might contribute to the early detection of latent pulmonary involvement [36]. On the other hand, there is a new growing evidence of an inter-relation between IBD and airway diseases that not only airway diseases occur as extra intestinal manifestations of IBD, but also there's relative risk increase of IBD occurrence among patients with pulmonary airway diseases as asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis, Future research should be carried out for further exploration of this tow-way association [33]. There is a retrospective cohort study conducted by Paul Brassard in 2014 to assess whether the incidences of Crohn's disease and ulcerative colitis are increased in patients with asthma and chronic obstructive pulmonary disease (COPD) compared to the general population during 2001-2006, they found that the incidences of both Crohn's disease and ulcerative colitis were markedly increased in asthma and COPD patients during 2001-2006 compared to the general population of Québec.…”

Section: Incidence Yearmentioning

confidence: 99%

“…Episcleritis [25] Scleritis [25] Uveitis Incidence of the pulmonary complication reported as relatively rare extra intestinal manifestation of Crohn's disease; 21% to 41% of patients with IBD patients had pulmonary complications and are more common in Crohn's disease (CD) than in ulcerative colitis (UC), 400 cases with CD has been recognized and reported in the literature with pulmonary involvement [32][33][34][35][36][37], it's occasionally possibly causing serious illness that needs pulmonary evaluation, a wide spectrum of lung manifestations , extending from subclinical changes without any symptoms, upper and lower airway diseases, parenchymal diseases of lung up to pleural involvement in addition to medication side effects. The most obvious complication is bronchial inflammation and suppuration with or without bronchiectasis.…”

Section: Incidence Yearmentioning

confidence: 99%

Extra-Intestinal Complications (EIC) and Manifestations (EIM) (Ocular and Pulmonary) among Patients with Crohn's Disease

Ali¹,

Bamahfouz²,

Krema³

et al. 2017

J Gastrointest Dig Syst

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Crohn's disease (CD) is an immune-mediated disorder of unknown etiology primarily affect the gastrointestinal tract with series of extra intestinal manifestations (EIM) and Extra intestinal complications (EIC) that affects different organs and systems. EIMs are capable of involving nearly every system in the body; some believe that IBD is a systemic disorder with predominantly bowel manifestations. EI complications are mainly caused by the disease itself that induce mal-absorption with consequent micronutrient deficiencies, osteoporosis, peripheral neuropathies, kidney stones, gallstones and IBD drug-related side effects. In Saudi Arabia, CD is reported frequently. In this review, we try to make stress on different previously reported frequencies of EIMs and EIC in patients with CD; from our point of view we make an overview on the ocular and pulmonary complications and manifestations that are related either to disease activity or an indication of the presence of CD. Scleritis, uveitis and dry eye syndrome in previous healthy subjects with intestinal manifestation help in early diagnosis of CD especially in unexpected ages of the diseases. Further work on pulmonary manifestations to make full explanation on whether pulmonary disease is secondary to the drugs or to the underlying disease process.

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“…However, the similarities in disease pathogenesis and the sharing of important environmental risk factors and genetic susceptibility suggest that there is a complex interplay between IBD and airway diseases 85 .…”

mentioning

confidence: 99%

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

Beghè¹,

Clini²,

Fabbri³

2017

BRN

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Two-thirds of people aged ≥65 years have multi-morbidity. Multi-morbidity includes both physical and mental health conditions, as anxiety and depression, that almost invariably affect patients with multiple symptomatic chronic diseases. Management of a patient with any of the chronic diseases that are part of multi-morbidity is not just the management of that single index disease, but must include the active search and proper treatment of concomitant chronic diseases. The presence of concomitant chronic diseases should not alter the management of the index disease (e.g., chronic obstructive pulmonary disease [COPD]), and concomitant chronic diseases should be treated according to single diseases guidelines regardless of the presence of the index disease, obviously with careful consideration that this choice implies complex management, polypharmacy and potential adverse effects. Preliminary management programs suggest that a holistic integrated approach might improve quality of life and reduce hospital admissions and death in these multimorbid patients. (BRN Rev. 2017;3:247-66)

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Inflammatory bowel disease and airway diseases

Cited by 52 publications

References 82 publications

Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Extra-Intestinal Complications (EIC) and Manifestations (EIM) (Ocular and Pulmonary) among Patients with Crohn's Disease

Chronic Respiratory Abnormalities in the Multi-Morbid Frail Elderly

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