Inflammatory Bowel Disease and Cardiovascular Diseases

Chen, Bing; Collen, Lauren; Mowat, Craig; Isaacs, Kim L.; Singh, Siddharth; Kane, Sunanda V.; Loftus, Edward V.; Farraye, Francis A.; Snapper, Scott B.; Jneid, Hani; Lavie, Carl J.; Krittanawong, Chayakrit

doi:10.1016/j.amjmed.2022.08.012

Cited by 39 publications

(27 citation statements)

References 49 publications

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“…This is despite the fact that there is sufficient evidence to support a plant-based dietary approach alongside conventional pharmaceutical treatment. In addition, dietary counselling is relevant in supporting better overall health in people living with IBD who have a significantly increased risk of cardiovascular disease, 29,30 type 2 diabetes 31,32 and certain cancers, 33 when compared to the general population. A healthy diet alongside other healthy lifestyle behaviours has the ability to significantly reduce mortality in people with IBD.…”

Section: Discussionmentioning

confidence: 99%

A Whole Food Plant-Based Approach to Ulcerative Colitis; A Case Series

Marselou,

Kassam

2023

American Journal of Lifestyle Medicine

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Inflammatory bowel disease (IBD) is a relapsing and remitting condition that requires continuous treatment to reduce the risk of relapse. Alongside genetic factors, diet and lifestyle factors are heavily implicated in the pathogenesis of the disease, with diets high in meat and ultra-processed foods and low in fibre-rich plant foods thought to be central to the disease process. There is considerable interest in using dietary interventions to prevent, treat and IBD, with the hope that this can limit and, in some cases, even eliminate the use of pharmaceutical interventions. A whole food plant-based diet (WFPBD) is an attractive option given its emphasis on foods that promote gut health and reduce inflammation and the avoidance of foods that are associated with dysbiosis and inflammation. Here we describe 3 case histories of patients with ulcerative colitis and the successful use of a WFPBD for remission induction and maintenance with over 2 years of follow-up.

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Section: Discussionmentioning

confidence: 99%

A Whole Food Plant-Based Approach to Ulcerative Colitis; A Case Series

Marselou,

Kassam

2023

American Journal of Lifestyle Medicine

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“…28,29 Additionally, smoking, diabetes, dysbiosis of gut microbiota and systematic inflammation were considered shared risk factors for atherosclerotic cardiovascular disease and IBD. 30 Most previous studies only focused on the comparison of CAD or AMI versus healthy populations, but investigation for biomarkers that play a crucial role in the progression of CAD proceeding to AMI is limited, especially in IBD patients. Herein, by adopting multiple machine-learning algorithms and bioinformatics strategy, the paper aims to explore potential biomarkers for predicting the CAD progression in patients with IBD and assess immune alterations, providing reference for future prevention and treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Both IBD and CAD were involved in the innate immune pathways mediated by toll like receptors, 27 as well as adaptive immunity maintained by elevated inflammatory T cell infiltration 28,29 . Additionally, smoking, diabetes, dysbiosis of gut microbiota and systematic inflammation were considered shared risk factors for atherosclerotic cardiovascular disease and IBD 30 …”

Section: Introductionmentioning

confidence: 99%

Identification of key biomarkers for predicting CAD progression in inflammatory bowel disease via machine‐learning and bioinformatics strategies

Tang,

Zhou,

Chen

et al. 2024

J Cellular Molecular Medi

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The study aimed to identify the biomarkers for predicting coronary atherosclerotic lesions progression in patients with inflammatory bowel disease (IBD). Related transcriptome datasets were seized from Gene Expression Omnibus database. IBD‐related modules were identified via Weighted Gene Co‐expression Network Analysis. The ‘Limma’ was applied to screen differentially expressed genes between stable coronary artery disease (CAD) and acute myocardial infarction (AMI). Subsequently, we employed protein‐protein interaction (PPI) network and three machine‐learning strategies to further screen for candidate hub genes. Application of the receiver operating characteristics curve to quantitatively evaluate candidates to determine key diagnostic biomarkers, followed by a nomogram construction. Ultimately, we performed immune landscape analysis, single‐gene GSEA and prediction of target‐drugs. 3227 IBD‐related module genes and 570 DEGs accounting for AMI were recognized. Intersection yielded 85 shared genes and mostly enriched in immune and inflammatory pathways. After filtering through PPI network and multi‐machine learning algorithms, five candidate genes generated. Upon validation, CTSD, CEBPD, CYP27A1 were identified as key diagnostic biomarkers with a superior sensitivity and specificity (AUC > 0.8). Furthermore, all three genes were negatively correlated with CD4+ T cells and positively correlated with neutrophils. Single‐gene GSEA highlighted the importance of pathogen invasion, metabolism, immune and inflammation responses during the pathogenesis of AMI. Ten target‐drugs were predicted. The discovery of three peripheral blood biomarkers capable of predicting the risk of CAD proceeding into AMI in IBD patients. These identified biomarkers were negatively correlated with CD4+ T cells and positively correlated with neutrophils, indicating a latent therapeutic target.

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“…Inflammation, carotid subclinical atherosclerosis [ 1 ], and insulin resistance [ 2 ], parameters that are all associated with cardiovascular (CV) disease, are increased in IBD. Accordingly, IBD has been associated with an increased risk of atherosclerotic CV disease, heart failure, and atrial fibrillation [ 3 ]. In addition, IBD is also associated with a state of inflammatory dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Lipoprotein Lipase Are Increased in Patients with Inflammatory Bowel Disease

Rodríguez-Hernández

Carrillo-Palau

Camba

et al. 2023

IJMS

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Disruption of the lipid profile is commonly found in patients with inflammatory bowel disease (IBD). Lipoprotein lipase (LPL) is a key molecule involved in triglyceride metabolism that plays a significant role in the progression of atherosclerosis. In this study, our aim was to study whether serum LPL levels are different in IBD patients and controls and whether IBD features are related to LPL. This was a cross-sectional study that encompassed 405 individuals; 197 IBD patients with a median disease duration of 12 years and 208 age- and sex-matched controls. LPL levels and a complete lipid profile were assessed in all individuals. A multivariable analysis was performed to determine whether LPL serum levels were altered in IBD and to study their relationship with IBD characteristics. After the fully multivariable analysis, including cardiovascular risk factors and the changes in lipid profile that the disease causes itself, patients with IBD showed significantly higher levels of circulating LPL (beta coefficient 196 (95% confidence interval from 113 to 259) ng/mL, p < 0.001). LPL serum levels did not differ between Crohn’s disease and ulcerative colitis. However, serum C-reactive protein levels, disease duration, and the presence of an ileocolonic Crohn’s disease phenotype were found to be significantly and independently positively related to LPL. In contrast, LPL was not associated with subclinical carotid atherosclerosis. In conclusion, serum LPL levels were independently upregulated in patients with IBD. Inflammatory markers, disease duration and disease phenotype were responsible for this upregulation.

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Inflammatory Bowel Disease and Cardiovascular Diseases

Cited by 39 publications

References 49 publications

A Whole Food Plant-Based Approach to Ulcerative Colitis; A Case Series

A Whole Food Plant-Based Approach to Ulcerative Colitis; A Case Series

Identification of key biomarkers for predicting CAD progression in inflammatory bowel disease via machine‐learning and bioinformatics strategies

Serum Levels of Lipoprotein Lipase Are Increased in Patients with Inflammatory Bowel Disease

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