Inflammatory bowel disease and spondylarthropathy

Smale, Simon; Natt, R. S.; Orchard, Timothy R.; Russell, Anthony S.; Bjarnason, Ingvar

doi:10.1002/1529-0131(200112)44:12<2728::aid-art459>3.0.co;2-8

Cited by 98 publications

(53 citation statements)

References 69 publications

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“…Even though in AS some Authors reported a frequency of discovertebral erosions in a range of 1.5-28% (22,23), in EA our research group has recently found a high prevalence of this lesion (30.55%), confirming that they are an important characteristic aspect of all SpA. In particular, we found a high prevalence in patients with axial and peripheral subset (31.82%), suggesting that spondylodiscitis could be a characterizing feature of the overlap subset, type 3 axial and peripheral forms (16). Furthermore, in contrast with what was reported for AS (22) and PsA (24), the occurrence of these lesions in patients with UC and CD was earlier and often asymptomatic.…”

Section: Articular Manifestationssupporting

confidence: 82%

Articular and other Immune-Mediated Extra-Intestinal Manifestations in Inflammatory Bowel Diseases

et al. 2014

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The articular involvement in patients with inflammatory bowel diseases is included in the group of immune-mediated extra-intestinal manifestations, occurring approximately in a range from 6.2–36% of the patients. This group is also made up of the skin and eyes manifestations, that usually but not invariably are correlated with intestinal inflammatory disease activity. Rheumatic manifestations are the most frequent extra-intestinal findings of this group with a prevalence from 20–50%. They are divided into two different clinical subsets: peripheral and axial joint involvement (including sacroiliitis with or without spondylitis). Peripheral arthritis is the most frequent finding in both Crohn's disease and ulcerative colitis, occurring with a frequency ranging from 17–20%, and it is more common in Crohn's disease. Axial involvement is more common in Crohn's disease (5–22%) than in ulcerative colitis (2–6%) and generally the prevalence of sacroiliitis (asymptomatic and symptomatic) is between 12–20% and of spondylitis is between 2–16%. The IBD is also associated with other rheumatic diseases such as rheumatoid arthritis, Sjogren syndrome, Takayasu arteritis and fibromyalgia. The management of patients with EA requires an active cooperation between gastroenterologists and rheumatologists.

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Section: Articular Manifestationssupporting

confidence: 82%

Articular and other Immune-Mediated Extra-Intestinal Manifestations in Inflammatory Bowel Diseases

et al. 2014

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“…Both ulcerative colitis and Crohn disease (1,2 ) can be complicated by seronegative spondyloarthropathies, including two principal patterns of arthritis: spondylitis and peripheral arthritis. Spondyloarthropathies resembling idiopathic ankylosing spondylitis occur in 10% of patients with ulcerative colitis and, less frequently, in those with Crohn disease; peripheral, often asymmetric, arthropathies occur in 5-20% of IBD patients.…”

Section: Ykl-40 As a Marker Of Joint Involvement Inmentioning

confidence: 99%

“…Al- Very few reference intervals for salivary steroids in children have been established to date (1 ). Even the manufacturers of salivary steroid assays do not provide sufficient reference data for their products.…”

Section: Ykl-40 As a Marker Of Joint Involvement Inmentioning

confidence: 99%

YKL-40 as a Marker of Joint Involvement in Inflammatory Bowel Disease

et al. 2003

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“…O primeiro seria uma forma de artrite periférica chamada artrite enteropática. O segundo padrão, denominado axial, seria a sacroiliíte com ou sem espondilite (24,(42)(43)(44) . Além disso, podem ocorrer manifestações periarticulares como entesite, tendinite e periostite.…”

Section: Introductionunclassified

“…Outros autores descreveram a existência de sinovite granulomatosa (47,48) . Em geral, o curso clínico da artrite periférica é autolimitado, não evoluindo com destruição articular, e tende a ser recorrente de acordo com os períodos de exacerbação da atividade clínica da doença intestinal (2,22,24,26,42,43) . As articulações mais comumente afetadas no tipo de artrite sem espondilite são os joelhos e os tornozelos (18, 20-22, 24, 26, 28-30, 42) .…”

Section: Introductionunclassified

Manifestações articulares em pacientes com doença de Crohn e retocolite ulcerativa

Lanna¹,

Ferrari²,

Carvalho³

et al. 2006

Rev. Bras. Reumatol.

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RESUMOOs sintomas articulares constituem a manifestação extra-intestinal mais comum em pacientes com doença de Crohn e com retocolite ulcerativa. Reconhecida como artrite colítica, e mais recentemente, artrite enteropática, está classificada como uma das doenças do grupo das espondiloartropatias. Reconhecidamente, há dois padrões de acometimento articular: 1) periférico, habitualmente, associado aos períodos de atividade da doença intestinal e sem associação com o antígeno HLA B27, e 2) axial, caracterizado por espondilite e sacroiliíte, com curso clínico e radiográfico independente da doença intestinal e associado ao HLA B27. Palavras ABSTRACTJoint involvement is the most commom extraintestinal manifestation in patients with Crohn's disease and ulcerative colitis. The colitic arthritis, lately called enteropathic arthritis, is classified as one of the diseases of the spondyloarthropathies group. There are two patterns of joint involvement: 1) peripheral arthritis, usually coincides with exacerbations of the inflammatory bowel disease and is not associated with the HLA B27 antigen; and 2) axial involvement, characterized by spondylitis and sacroiliitis, which the clinical course is independent of the intestinal disease, and has an association with HLA B27.Keywords: ar thritis, inflammator y bowel disease, spondyloarthropathy, Crohn's disease, ulcerative colitis. INTRODUÇÃONa sua conceituação mais ampla, a doença inflamatória intestinal (DII) corresponde a qualquer processo inflamatório envolvendo o trato gastrintestinal, seja ele agudo ou crônico. A doença de Crohn (DC) e a retocolite ulcerativa (RCU) representam as duas principais formas de apresentação da DII, de causa desconhecida (1) . A despeito de constituírem doenças distintas, compartilham aspectos clínicos e epidemiológicos, sugerindo a possibilidade de fatores etiológicos comuns. O curso clínico, cujas manifestações principais são diarréia, dor abdominal e sangramento retal, caracteriza-se por períodos de remissão e exacerbação, e apresenta complicações as mais diversas. Associam-se, com certa freqüência, manifestações extra-intestinais tais como articulares, cutâneas, oculares, hepatobiliares e vasculares, que podem preceder, acompanhar ou suceder a doença intestinal. A etiopatogenia da DII é multifatorial, com a participação de fatores genéticos, intraluminais, alterações na barreira do epitélio intestinal e resposta imunológica anormal da mucosa. Estes fenômenos determinam a ativação da cascata imunoinflamatória, que resulta em lesão continuada da mucosa do intestino (2,3) . Os sintomas articulares constituem a manifestação extra-intestinal mais comum em pacientes com RCU e DC. Apesar do conhecimento da existência de uma poliartrite em associação às duas enfermidades por décadas, até 1959, acreditava-se que isto refletia a co-existência delas com a artrite reumatóide(AR) (4) . Nesta época, o quadro ficou mais bem definido, quando Wright e Watkinson (5) , estudando 108 pacientes com RCU, identificaram em 15,7% deles um tipo de artrite com caracterí...

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Inflammatory bowel disease and spondylarthropathy

Cited by 98 publications

References 69 publications

Articular and other Immune-Mediated Extra-Intestinal Manifestations in Inflammatory Bowel Diseases

Articular and other Immune-Mediated Extra-Intestinal Manifestations in Inflammatory Bowel Diseases

YKL-40 as a Marker of Joint Involvement in Inflammatory Bowel Disease

Manifestações articulares em pacientes com doença de Crohn e retocolite ulcerativa

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