Inflammatory Bowel Disease and the Risk of Erectile Dysfunction

Lai, Shih‐Wei; Kuo, Yu‐Hung; Fang, Chia-Wei; Liao, Kuan‐Fu

doi:10.1093/ibd/izz237

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…The calculated attributable risk arising from inflammatory bowel disease amounted to 0.022 ( Friedman et al, 2018 ). Furthermore, another study from the Taiwan National Health Insurance Program involving 23 million participants showed that the prevalence of ED was 1.65 times higher in men aged 20 years or older with inflammatory bowel disease compared to those without the condition ( Lai et al, 2019 ). In addition, Kao et al performed a prospective cohort study to investigate the correlation between inflammatory bowel disease and ED, and they revealed the risk of developing ED in inflammatory bowel disease individuals was 1.64-fold that of the non-inflammatory bowel disease controls ( Kao et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic liability to inflammatory bowel disease is causally associated with increased risk of erectile dysfunction: Evidence from a bidirectional Mendelian randomization study

Pan,

Sun,

Zheng

et al. 2024

Front. Genet.

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Background: Several observational cohort studies suggested a close correlation between inflammatory bowel disease and erectile dysfunction. Nevertheless, whether there was a causal effect between them remained debatable. In this study, we aimed to detect the underlying causal links between genetically predicted inflammatory bowel disease and the risk of erectile dysfunction.Methods: A bidirectional Mendelian randomization (MR) study was performed to assess the causal link between inflammatory bowel disease and erectile dysfunction. Inverse variance weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode were utilized to estimate the causality. The top single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease cases (n = 25,800) and erectile dysfunction cases (n = 1,154) were extracted from the summary genome-wide association study (GWAS) data obtained from a publicly attainable database. MR-PRESSO global outlier test and MR-Egger regression were utilized to explore the horizontal pleiotropy and outlier instrumental variables. Cochran’s Q statistic was utilized to detect the heterogeneity.Results: In the forward MR study, the IVW approach demonstrated that genetically determined inflammatory bowel disease exhibited a suggestively causal association with an increased risk of erectile dysfunction (OR: 1.11, 95% CI: 1.02–1.21, p = 0.019), and also the genetically determined Crohn’s disease was found to be causally associated with an increased risk of erectile dysfunction (OR: 1.09, 95% CI: 1.02–1.17, p = 0.014). However, the MR analysis results showed no significant evidence supporting a causal effect of ulcerative colitis with erectile dysfunction (OR: 1.02, 95% CI: 0.92–1.14, p = 0.679). Furthermore, the reverse MR analysis showed no causal effects of genetically determined erectile dysfunction on inflammatory bowel disease. Additionally, sensitivity analysis demonstrated no pleiotropy and heterogeneity.Conclusion: Our MR analysis substantiated causal links of inflammatory bowel disease and Crohn’s disease on erectile dysfunction, which may further elucidate how inflammatory bowel disease impacted the initiation and development of erectile dysfunction, and facilitated the prevention and clinical management of inflammatory bowel disease in individuals with erectile dysfunction.

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Section: Discussionmentioning

confidence: 99%

Genetic liability to inflammatory bowel disease is causally associated with increased risk of erectile dysfunction: Evidence from a bidirectional Mendelian randomization study

Pan,

Sun,

Zheng

et al. 2024

Front. Genet.

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“…The results of the quality assessment of the included studies were presented in Tables S1-S3. Two studies (24,26) were considered high quality, eight (25,(28)(29)(30)(31)(32)(33)(34) were considered moderate quality, and one (27) were considered low quality due to the lack of information about potential confounders and follow-up years.…”

Section: Study Qualitymentioning

confidence: 99%

Inflammatory bowel disease is associated with worse sexual function: a systematic review and meta-analysis

Chen¹,

Zhou²,

Song³

et al. 2022

Transl Androl Urol

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Background: Several studies report that sexuality is often affected by inflammatory bowel diseases (IBD).The aim of this meta-analysis was to investigate the association between IBD and sexual function.Methods: A literature search was conducted in PubMed, Web of Science, and EMBASE databases (up to September 1, 2020). Scores of sexual functions with a standard deviation and odds ratio (OR) or relative risk (RR) with a 95% CI were used to analysis the association between IBD and sexual function.Results: Eleven studies with 7,018 male IBD cases and 1,803 female IBD cases were included in the meta-analysis. In male individuals, the pooled results revealed that IBD was significantly associated with impaired erectile function and poor sexual satisfaction (RR for erectile function =1.50, 95% CI: 1.22 to 1.84, P<0.0001; standard mean difference for sexual satisfaction =−0.24, 95% CI: −0.33 to −0.15, P<0.0001). And among female individuals, IBD had impact on most sub-domains of sexual function, except pains.Conclusions: IBD is associated with worse sexual function. It has significant impact on erectile function and satisfaction for male individuals and has impact on most sub-domains of sexual function for female individuals.

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Inflammatory Bowel Disease and the Risk of Erectile Dysfunction

Cited by 2 publications

References 3 publications

Genetic liability to inflammatory bowel disease is causally associated with increased risk of erectile dysfunction: Evidence from a bidirectional Mendelian randomization study

Genetic liability to inflammatory bowel disease is causally associated with increased risk of erectile dysfunction: Evidence from a bidirectional Mendelian randomization study

Inflammatory bowel disease is associated with worse sexual function: a systematic review and meta-analysis

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