Inflammatory bowel disease and thromboembolism

Zezos, Petros; Kouklakis, Georgios; Saibil, Fred

doi:10.3748/wjg.v20.i38.13863

Cited by 133 publications

(117 citation statements)

References 157 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…The risk of thrombotic or thromboembolic complications in the brain is clearly associated with the activity of the disease. During these periods, IBD patients have a higher risk of cerebral thromboembolic complications than the normal population [9,10]. These events are rarely reported during periods of non-activity of the disease [9,10], although some authors have described a higher incidence of thromboembolic events in IBD patients than in healthy controls not only during a relapse of the disease but also during remission periods [15].…”

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

“…Indeed, many studies have reported an association between cardiovascular events and other chronic inlammatory diseases, like rheumatoid arthritis, lupus or psoriasis [21][22][23]. Active IBD is also associated with a higher risk of cardiovascular events (spontaneous or after surgical/invasive procedures), especially in young female patients [9].…”

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

“…This hypercoagulability is associated with an increase of coagulation-associated factors and thrombin levels, as well as ibrin formation; a decrease of natural anticoagulant factors; a decrease in ibrinolytic activity; the presence of endothelial anomalies; and an increase in the count and activity of platelets [9].…”

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

“…During these periods, IBD patients have a higher risk of cerebral thromboembolic complications than the normal population [9,10]. These events are rarely reported during periods of non-activity of the disease [9,10], although some authors have described a higher incidence of thromboembolic events in IBD patients than in healthy controls not only during a relapse of the disease but also during remission periods [15]. Larger cohort and case-control studies are needed to conirm this inding, because if IBD patients sufer more thromboembolic events even during remission periods, anticoagulant therapies might be routinely indicated.…”

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

See 3 more Smart Citations

Neurological Manifestations of Inflammatory Bowel Disease

Plata‐Bello¹,

Acosta-López²

2018

New Concepts in Inflammatory Bowel Disease

View full text Add to dashboard Cite

The inlammatory bowel disease (IBD) is associated with diferent neurological and psychiatric disorders, which are integrated among the extra-intestinal manifestation of this disease. The physiopathology of neurological manifestations of IBD varies among the diferent kind of complications. The origin and the signiicance of these manifestations must be understood by clinicians who manage IBD patients. Some of them are related to therapeutic agents. The present chapter consists of a review of the most prevalent neurological and psychiatric disorders associated with IBD. The physiopathology of those entities will also be discussed, as well as the appropriate management for their prevention and treatment.

show abstract

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

Section: Venous and Arterial Thrombotic And Thromboembolic Manifestatmentioning

confidence: 99%

See 2 more Smart Citations

Neurological Manifestations of Inflammatory Bowel Disease

Plata‐Bello¹,

Acosta-López²

2018

New Concepts in Inflammatory Bowel Disease

View full text Add to dashboard Cite

show abstract

“…The evolution of Crohn's disease might include intestinal and extra-intestinal complications, especially atherothrombotic events (15). Hyperhomocysteinemia has been recognized as one of numerous risk factors for the development of thrombotic conditions in patients with cardiovascular diseases (16). The metabolites of homocysteine and Hcy-related genes may be involved in the pathogenesis of ulcerous colitis (17) and coeliac disease (18).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Subchronic Methionine Overload Administered Alone or Simultaneously with L-cysteine or N-acetyl-L-cysteine on Body Weight, Homocysteine Levels and Biochemical Parameters in the Blood of Male Wistar Rats

Mićović

Stamenković

Nikolić

et al. 2016

Serbian Journal of Experimental and Clinical Research

View full text Add to dashboard Cite

Hyperhomocysteinemia (HHC), both basal and after methionine load, may occur due to genetic disorders or defi ciencies of nutrients that aff ect the remethylation or transsulphuration pathways during methionine metabolism. HHC is involved in the pathogenesis of many illnesses as a SAŽETAK Hiperhomocisteinemija (HHC), kako bazalna tako i nakon ABBREVIATIONSAHDL -direct high-density cholesterol; ALB -albumin; ALP -alkaline phosphatase; ALT -alanine aminotransferase;AMY -amylase; AST -aspartate aminotransferase;bw -body weight BUN -blood urea nitrogen;Ca -calcium; Cl -chloride; CHOL -cholesterol; CREA -creatinine; ECL -electrochemiluminescence immunoassay system; GLUC -glucose; GGT -gamma glutamyl transferase;GSH -glutathione;Hcy -homocysteine; HHC -hyperhomocysteinemia; IBCT -total iron binding capacity;MET -DL-methionine; NAC -N-acetyl-L-cysteine; Na -sodium; RCRP -C-reactive protein; ROS -reactive oxygen species; TBI -total bilirubin; TGL -triglyceride; tHcy -total homocysteine; TP -total protein; URCA -uric acid

show abstract

Exosomes‐transferred LINC00668 Contributes to Thrombosis by Promoting NETs Formation in Inflammatory Bowel Disease

Zhang,

Zheng,

Bai

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Epidemiological studies show an association between inflammatory bowel disease (IBD) and increased risk of thrombosis. However, how IBD influences thrombosis remains unknown. The current study shows that formation of neutrophil extracellular traps (NETs) significantly increased in the dextran sulfate sodium (DSS)‐induced IBD mice, which in turn, contributes to thrombus formation in a NETs‐dependent fashion. Furthermore, the exosomes isolated from the plasma of the IBD mice induce arterial and venous thrombosis in vivo. Importantly, proinflammatory factors‐exposed intestinal epithelial cells (inflamed IECs) promote neutrophils to release NETs through their secreted exosomes. RNA sequencing revealed that LINC00668 is highly enriched in the inflamed IECs‐derived exosomes. Mechanistically, LINC00668 facilitates the translocation of neutrophil elastase (NE) from the cytoplasmic granules to the nucleus via its interaction with NE in a sequence‐specific manner, thereby inducing NETs release and thrombus formation. Importantly, berberine (BBR) suppresses the nuclear translocation of NE and subsequent NETs formation by inhibiting the interaction of LINC00668 with NE, thus exerting its antithrombotic effects. This study provides a novel pathobiological mechanism linking IBD and thrombosis by exosome‐mediated NETs formation. Targeting LINC00668 can serve as a novel molecular treatment strategy to treat IBD‐related thrombosis.

show abstract

Inflammatory bowel disease and thromboembolism

Cited by 133 publications

References 157 publications

Neurological Manifestations of Inflammatory Bowel Disease

Neurological Manifestations of Inflammatory Bowel Disease

The Effects of Subchronic Methionine Overload Administered Alone or Simultaneously with L-cysteine or N-acetyl-L-cysteine on Body Weight, Homocysteine Levels and Biochemical Parameters in the Blood of Male Wistar Rats

Exosomes‐transferred LINC00668 Contributes to Thrombosis by Promoting NETs Formation in Inflammatory Bowel Disease

Contact Info

Product

Resources

About