Inflammatory Bowel Disease in Children: Psychological and Psychiatric Issues

Deshmukh, Parikshit; Kulkarni, Gaurav; Lackamp, Jeanne

doi:10.1007/s11920-010-0111-0

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…Inflammatory bowel disease (IBD) is a broad term used to classify a group of chronic IBD, two of the most common being ulcerative colitis and Crohn's disease (Bousvaros et al, 2006; Deshmukh, Kulkarni, & Lackamp, 2010). Ulcerative colitis inflammation occurs in the large bowel, whereas Crohn's disease can impact any portion of the gastrointestinal tract (Burke, Neigut, Kocoshis, Chandra, & Sauer, 1994).…”

Section: Introductionmentioning

confidence: 99%

An Exploration of Family Problem-Solving and Affective Involvement as Moderators Between Disease Severity and Depressive Symptoms in Adolescents with Inflammatory Bowel Disease

Schuman

Graef

Janicke

et al. 2013

J Clin Psychol Med Settings

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Little is known about how family functioning relates to psychosocial functioning of youth with inflammatory bowel disease (IBD). The study aim was to examine family problem solving and affective involvement as moderators between adolescent disease severity and depressive symptoms. Participants were 122 adolescents with IBD and their parents. Measures included self-reported and parent-reported adolescent depressive symptoms, parent-reported family functioning, and physician-completed measures of disease severity. Disease severity was a significant predictor of adolescent-reported depressive symptoms, but not parent-reported adolescent depressive symptoms. Family affective involvement significantly predicted parent-reported adolescent depressive symptoms, while family problem-solving significantly predicted adolescent self-report of depressive symptoms. Neither affective involvement nor problem-solving served as moderators. Family affective involvement may play an important role in adolescent emotional functioning but may not moderate the effect of disease severity on depressive symptoms. Research should continue to examine effects of family functioning on youth emotional functioning and include a sample with a wider range of disease severity to determine if interventions aimed to enhance family functioning are warranted.

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Section: Introductionmentioning

confidence: 99%

An Exploration of Family Problem-Solving and Affective Involvement as Moderators Between Disease Severity and Depressive Symptoms in Adolescents with Inflammatory Bowel Disease

Schuman

Graef

Janicke

et al. 2013

J Clin Psychol Med Settings

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“…The association of IBD and psychiatric illnesses is well known 37 . Many studies demonstrate the advantages of psychotherapeutic treatment, including faster recovery, improved quality of life, and reduced health care use.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory bowel disease: perspectives from cingulate cortex in the first brain

Vogt

2013

Neurogastroenterology Motil

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The article by Agostini et al. (2013) in this issue of Neurogastroenterology and Motility evaluated patients with Crohn's disease (CD) for volumetric changes throughout the brain. They observed decreased gray matter volumes in dorsolateral prefrontal cortex and anterior midcingulate cortex (aMCC) and disease duration was negatively correlated with volumes in subgenual anterior cingulate (sACC), posterior MCC (pMCC), ventral posterior cingulate (vPCC), and parahippocampal cortices. As all patients were in remission and suffered from ongoing abdominal pain, this study provides a critical link between forebrain changes and abdominal pain experience independent of active disease and drug treatment. The aMCC has a role in feedback-mediated decision making and there are specific cognitive tasks that differentiate aMCC and pMCC that can be used to evaluate defects in CD. The sACC is an important area as it has impaired functions in major depression. As depressive symptoms are a feature in a subset of patients with active inflammatory diseases including IBD, treatment targeting this subregion should prove efficacious. Finally, vPCC has a role in ongoing self-monitoring of the personal relevance of sensory stimuli including visceral signals via sACC. This pathway may be interrupted by vPCC atrophy in CD. Cingulate atrophy in CD leads to targeting chronic pain and psychiatric symptoms via cingulate-mediated therapies. These include psychotherapy, guided imagery and relaxation training, analgesic dosages of morphine or antidepressants, and hypnosis. Thus, a new generation of novel treatments may emerge from drug and non-traditional therapies for CD in this formative area of research.

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“…Epidemiological studies indicate that the incidence of pediatric inflammatory bowel disease (IBD), consisting of Crohn’s disease (CD), ulcerative colitis (UC) and IBD unclassified (IBDU), has been increasing over time[ 1 ]. Elevated levels of depression, anxiety, low self-esteem, disrupted social functioning, family dysfunction, and parental distress are among the most common findings from studies comparing pediatric IBD patients with other chronic disease patients or healthy controls[ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Stressful life events and psychosocial correlates of pediatric inflammatory bowel disease activity

Giannakopoulos¹,

Chouliaras²,

Margoni³

et al. 2016

WJP

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AIMTo investigate the association of psychiatric and psychosocial correlates with inflammatory bowel disease (IBD) activity in children and adolescents.METHODSA total of 85 pediatric IBD patients (in remission or active state of the disease) and their parents completed a series of questionnaires and semi-structured interviews measuring life events, depression, anxiety, family dysfunction, and parent mental health. Differences between the remission and the IBD active group and the association of any significant variable with the disease activity state were examined.RESULTSParents of children being in active state of the disease reported more life events (P = 0.005) and stressful life events (P = 0.048) during the past year and more mental health symptoms (P < 0.001), while the children themselves reported higher levels of anxiety symptoms (P = 0.017) compared to the remission group. In the logistic regression multivariate analysis, the only predictor which had a significant positive effect on the probability of the patients being in active state was parent mental health symptoms (OR = 4.8; 95%CI: 1.2-25.8).CONCLUSIONLife events, child anxiety and parent mental health symptoms may be important correlates of pediatric IBD activity and targets of thorough assessment and treatment.

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Inflammatory Bowel Disease in Children: Psychological and Psychiatric Issues

Cited by 6 publications

References 55 publications

An Exploration of Family Problem-Solving and Affective Involvement as Moderators Between Disease Severity and Depressive Symptoms in Adolescents with Inflammatory Bowel Disease

An Exploration of Family Problem-Solving and Affective Involvement as Moderators Between Disease Severity and Depressive Symptoms in Adolescents with Inflammatory Bowel Disease

Inflammatory bowel disease: perspectives from cingulate cortex in the first brain

Stressful life events and psychosocial correlates of pediatric inflammatory bowel disease activity

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