2016
DOI: 10.1111/1471-0528.13946
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Inflammatory bowel disease in pregnancy: a population‐based study of prevalence and pregnancy outcomes

Abstract: Objective To determine the prevalence of the inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD), in pregnant women and determine pregnancy and fetal/neonatal outcomes.Design Population-based cohort study.Setting New South Wales, Australia, 2001-11.Population A total of 630 742 women who delivered at ≥20 weeks of gestation.Methods Descriptive and multivariate regression analyses of perinatal data linked to hospital admission data. We compared birth outcomes of women with and wit… Show more

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Cited by 61 publications
(81 citation statements)
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“…Chorioamnionitis is often found in PPROM fetal membrane specimens, and the pathways that lead to an accentuated bowel inflammation in Crohn's disease and ulcerative colitis may also contribute to the severity of chorioamnionitis and therefore risk of PPROM. Preterm birth is associated with maternal inflammatory bowel disease but there are no reports that we are aware of that link inflammatory disease in offspring to increased risk of preterm birth and PPROM (Caruso et al 2014;Getahun et al 2014;Palomba et al 2014;Br€ oms et al 2016;Shand et al 2016).…”
Section: Discussionmentioning
confidence: 99%
“…Chorioamnionitis is often found in PPROM fetal membrane specimens, and the pathways that lead to an accentuated bowel inflammation in Crohn's disease and ulcerative colitis may also contribute to the severity of chorioamnionitis and therefore risk of PPROM. Preterm birth is associated with maternal inflammatory bowel disease but there are no reports that we are aware of that link inflammatory disease in offspring to increased risk of preterm birth and PPROM (Caruso et al 2014;Getahun et al 2014;Palomba et al 2014;Br€ oms et al 2016;Shand et al 2016).…”
Section: Discussionmentioning
confidence: 99%
“…A large population‐based study in Australia found rates of pregnancy in women with IBD are higher than previously reported and perinatal outcomes are generally good (Shand et al., ). Similar pregnancy outcomes were achieved for women with IBD compared with non‐IBD controls in a European case‐controlled series (Bortoli et al., ).…”
Section: Introductionmentioning
confidence: 95%
“…However, a recent paper reported women with IBD as more likely to require in vitro fertilisation (IVF), and during pregnancy to have higher rates of hospitalisation, longer length‐of‐stay and more severe maternal morbidity. They are also more likely to have a caesarean birth, higher rates of planned and spontaneous preterm birth and low‐birthweight babies (Shand et al., ). The sample in these studies included IBD patients generally, rather than having a focus on women with ileostomy.…”
Section: Introductionmentioning
confidence: 99%
“…Control of IBD activity at the beginning of, and throughout pregnancy is essential to avoid maternal and fetal complications . Still, the benefit‐to‐treat with TNFα antagonists (anti‐TNFα) for the mother needs to be weighed in light of safety considerations for the fetus.…”
Section: Introductionmentioning
confidence: 99%
“…Control of IBD activity at the beginning of, and throughout pregnancy is essential to avoid maternal and fetal complications. [1][2][3][4] Still, the benefit-to-treat with TNFα antagonists (anti-TNFα) for the mother needs to be weighed in light of safety considerations for the fetus. This is particularly important as infliximab and adalimumab are both very efficiently transported across the placental barrier starting in the second and third trimesters via a FcRN receptor-mediated mechanism.…”
Section: Introductionmentioning
confidence: 99%