Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium

Ahlawat, Shruti; Kumar, Pramod; Mohan, Hari; Goyal, Sandeep; Sharma, Krishna Kant

doi:10.1080/1040841x.2021.1876631

Cited by 79 publications

(53 citation statements)

References 169 publications

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“…Further, the tri-directional relationships between gut microbiome, intestinal epithelium, and mucosal immune system contribute to the pathogenesis of gut-related disorders. 3 Eventually, it leads to changes in the gut microbiome that comprises bacteria, fungi, protozoa, and viruses present as commensals, symbionts, and pathobionts. Microbiomes form dynamic and interactive micro-ecosystems that integrate with macro-ecosystems, including eukaryotic hosts.…”

Section: Introductionmentioning

confidence: 99%

Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile

et al. 2021

Self Cite

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“…The intestinal flora is currently considered to be a complex ecosystem, which is (Ahlawat et al 2021b ) composed of 500–1000 different species, accounting for 10 14 bacterial cells, which is 10 times more than that of the total number of human cells (Domingo and Sanchez 2018 ). The genome of all intestinal microorganisms is known as “microbiome”, which is more than 100-times larger than the human nuclear genome (Huang et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

A case–control study on the association of intestinal flora with ulcerative colitis

et al. 2021

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The association between intestinal flora and ulcerative colitis (UC) was studied in order to provide a basis and method for clinical treatment. Fresh fecal samples were collected from 30 active UC patients and 10 healthy controls. The intestinal flora DNA from each sample was extracted and 16S rRNA gene sequencing was carried out using HiSeq platform to identify the intestinal flora in fecal samples. The richness and diversity of intestinal flora in UC patients were significantly lower than those in healthy control group (P < 0.05). Significant differences were observed between the intestinal flora-species of UC patients and healthy controls. Synergistetes (P < 0.01) and Firmicutes (P < 0.05), along with probiotics Veillonella (P < 0.01), Ruminococcus and Coprococcus (P < 0.05) in the UC patients were lower than that in the healthy controls significantly. Furthermore, compared with the control group, Tenericutes (P < 0.01) and intestinal pathogenic bacteria, including Bacteroides (P < 0.01), Escherichia and Sutterella (P < 0.05) were significantly increased. The incidence of UC is significantly associated with the changes in intestinal flora. Changes in intestinal flora may lead to a decrease in the diversity of intestinal flora or to the enrichment of a particular intestinal flora.

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“…Gut microbiota is a complex and dynamic ecosystem that controls the permeability of the gastrointestinal mucosa and the host immune system, which is closely associated with UC (Ahlawat et al., 2021 ). However, the present ODDSs for the treatment of UC rarely consider the effects of intestinal homeostasis and gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice

Jin

et al. 2021

Drug Delivery

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Oral route colon-targeted drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC). However, CDDSs are challenging owing to the physiological and anatomical barriers associated with the gastrointestinal tract (GIT). In this study, we developed an effective enzyme-triggered controlled release system using curcumin–cyclodextrin (CD–Cur) inclusion complex as core and low molecular weight chitosan and unsaturated alginate resulting nanoparticles (CANPs) as shell. The formed CD–Cur–CANPs showed a narrow particle-size distribution and a compact structure. In vitro drug release determination indicated that CD–Cur–CANPs showed pH-sensitive and α-amylase-responsive release characteristics. Furthermore, in vivo experiments demonstrated that oral administration of CD–Cur–CANPs had an efficient therapeutic efficacy, strong colonic biodistribution and accumulation, rapid macrophage uptake, promoted colonic epithelial barrier integrity and modulated production of inflammatory cytokines, reshaped the gut microbiota in mice with dextran sodium sulfate (DSS)-induced colitis. Taken together, our synthetic CD–Cur–CANPs are a promising synergistic colon-targeted approach for UC treatment.

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Inflammatory bowel disease: tri-directional relationship between microbiota, immune system and intestinal epithelium

Cited by 79 publications

References 169 publications

Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile

Pathobionts: mechanisms of survival, expansion, and interaction with host with a focus on Clostridioides difficile

A case–control study on the association of intestinal flora with ulcerative colitis

An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice

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