Inflammatory Bowel Diseases with Onset in Childhood: Clinical Features, Morbidity, and Mortality in a Regional Cohort

Langholz, Ebbe; Munkholm, Pia; Krasilnikoff, P. A.; Binder, Vibeke

doi:10.3109/00365529709000184

Cited by 234 publications

(174 citation statements)

References 33 publications

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“…The median PCDAI was 25 and median PUCAI was 35, as in this report. These results are in concordance with earlier findings, where more than 70% of children had moderate to severe disease at diagnosis based on clinical symptoms (15) or physician global assessment (PGA) (16). In previous studies, Dubner et al evaluated bone mineral density and structure in a smaller cohort of CD patients, and described that median PCDAI decreased from 36 (at diagnosis) to 5 (12 months after diagnosis) (17), respectively.…”

Section: Discussionsupporting

confidence: 87%

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Müller

Lakatos

Kovács

et al. 2016

J. pediatr. gastroenterol. nutr.

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Section: Discussionsupporting

confidence: 87%

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Müller

Lakatos

Kovács

et al. 2016

J. pediatr. gastroenterol. nutr.

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“…3 The higher incidence among males is similar to that of previous paediatric, 7 10 but not that of adult studies. 14 In contrast with most previous reports 4 15 -except for two recent studies 10 16 -colonic CD or colon combined with upper gastrointestinal tract involvement was common (80%) whereas exclusive small bowel CD was not.…”

Section: Discussionmentioning

confidence: 64%

Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001

Hildebrand

2003

Gut

196

135

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Background: An increased incidence of paediatric Crohn's disease was reported recently by our group. Aims: To assess the incidence and characteristics of inflammatory bowel disease (IBD) in northern Stockholm between 1990 and 2001. Methods: All records of individuals 0-15 years of age with suspected IBD in the population based catchment area of 180 000 individuals were scrutinised using defined diagnostic criteria. Patient files were searched for relatives with IBD, and for concomitant autoimmune diseases. Results: A total of 152 children were diagnosed with IBD, corresponding to an overall incidence (per 100 000) of IBD of 7.4. The incidence of Crohn's disease (CD) was 4.9, ulcerative colitis (UC) 2.2, and indeterminate colitis 0.2. Between 1990 and 2001, there was a marked increase in the incidence of CD while the incidence of UC was almost unchanged, leading to a net increase in the overall occurrence of IBD. There was a male dominance of CD. Fourteen per cent and 11% of patients with CD and UC, respectively, had a first or second degree relative with IBD. Eighteen per cent and 10% of patients with CD and UC, respectively, had a concomitant autoimmune disease. Ten patients with CD (10%) underwent surgery. Conclusions: The incidence of CD has increased in northern Stockholm. The current incidence is higher than that reported from other areas. Our results suggest a shift in presentation and diagnosis from UC towards CD, but also a net increase in IBD. Concomitant autoimmune disorders and family history are common in paediatric IBD.

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“…Very few children demonstrate symptoms before 5 years of age, when diagnosis of ASD is usually made. 103,104 For children with ASD and gastrointestinal symptoms evaluated by a gastroenterologist, the onset of loose stools was variable and, when remembered by parents, it was usually during the second year of life. 105,106 In a French population of 325 000 schoolaged children, no children with autism (n ϭ 174; prevalence: 5.3 per 10 000) were diagnosed with IBD.…”

Section: Discussionmentioning

confidence: 99%

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

Halsey¹,

Hyman²

2001

Pediatrics

138

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ABSTRACT. Background. Parents and physicians are understandably concerned about the causes and treatment of autism, a devastating disease that affects the entire family. Although much has been learned about autism, there are many gaps in our knowledge about what causes the disorder and how it can be prevented. Autistic symptoms occur along a spectrum, often referred to as autistic spectrum disorder (ASD). Concern has been raised about a possible association between measlesmumps-rubella (MMR) vaccine and inflammatory bowel disease (IBD) and ASD, especially autism with regression. Also, increased requests for educational services related to ASD have raised concerns about possible increases in the incidence of ASD.Methods. On June 12-13, 2000, the American Academy of Pediatrics (AAP) convened a conference titled "New Challenges in Childhood Immunizations" in Oak Brook, Illinois. At this conference, parents, practitioners, and scientists presented information and research on MMR vaccine and ASD. Attendees included representatives from select AAP committees and sections as well as federal and other organizations that address related issues. The multidisciplinary panel of experts reviewed data on what is known about the pathogenesis, epidemiology, and genetics of ASD and the available data on hypothesized associations with IBD, measles, and MMR vaccine. Supplemental information was requested from authors who have proposed the hypotheses and other experts in relevant areas.Results. Autism is a complex disorder of uncertain and probably multiple etiologies. Genetic predisposition to ASD may involve as many as 10 genes. Many experts believe that the abnormal brain development in autism occurs before 30 weeks' gestation in most instances. In utero rubella is a known cause of autism. Animal model data support the biologic plausibility that exposure to yet unrecognized infectious or other environmental agents could cause ASD.Several factors may contribute to apparent increases in incidence of ASD in recent years. Most data indicate increased recognition and reporting as primary factors, but the epidemiologic data are insufficient to determine if there has been a true increase in the incidence of ASD. Increased reporting of ASD in recent years has occurred long after the introduction of MMR vaccine in the United States in 1971 and widespread use of this vaccine in the 1970s for routine immunization of children at 12 to 15 months of age. Appropriate detailed studies are needed to define the true incidence and prevalence of ASD. Epidemiologic studies in Europe indicate no association between MMR vaccine and ASD.Some children with ASD have gastrointestinal symptoms, but an increased rate of any specific gastrointestinal disorder in children with ASD has not been established. Studies to detect evidence of measles virus in intestinal tissue specimens from patients with IBD or autism with gastrointestinal symptoms have not used uniform techniques. Several laboratories have found no evidence of measles viruses in tissue specimens f...

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Inflammatory Bowel Diseases with Onset in Childhood: Clinical Features, Morbidity, and Mortality in a Regional Cohort

Abstract: The incidence of IBD is low in childhood. At diagnosis children with UC have more widespread disease than adults. Childhood-onset CD does not differ in clinical presentation, disease course, or prognosis from adult-onset CD. However, growth retardation is a problem among male CD patients.

Cited by 234 publications

References 33 publications

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Baseline Characteristics and Disease Phenotype in Inflammatory Bowel Disease

Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001

Measles-Mumps-Rubella Vaccine and Autistic Spectrum Disorder: Report From the New Challenges in Childhood Immunizations Conference Convened in Oak Brook, Illinois, June 12–13, 2000

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