Inflammatory breast cancer: MR imaging findings

Carbognin, Giovanni; Calciolari, C.; Girardi, V.; Camera, Lucia; Pollini, Giovanni Paolo; Mucelli, Roberto Pozzi

doi:10.1007/s11547-009-0475-6

Cited by 14 publications

(7 citation statements)

References 16 publications

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“…MRI is highly sensitive for depicting primary breast parenchymal lesions and global skin abnormalities that may help diagnose inflammatory breast cancer. Lesions that were either heterogeneous or inhomogeneous, consisting of a reticular or dendritic internal enhancement with a washout or plateau kinetic curve, were commonly noted [26][27][28][29]. This is different from our findings in non-puerperal mastitis.…”

Section: Discussioncontrasting

confidence: 96%

“…These aforementioned manifestations in non-puerperal mastitis are slight or rare [8]. Inflammatory breast cancer usually affects females of approximately 50 years old [26,27], but non-puerperal mastitis is more common in females under 40 [5,10,11,13]. MRI is highly sensitive for depicting primary breast parenchymal lesions and global skin abnormalities that may help diagnose inflammatory breast cancer.…”

Section: Discussionmentioning

confidence: 99%

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Radiological and clinical features of adult non-puerperal mastitis

Tan¹,

Li²,

Peng³

et al. 2013

BJR

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Objective: To describe the radiological and clinical features of adult non-puerperal mastitis and to determine the most accurate method of preventing unnecessary surgical procedures.Methods: Clinical and imaging findings were retrospectively reviewed in 51 females with non-puerperal mastitis, which was confirmed by biopsy/surgical pathology. All 51 patients had pre-operative MRI; 45 patients also had sonograms and 25 also had mammograms, pre-operatively.Results: Of the 51 cases with non-puerperal mastitis, 94.1% (48/51) were confirmed as having acute or chronic inflammation, and the other 3 had plasma cell mastitis; areola papillaris inflammation was found in 39.2% (20/51) of the cases. Overall, 6 of the 25 cases that were examined with mammography and 2 of the 45 cases that were examined with sonography appeared normal, but all 51 lesions were positively identified on MRI. Asymmetrical density (12/25) on mammograms and solitary or separated/ contiguous, clustered, hypoechoic mass-like lesions (31/45) on ultrasound were the most common signs of non-puerperal mastitis. On enhanced MRI, 90.2% (46/51) of patients showed non-mass-like enhanced lesions. Multiple regional enhancements in the pattern of distribution (32/46) and separated or contiguous, clustered, rim-like enhancements in the pattern of internal enhancement (29/46) were the most common manifestations in nonmass-like enhanced lesions. Of the 51 patients, mastitis Type 1 and Type 2 in the time-signal intensity curve were detected in 47.1% and 51.0% of the patients, respectively. The breast imaging reporting and data system categories with the highest number of patients were Category 0 (9/ 25) on mammography, Category 4a on sonography (18/45) and Category 4a on MRI (29/51). Conclusion:The findings from mammography and ultrasound are non-specific; therefore, using MR can be helpful in the diagnosis, especially in the presence of non-mass-like enhancements that are multiple, regional, separated, or contiguous, clustered and rim-like.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Radiological and clinical features of adult non-puerperal mastitis

Tan¹,

Li²,

Peng³

et al. 2013

BJR

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“…In 2010 Carbognin et al reported features of inflammatory breast cancer on MRI. They reported a hypertrophic IMA in 21 % of the patients [17]. In healthy persons the breast is mainly perfused by the IMA [11].…”

Section: Discussion and Further Perspectivesmentioning

confidence: 99%

Bilateral analysis of the cross-sectional area of the internal mammary arteries and veins in patients with and without breast cancer on breast magnetic resonance imaging

et al. 2013

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ObjectiveTo analyse bilateral differences in the cross-sectional area of the internal mammary artery (IMA) and vein (IMV) in breast cancer patients compared to healthy controls.Materials and methodsOn 135 breast MRIs the cross-sectional areas of the IMA and IMV were measured on the left and right side in the second and third intercostal space (ICS) by two independent readers. Differences were analysed using a linear mixed model.ResultsIn the healthy control group (n = 91) no significant differences between the cross-sectional areas of the IMA and IMV were observed. Both readers reported a mean adjusted difference of 0.12 mm2 (p = 0.298) and 0.21 mm2 (p = 0.058) for the IMA in the second ICS. In the malignancy group (n = 44) the cross-sectional area was significantly larger on the malignancy side compared to the contralateral side. The largest difference in the IMA was measured in the second ICS with a mean adjusted difference for reader 1 of 1.37 mm2 (p < 0.001) and for reader 2 of 0.81 mm2 (p = 0.003).ConclusionsThe vascular cross-sectional area of internal mammary vessels was significantly different on the side with breast cancer compared to the contralateral side. This difference was not observed in healthy controls.Main messagesMRI has become an important imaging modality in the diagnostic workup of breast cancer.In healthy persons no significant difference in the size of the left and right IMA is observed.A significant enlargement of the IMA on the malignant side occurs in most patients.

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“…All authors contributed to the manuscript revision and approved the submitted version. [19] 664 (17) 2248 561093 (27) 56 [19] 561 (18) 1729 56792 (26) 56 [17] 1112 (18) 358 59140 (23) 56 [19] 157 (18) 467 55229 (27) .011 ¶ (31) 512 (13) 1872 47387 (10) 946 (31) 345 (11) 1473 48318 (10) 200 (33) 83 14282 4645 7285 (33) 91 (11) 395 4682 (10) .14 † 1181 2938 12056 51175 (4) 438 14822 (27) 27 11642 53153 (5) 106 (17) 160 263 (<1)…”

Section: Discussionmentioning

confidence: 99%

“…[17] IBC is characterized by either diffused or localized radiographic density. [18] In most cases, the sign and symptoms of IBC will appear within a 6-month period. [19] The expression of different cell growth and apoptosis related markers on the surface of IBC cells play an important role in disease prognosis and management.…”

Section: Pathophysiology and Classification Of Ibcmentioning

confidence: 99%

Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics

Biswas

Jindal

Fitzgerald

et al. 2018

Preprint

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The aim of this study was to examine pathologic complete response (pCR) and overall survival (OS) of patients diagnosed with non-metastatic inflammatory breast cancer (IBC). A total of N=8,550 cases undergoing surgery were identified between 2004-2013, using the National Cancer Database (NCDB). Patients were grouped into 4 biologic subtypes (HR+/HER2-, HR+/HER2+, HR-/HER2+, HR-/HER2-). The median age at diagnosis was 56 years. On average, women were followed for 3.7 years [interquartile range=3.0]. The majority were white (80%), had private health insurance (50%), and presented with poorly differentiated tumors (57%). Approximately 46% of the cancers were >5cm. Most patients underwent mastectomy (94%) and received radiotherapy (71%). Differences by biologic subtypes were observed for grade, lymph node invasion, race, and tumor size (p<.0001). Compared with non-pCR (54%), patients experiencing pCR had superior 5-year survival (77%) (p<.0001). Survival was poor for triple-negative (TN) tumors (37%) vs. other biologic subtypes (60%) (p<.0001). On multivariable analysis, TN-IBC, positive margins, and not receiving either chemotherapy, hormonal therapy or radiotherapy were independently associated with poor 5-year survival (p<.0001). In this large multicentric analysis of IBC, categorized by biologic subtypes, we observed significant differential tumor, patient and treatment characteristics, and OS.

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Inflammatory breast cancer: MR imaging findings

Cited by 14 publications

References 16 publications

Radiological and clinical features of adult non-puerperal mastitis

Radiological and clinical features of adult non-puerperal mastitis

Bilateral analysis of the cross-sectional area of the internal mammary arteries and veins in patients with and without breast cancer on breast magnetic resonance imaging

Pathologic Complete Response (pCR) and Survival of Women with Inflammatory Breast Cancer (IBC): An Analysis Based on Biologic Subtypes and Demographic Characteristics

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